Prosomatostatin processing in anglerfish brain, gut and pancreas.

abstract：:Restenosis after angioplasty is thought to be caused by proliferation and migration of vascular smooth muscle cells (VSMCs), and it is a most serious problem in medical treatment. A low dose (50 ng/ml) of manumycin A, an inhibitor of p21(ras) (ras) farnesylation, significantly inhibited proliferation of rat VSMCs stim...

journal_title：Biochemical and biophysical research communications

authors： Kouchi H,Nakamura K,Fushimi K,Sakaguchi M,Miyazaki M,Ohe T,Namba M

更新日期：1999-11-02 00:00:00

abstract：:ASC2 structure has been well defined by 1141 NOE experimental restraints. The model consists of five alpha helices. alpha-Helices are connected by short random structure loops. The sole exception is the loop connecting helices 2 and 3, which has a 20-residue length. Folding generally agrees with the folding of recentl...

journal_title：Biochemical and biophysical research communications

authors： Espejo F,Patarroyo ME

更新日期：2006-02-17 00:00:00

abstract：:Insulin in rat adipose tissue acts to increase the phosphorylation about 2.5-fold of a low molecular weight protein in the cytosol designated phosphoprotein m. Isoproterenol had no effect on the phosphorylation of phosphoprotein m. Some of the properties of phosphoprotein m are: soluble in 1% trichloro acetic acid, he...

journal_title：Biochemical and biophysical research communications

authors： Ramakrishna S,Benjamin WB

更新日期：1983-12-28 00:00:00

abstract：:Complete nucleotide sequence of the genes for subunits of the H+ ATPase of E.coli has been determined and several hybrid plasmids carrying various portions of these genes have been constructed. Genetic complementation and recombination tests of about forty mutants of E.coli defective in the ATPase were performed using...

journal_title：Biochemical and biophysical research communications

authors： Noumi T,Kanazawa H

更新日期：1983-02-28 00:00:00

abstract：:One of the major roles of brain-derived neurotrophic factor (BDNF) is to promote the differentiation and support the survival of neurons in the central nervous system. The objective of the present study was to evaluate the effect of BDNF on the fate of adult rat hippocampus-derived neural stem cells (AHPCs) transplant...

journal_title：Biochemical and biophysical research communications

authors： Suzuki T,Ooto S,Akagi T,Amemiya K,Igarashi R,Mizushima Y,Takahashi M

更新日期：2003-10-03 00:00:00

abstract：:Human myogenic cells have limited ability to proliferate in culture. Although forced expression of telomerase can immortalize some cell types, telomerase alone delays senescence of human primary cultured myogenic cells, but fails to immortalize them. In contrast, constitutive expression of both telomerase and the E7 g...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto N,Kiyono T,Wada MR,Shimizu S,Yasumoto S,Inagawa M

更新日期：2006-10-06 00:00:00

abstract：:Ubiquitin (Ub) carboxyl-terminal hydrolase L1 (UCH-L1) has dual functions, such as hydrolase activity on the chemical bonds formed by the C-terminal Gly of Ub and dimerization-dependent ubiquitin ligase activity. Accumulating evidence suggests that dual activities of UCH-L1 were intimately associated with Parkinson's ...

journal_title：Biochemical and biophysical research communications

authors： Park DW,Nam MK,Rhim H

更新日期：2011-11-11 00:00:00

abstract：:5-Lipoxygenase (5LO) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. LTs function in normal host defense, and have pathophysiological roles in chronic inflammatory diseases as asthma and atherosclerosis. Also, possible effects of 5LO product...

journal_title：Biochemical and biophysical research communications

authors： Rådmark O,Samuelsson B

更新日期：2010-05-21 00:00:00

abstract：:A new and simple method for the detection of antigenic proteins blotted onto nitrocellulose was developed. After transfer of spinach stromal proteins and purified phosphoribulokinase immunolabeling was performed with phosphoribulokinase antiserum, followed by a) Protein A-labeled colloidal gold particles, and b) by ho...

journal_title：Biochemical and biophysical research communications

authors： Surek B,Latzko E

更新日期：1984-05-31 00:00:00

abstract：:N1999A2 (NA2) is a new non-protein antitumor antibiotic that contains a stable 9-membered ring enediyne chromophore similar to a neocarzinostatin chromophore (NCS-chr). We have compared DNA cleavage reactions between NA2 and NCS-chr, and also clarified some characteristics of DNA strand scission by NA2. It was found t...

journal_title：Biochemical and biophysical research communications

authors： Miyagawa N,Sasaki D,Matsuoka M,Imanishi M,Ando T,Sugiura Y

更新日期：2003-06-20 00:00:00

abstract：:Human monomorphic and polymorphic arylamine acetyltransferases (EC 2.3.1.5) were expressed in monkey kidney COS-1 cells and used to study the N- and O-acetylation of a number of carcinogenic amines and their N-hydroxy metabolites. The monomorphic enzyme N-acetylated the aromatic amines, 2-aminofluorene and 4-aminobiph...

journal_title：Biochemical and biophysical research communications

authors： Minchin RF,Reeves PT,Teitel CH,McManus ME,Mojarrabi B,Ilett KF,Kadlubar FF

更新日期：1992-06-30 00:00:00

abstract：:The mouse gene encoding the mu opioid receptor, Oprm, undergoes extensive alternatively splicing, with 14 variants having been identified. However, only one variant of human mu opioid receptor gene (Oprm), MOR-1A, has been described. We now report two novel splice variants of the human Oprm gene, hMOR-1O and hMOR-1X. ...

journal_title：Biochemical and biophysical research communications

authors： Pan YX,Xu J,Mahurter L,Xu M,Gilbert AK,Pasternak GW

更新日期：2003-02-21 00:00:00

abstract：:The basic helix-loop-helix (bHLH) transcription factor mammalian achaete-scute homolog-1 (MASH-1 in mouse and HASH-1 in human) is essential for proper development of olfactory and most peripheral autonomic neurons, and for the formation of distinct neuronal circuits within the central nervous system. We have previousl...

journal_title：Biochemical and biophysical research communications

authors： Persson P,Jögi A,Grynfeld A,Påhlman S,Axelson H

更新日期：2000-07-21 00:00:00

abstract：:Glycyrrhetinic acid (GA), a triterpene saponins, has been widely proven to have multiple medicinal properties. Our study aimed to figure out the protective effect of GA on acute lung injury (ALI) and the underlying mechanism. The LPS-induced ALI model mice were intratracheally administrated with 10 mg/kg LPS. Pretreat...

journal_title：Biochemical and biophysical research communications

authors： Wang K,Zhang Y,Cao Y,Shi Z,Lin Y,Chen Y,Zhao H,Liu X

更新日期：2020-11-19 00:00:00

abstract：:Increasing evidence indicates that dysregulation of microRNAs (miRNAs) contributes to tumorigenesis. MicroRNA-340 (miR-340) is downregulated in several types of cancer. However, the functional mechanism of miR-340 in hepatocellular carcinoma (HCC) remains unclear. Here, we showed that miR-340 was significantly downreg...

journal_title：Biochemical and biophysical research communications

authors： Yuan J,Ji H,Xiao F,Lin Z,Zhao X,Wang Z,Zhao J,Lu J

更新日期：2017-01-29 00:00:00

abstract：:Catabolite inactivation of fructose 1,6-bisphosphatase and cytoplasmic malate dehydrogenase was studied using the protease-deficient and vacuole-defective yeast strain pep4-3. The catabolite inactivation of fructose 1,6-bisphosphatase in pep4-3 was found to have a normal first inactivation step but with a defective se...

journal_title：Biochemical and biophysical research communications

authors： Funaguma T,Toyoda Y,Sy J

更新日期：1985-07-16 00:00:00

abstract：:Infection and/or drug-mediated acute liver injury, the leading cause of lethal liver failure, is a critical health problem worldwide and lacks effective treatment. Here, we used Lipopolysaccharides (LPS)/D-galactosamine (D-gal)-treated primary hepatocytes to screen a natural library that contains 1130 chemicals. Baica...

journal_title：Biochemical and biophysical research communications

authors： Xiao T,Cui Y,Ji H,Yan L,Pei D,Qu S

更新日期：2021-01-01 00:00:00

abstract：:The fragile X syndrome, one of the most common forms of inherited mental retardation, is caused by an expansion of a polymorphic CGG repeat upstream the coding region of the FMR1 gene. These expansions are associated with hypermethylation of the FMR1 gene, which results in the absence of the gene product, the FMR1 pro...

journal_title：Biochemical and biophysical research communications

authors： Willemsen R,Bontekoe C,Tamanini F,Galjaard H,Hoogeveen A,Oostra B

更新日期：1996-08-05 00:00:00

abstract：:Dietary supplementation with coenzyme Q (CoQ) has been proposed to have anti-atherogenic effects by virtue of its antioxidant capacity. To investigate this question, the leukocyte status of 5 males and 5 females (52-68 years) was evaluated before and after supplementation with 200mg CoQ/day for 5 and 10 weeks. CoQ was...

journal_title：Biochemical and biophysical research communications

authors： Turunen M,Wehlin L,Sjöberg M,Lundahl J,Dallner G,Brismar K,Sindelar PJ

更新日期：2002-08-16 00:00:00

abstract：:Spontaneous Arg- mutants arose at high frequencies in Streptomyces lividans. Exposure to ethidium bromide increased the frequency of arg instability. In Pro+ strains the induced arg mutants were mainly argG, but in the proB mutants, a new mutation, argJ, prevailed which lacked ornithine acetyltransferase activity and ...

journal_title：Biochemical and biophysical research communications

authors： Chou CF,Chen CW

更新日期：1992-12-15 00:00:00

abstract：:Human serum albumin (HSA) patterns have been successfully fabricated for the deposition of lipid bilayer, 1,2-dimyristoyl-sglycerophosphate (DMPA), by making use of the micro-contact printing (microCP) technique and liposome fusion. Confocal laser scanning microscopy (CLSM) results indicate that lipid bilayer has been...

journal_title：Biochemical and biophysical research communications

authors： Zhang X,He Q,Cui Y,Duan L,Li J

更新日期：2006-10-27 00:00:00

abstract：:These studies sought to test the hypothesis that magnesium inhibits extracellular calcium entry, thereby inhibiting intracellular calcium release and cytosolic calcium oscillations in myometrial smooth muscle. In vitro contraction studies were performed using oxytocin and other uterotonic agonists with and without the...

journal_title：Biochemical and biophysical research communications

authors： Phillippe M

更新日期：1998-11-18 00:00:00

abstract：:Full-length human p53 protein was examined using tryptophan fluorescence and circular dichroism spectroscopy (CD) to monitor unfolding. No significant alteration in tryptophan fluorescence for the tetrameric protein was detectable over a wide range of either urea or guanidine hydrochloride concentrations, in contrast ...

journal_title：Biochemical and biophysical research communications

authors： Nichols NM,Matthews KS

更新日期：2001-10-19 00:00:00

abstract：:Recent evidence has revealed a novel signaling mechanism through which brown adipose tissue (BAT)-derived exosomal microRNAs (miRNAs) influence hepatic gene expression. Here, we uncover neuronal control of these miRNAs and identify exosomal miR-132-3p as a regulator of hepatic lipogenesis under cold stress conditions....

journal_title：Biochemical and biophysical research communications

authors： Kariba Y,Yoshizawa T,Sato Y,Tsuyama T,Araki E,Yamagata K

更新日期：2020-09-24 00:00:00

abstract：:The crude extracts from Sphingomonas paucimobilus containing 2-hydroxy fatty acid-rich sphingolipids were found to oxidize [1-14C]-myristate to 2-hydroxymyristate in the presence of NADH. The myristate-oxidation activity was partially purified about 290-fold from the cell-free extracts by ammonium sulfate fractionatio...

journal_title：Biochemical and biophysical research communications

authors： Matsunaga I,Kusunose E,Yano I,Ichihara K

更新日期：1994-06-30 00:00:00

abstract：:Nuclear-Factor-kappaB (NF-kappaBeta can counteract transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in malignant hepatocytes through up-regulation of its downstream genes, such as X-linked inhibitor of apoptosis protein (XIAP). Reports have demonstrated that TGF-beta1 can induce oxidative stress, and c-J...

journal_title：Biochemical and biophysical research communications

authors： Wang F,Kaur S,Cavin LG,Arsura M

更新日期：2008-12-26 00:00:00

abstract：:Here, we report on the first attempt to bioengineer tooth using a spontaneously immortalized mesenchymal cell line. To assess the odontogenic potential of this cell line, odontoblast-lineage cells (OLC) were re-associated with competent dental epithelium isolated from E14.5 mice. A novel three-dimensional organ germ c...

journal_title：Biochemical and biophysical research communications

authors： Arany S,Kawagoe M,Sugiyama T

更新日期：2009-03-27 00:00:00

abstract：:Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra. Prevailing evidence suggests that abnormal autophagy and mitochondrial dysfunction participate in the process of PD. However, many damages of neuronal functions are regulated b...

journal_title：Biochemical and biophysical research communications

authors： Zhao M,Chen J,Mao K,She H,Ren Y,Gui C,Wu X,Zou F,Li W

更新日期：2019-02-05 00:00:00

abstract：:In the case of a new viral disease outbreak, an immediate development of virus detection kits and vaccines is required. For COVID-19, we established a rapid production procedure for SARS-CoV-2 spike protein (S protein) by using the baculovirus-silkworm expression system. The baculovirus vector-derived S proteins were ...

journal_title：Biochemical and biophysical research communications

authors： Fujita R,Hino M,Ebihara T,Nagasato T,Masuda A,Lee JM,Fujii T,Mon H,Kakino K,Nagai R,Tanaka M,Tonooka Y,Moriyama T,Kusakabe T

更新日期：2020-08-20 00:00:00

abstract：:A cDNA coding for rat IL-5 was obtained by RT-PCR from total spleen RNA. With the exception of a single a.a. replacement at position 85 (L-P), it is identical to the published sequence obtained by retroviral gene transfer. This cDNA was used to express biologically active recombinant IL-5 in E. coli and in insect cell...

journal_title：Biochemical and biophysical research communications

authors： Pierrot C,Cocude C,Cêtre C,Godin C,Lafitte S,Capron M,Khalife J

更新日期：1998-12-30 00:00:00