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Application of spontaneously immortalized odontoblast cells in tooth regeneration.

Abstract：

:Here, we report on the first attempt to bioengineer tooth using a spontaneously immortalized mesenchymal cell line. To assess the odontogenic potential of this cell line, odontoblast-lineage cells (OLC) were re-associated with competent dental epithelium isolated from E14.5 mice. A novel three-dimensional organ germ culture method was applied to nurture the constructs in vitro. Additionally, recombinants were transplanted under the kidney capsule in host animals for 2 weeks. Transplants developed into tooth tissues in one-third of the cases. OLC-derived GFP-positive cells could be identified in mineralizing tooth germs by immunohistochemistry. OLCs were capable of intercellular and cell-matrix communication, thus they eventually differentiated into functional odontoblasts. In summary, we managed to utilize OLCs for dental mesenchyme substitution in tooth regeneration experiments. Therefore, our spontaneously transformed cell line proved its potential for future complex, tooth developmental and bioengineering studies.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Arany S,Kawagoe M,Sugiyama T

doi

10.1016/j.bbrc.2009.02.025

subject

Has Abstract

pub_date

2009-03-27 00:00:00

pages

84-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)00274-5

journal_volume

381

pub_type

杂志文章

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