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The importance of adenosine deaminase for lymphocyte development and function.

Abstract：

:Deficiency in the enzyme adenosine deaminase (ADA) in humans manifests primarily as severe lymphopenia and immunodeficiency, resulting in death by 6 months of age, if untreated. In this review, we discuss phenotypical, biochemical, and metabolic hallmarks of the disease, and describe a mouse model in which levels of ADA can be biochemically and genetically manipulated. This model provides exciting possibilities for uncovering the mechanisms by which this purine catabolic enzyme affects lymphopoiesis.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Aldrich MB,Blackburn MR,Kellems RE

doi

10.1006/bbrc.2000.2773

subject

Has Abstract

pub_date

2000-06-07 00:00:00

pages

311-5

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(00)92773-6

journal_volume

272

pub_type

杂志文章,评审

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