Modification of cell surfaces by enzymatic introduction of special sialic acid analogues.

abstract：:We previously reported not only that chicken HIRA, a homolog of Saccharomyces cerevisiae transcriptional corepressors Hir1p and Hir2p, possesses seven WD dipeptide motifs and a LXXLL motif in its N-terminal half and C-terminal half, respectively, but also that the N-terminal and C-terminal halves, respectively, bind t...

journal_title：Biochemical and biophysical research communications

authors： Ahmad A,Takami Y,Nakayama T

更新日期：2003-12-26 00:00:00

abstract：:TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) administered to young male guinea pigs at a dose of 1 microgram/kg (single intraperitoneal injection) caused a large reduction in adipose tissue lipoprotein lipase (LPL) activity. This effect occurred rapidly; a 70% decrease was noticed after 24 hour and 80% of LPL activity w...

journal_title：Biochemical and biophysical research communications

authors： Brewster DW,Matsumura F

更新日期：1984-07-31 00:00:00

abstract：:The transcription of human nm23 genes (nm23-H1, nm23-H2) is involved in suppression of tumor metastasis or tumor progression. Therefore the characterization of transcriptional regulatory mechanisms for both nm23 genes is very important. In this study we have isolated and analyzed the 5'-flanking region of the human nm...

journal_title：Biochemical and biophysical research communications

authors： Seifert M,Seib T,Engel M,Dooley S,Welter C

更新日期：1995-10-24 00:00:00

abstract：:Cholecystokinin (CCK) dose-dependently stimulates enzyme secretion or loss of cell integrity in the exocrine pancreas. Signaling mechanims include tyrosine phosphorylation of p125(FAK) and paxillin. Here, we examine their potential function. Maximum phosphorylation of both proteins was observed after stimulation of fr...

journal_title：Biochemical and biophysical research communications

authors： Leser J,Lührs H,Beil MF,Adler G,Lutz MP

更新日期：1999-01-19 00:00:00

abstract：:The mechanism(s) involved in the generation of free radicals in human leukocytes by phorbol myristate acetate (PMA), formyl-methionyl-leucyl-phenylalanine (FMP), lipopolysaccharide (LPS), arachidonic acid (AA), and recombinant-tumor necrosis factor-1-alpha (r-TNF-1 alpha) was investigated. Calmodulin antagonists, chlo...

journal_title：Biochemical and biophysical research communications

authors： Das UN,Padma M,Sagar PS,Ramesh G,Koratkar R

更新日期：1990-03-30 00:00:00

abstract：:Estrogen receptor alpha (ERα) is a nuclear receptor that regulates a range of physiological processes in response to estrogens. In order to study its biological role, we generated a floxed ERα mouse line that can be used to knock out ERα in selected tissues by using the Cre/LoxP system. In this study, we established a...

journal_title：Biochemical and biophysical research communications

authors： Antonson P,Omoto Y,Humire P,Gustafsson JÅ

更新日期：2012-08-10 00:00:00

abstract：:A two-component regulatory system involving StyS and StyR is involved in the regulation of indigo synthesis in Pseudomonas sp. However, the function of the styR gene in indigo synthesis and the detailed mechanisms through which StyR enhances the expression of the styAB operon are unclear. Accordingly, in this study, w...

journal_title：Biochemical and biophysical research communications

authors： Cheng L,Yue J,Yin S,Ren M,Wang C

更新日期：2019-10-29 00:00:00

abstract：:In the present study we used LLC-PK1 cells, a porcine renal proximal tubular cell line, to investigate whether PI3 kinase activation was involved in the anti-apoptotic effect of ouabain, a specific inhibitor of Na,K-ATPase. Apoptosis was induced by actinomycin D (Act D, 5 microM) and assessed by appearance of hypodipl...

journal_title：Biochemical and biophysical research communications

authors： Zhou X,Jiang G,Zhao A,Bondeva T,Hirszel P,Balla T

更新日期：2001-07-06 00:00:00

abstract：:Acyl-CoA thioesterases (ACOTs) catalyze the hydrolysis of CoA esters to free CoA and carboxylic acids and have important functions in lipid metabolism and other cellular processes. Type I ACOTs are found only in animals and contain an alpha/beta hydrolase domain, through currently no structural information is availabl...

journal_title：Biochemical and biophysical research communications

authors： Mandel CR,Tweel B,Tong L

更新日期：2009-08-07 00:00:00

abstract：:We have developed a new and rapid immunofluorescent method for visualisation of replicated regions on fixed DNA fibers. Using this method we have found in 5-fluorodeoxyuridine (FrdU)-blocked human cells distinct replication units covering about 60 kb of DNA and corresponding in size to single replicons or chromatin lo...

journal_title：Biochemical and biophysical research communications

authors： Tomilin N,Rosanov Yu,Zenin V,Bozhkov V,Vig B

更新日期：1993-01-15 00:00:00

abstract：:Hippocampal slices offer an excellent experimental system for the study of activity-induced changes in the postsynaptic density (PSD). While studies have documented electrophysiological and structural changes at synapses in response to precise manipulations of hippocampal slices, parallel biochemical and proteomic ana...

journal_title：Biochemical and biophysical research communications

authors： Dosemeci A,Tao-Cheng JH,Vinade L,Jaffe H

更新日期：2006-01-13 00:00:00

abstract：:Human Bruton's tyrosine kinase (hBtk) plays a key role in growth and metabolism of B cells, but its dysfunctions cause various B-cell malignancies. Inhibitors targeting the ATP-binding pocket of hBtk have been developed, but they have several drawbacks such as adverse side effects and occurrence of drug-resistant muta...

journal_title：Biochemical and biophysical research communications

authors： Jeong S,Sohn YK,Choi Y,Park J,Kim HS

更新日期：2020-05-21 00:00:00

abstract：:Transcription factors belonging to the CCAAT-enhancer binding protein (C/EBP) family have been implicated in the regulation of gene expression during growth, differentiation, apoptosis, and inflammation. Autoregulation is relatively common in the modulation of C/EBP gene expression and, for the human and murine C/EBPa...

journal_title：Biochemical and biophysical research communications

authors： Davies GE,Sabatakos G,Cryer A,Ramji DP

更新日期：2000-05-10 00:00:00

abstract：:Upon CNS damage, astrocytes undergo a series of biological changes including increased proliferation, production of inflammatory mediators and morphological changes, in a response collectively called reactive gliosis. This process is an essential part of the brains response to injury, yet much is unknown about the mol...

journal_title：Biochemical and biophysical research communications

authors： Kim KC,Hyun Joo S,Shin CY

更新日期：2011-06-17 00:00:00

abstract：:Huntington's disease (HD) is caused by mutations that expand a polyglutamine region in the amino-terminal domain of Huntingtin (Htt), leading to the accumulation of intracellular inclusions and progressive neurodegeneration. Recent reports indicate the engagement of endoplasmic reticulum (ER) stress responses in human...

journal_title：Biochemical and biophysical research communications

authors： Zuleta A,Vidal RL,Armentano D,Parsons G,Hetz C

更新日期：2012-04-13 00:00:00

abstract：:The death of cardiomyocytes after myocardial infarction (MI) often leads to ventricular remodeling as well as heart failure (HF). The cardiac progenitor cells (CPCs) have the ability to regenerate functional heart muscle in patients after MI, which provides a promising method for MI-induced HF therapy. However, to dat...

journal_title：Biochemical and biophysical research communications

authors： Li L,Wang Q,Yuan Z,Chen A,Liu Z,Wang Z,Li H

更新日期：2018-05-15 00:00:00

abstract：:Ammonia-forming cytochrome c nitrite reductase from Sulfurospirillum deleyianum contains four covalently bound heme c groups/55 kDa subunit as determined by atomic absorption spectroscopy and the pyridine Fe(II)-hemochrome technique. Nitrite reductase was isolated from the membrane fraction as a monomer (M(r) 55 +/- 2...

journal_title：Biochemical and biophysical research communications

authors： Schumacher W,Hole U,Kroneck PM

更新日期：1994-11-30 00:00:00

abstract：:Recent evidence has revealed a novel signaling mechanism through which brown adipose tissue (BAT)-derived exosomal microRNAs (miRNAs) influence hepatic gene expression. Here, we uncover neuronal control of these miRNAs and identify exosomal miR-132-3p as a regulator of hepatic lipogenesis under cold stress conditions....

journal_title：Biochemical and biophysical research communications

authors： Kariba Y,Yoshizawa T,Sato Y,Tsuyama T,Araki E,Yamagata K

更新日期：2020-09-24 00:00:00

abstract：:A novel cDNA clone was isolated from a yeast Saccharomyces cerevisiae lambda gt11 cDNA library using rabbit anti-rat tropomyosin (TM30nm) polyclonal antibody (RTM8-2). It consists of an open reading frame of 951 bp, encoding 317 amino acid residues. The putative sequence recognized by RTM8-2 was present in Asn-235 to ...

journal_title：Biochemical and biophysical research communications

authors： Miyado K,Katsuki M,Taniguchi S

更新日期：1994-03-30 00:00:00

abstract：:By using a 45Ca2+ overlay technique, we found two calcium-binding proteins (CaBPs) abundant in bovine amniotic fluid, and named them CAAF1 (calcium-binding protein in amniotic fluid-1) and CAAF2. CAAF1 was identified as a novel S100 protein produced by fetal epidermal keratinocytes, squamous epithelial cells and polym...

journal_title：Biochemical and biophysical research communications

authors： Hitomi J,Maruyama K,Kikuchi Y,Nagasaki K,Yamaguchi K

更新日期：1996-11-21 00:00:00

abstract：:The fluorescence decay of adenosine in 1:1 glycol/water glass has been determined at 77K using narrow pulse (700 ps) laser excitation at 290 nm and fluorescence detection with a scanned narrow-gate (100 ps) fast sampler together with digital averaging. Data analysis by re-iterative non-linear least squares convolution...

journal_title：Biochemical and biophysical research communications

authors： Hart LP,Daniels M

更新日期：1989-07-31 00:00:00

abstract：:We have used electron paramagnetic resonance (EPR) to examine the structural impact of oxidizing specific methionine (M) side chains in calmodulin (CaM). It has been shown that oxidation of either M109 or M124 in CaM diminishes CaM regulation of the muscle calcium release channel, the ryanodine receptor (RyR), and tha...

journal_title：Biochemical and biophysical research communications

authors： McCarthy MR,Thompson AR,Nitu F,Moen RJ,Olenek MJ,Klein JC,Thomas DD

更新日期：2015-01-09 00:00:00

abstract：:Since urease of Helicobacter pylori is essential for its colonization, we focused attention on foodstuffs which inhibit the activity of this enzyme. Among plant-derived 77 foodstuff samples tested, some tea and rosemary extracts were found to clearly inhibit H. pylori urease in vitro. In particular, green tea extract ...

journal_title：Biochemical and biophysical research communications

authors： Matsubara S,Shibata H,Ishikawa F,Yokokura T,Takahashi M,Sugimura T,Wakabayashi K

更新日期：2003-10-24 00:00:00

abstract：:Phosphofructokinase-2 from rat liver is inhibited by phosphoenolpyruvate and ADP. Phosphoenolpyruvate reduces the maximum activity in respect to fructose-6-phosphate and ATP but does not give rise to complete inhibition of phosphofructokinase-2. ADP increases the apparent Michaelis constant of the enzyme for ATP and l...

journal_title：Biochemical and biophysical research communications

authors： Kretschmer M,Hofmann E

更新日期：1984-11-14 00:00:00

abstract：:Chronic kidney disease (CKD) has recently emerged as a major risk factor for cardiovascular pathology. CKD patients display accelerated atherosclerotic process, leading to circulatory complications. However, it is currently not clear how uremic conditions accelerate atherosclerosis. Apoptosis is an important homeostat...

journal_title：Biochemical and biophysical research communications

authors： Trécherel E,Godin C,Louandre C,Benchitrit J,Poirot S,Mazière JC,Massy ZA,Galmiche A

更新日期：2012-01-06 00:00:00

abstract：:The glycolytic inhibitor 2-deoxy-d-glucose (2DG) causes energy starvation, affecting cell viability in a wide range of cancer cell lines. To determine the action of 2DG in pancreatic cancer, we performed proteomic analysis of pancreatic cancer cell line after 2DG treatment. Eighty proteins showed differential expressi...

journal_title：Biochemical and biophysical research communications

authors： Ishino K,Kudo M,Peng WX,Kure S,Kawahara K,Teduka K,Kawamoto Y,Kitamura T,Fujii T,Yamamoto T,Wada R,Naito Z

更新日期：2018-06-27 00:00:00

abstract：:In Wernicke's encephalopathy and thiamine deficiency (TD), the cause of this brain disorder, development of inflammation is an important aspect of the disease process. How this pathological mechanism relates to the neurologic impairment associated with TD, however, remains unclear. A key feature of the inflammatory pr...

journal_title：Biochemical and biophysical research communications

authors： Wang D,Hazell AS

更新日期：2010-11-05 00:00:00

abstract：:A phospholipase A2, which is immuno-crossreactive with the anti-rat pancreatic phospholipase A2 antibody, is present in rat gastric mucosa. The content of the enzyme in the gastric mucosa was comparable to that in the pancreas, but the specific activity in the gastric mucosa homogenate (60.7 +/- 19.5 nmol/min/mg) was ...

journal_title：Biochemical and biophysical research communications

authors： Tojo H,Ono T,Okamoto M

更新日期：1988-03-30 00:00:00

abstract：:Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials; however, it remains unclear whether AgNPs induce neurotoxicity. Here, we investigated the potential neurological effects of AgNPs and the neuroprotective effect of vitamin E (VE). We found that intranasal instillation of AgNPs in neonatal Sp...

journal_title：Biochemical and biophysical research communications

authors： Yin N,Yao X,Zhou Q,Faiola F,Jiang G

更新日期：2015-03-06 00:00:00

abstract：:Inositol 1,2,3,5,6-pentakisphosphate (Ins(1,2,3,5,6)P5) 5-phosphatase present in fetal calf thymus has been partially purified. This enzyme was inhibited dose-dependently by different thiol modifiers like N-ethylmaleimide (NEM), p-chloromercuribenzene sulfonate (PCMBS), diamide, and phenylarsine oxide (PAO). The inhib...

journal_title：Biochemical and biophysical research communications

authors： Bandyopadhyay U,Kaiser T,Rudolf MT,Schultz C,Guse AH,Mayr GW

更新日期：1997-11-07 00:00:00