A pancreatic-type phospholipase A2 in rat gastric mucosa.

abstract：:Reactive oxygen species such as hydrogen peroxide (H(2)O(2)) have taken center stage as bona fide second messengers in various signaling pathways. Here, we report the synthesis, metabolic fate, and effectiveness in modulating such pathways of a Tat-catalase conjugate. Incubation of L2 cells with Tat-catalase greatly i...

journal_title：Biochemical and biophysical research communications

authors： Watanabe N,Iwamoto T,Bowen KD,Dickinson DA,Torres M,Forman HJ

更新日期：2003-03-28 00:00:00

abstract：:Rodent brown adipocytes express peroxisome proliferator activated receptor-alpha (PPARalpha) and PPARgamma and while the rodent uncoupling protein-1 (UCP-1) gene contains a putative peroxisome proliferator response element (PPRE), only PPARgamma activation by thiazolidinediones increase UCP-1 mRNA levels. We have inve...

journal_title：Biochemical and biophysical research communications

authors： Teruel T,Clapham JC,Smith SA

更新日期：1999-10-22 00:00:00

abstract：:We have developed a novel vector system for the efficient assembly of polydactyl zinc fingers. Next to proteins that possess short canonical TGEKP linkers between all constituting zinc fingers we constructed proteins with longer, 12 amino acid linkers between two three-finger (3F) units and between three two-finger (2...

journal_title：Biochemical and biophysical research communications

authors： Neuteboom LW,Lindhout BI,Saman IL,Hooykaas PJ,van der Zaal BJ

更新日期：2006-01-06 00:00:00

abstract：:The (45)Ca(2+) influx into right-side-out resealed ghosts (RG) prepared from human red blood cells (RBC) was measured. The (45)Ca(2+) equilibration occurred with t(1/2)=2.5 min and the steady-state was reached after 17 min with the level of 22+/-2 micromol/L(packed cells) at 37 degrees C. The rate of the influx was 97...

journal_title：Biochemical and biophysical research communications

authors： Hudec R,Lakatos B,Orlický J,Varecka L

更新日期：2004-12-24 00:00:00

abstract：:Polyclonal antibodies (pAbs) to riboflavin carrier protein (RCP) purified from human amniotic fluid were raised in two rabbits. These pAbs apart from recognizing the parent antigen, reacted significantly with chicken RCP as well. When all the 212 octapeptides overlapping by one amino acid residue and covering the enti...

journal_title：Biochemical and biophysical research communications

authors： Subramanian S,Adiga PR

更新日期：1999-08-27 00:00:00

abstract：:Heme is central to oxygen sensing and utilization in all living organisms. It directly regulates numerous molecular and cellular processes for systems that sense or use oxygen. In mammals, heme plays an indispensable role in erythroid cell differentiation. To investigate heme regulatory functions, we identified, by di...

journal_title：Biochemical and biophysical research communications

authors： Zhu Y,Hon T,Zhang L

更新日期：1999-04-29 00:00:00

abstract：:We have isolated cDNAs from normal human breast tissue and breast tumour cells that encode a protein (pez) with features of a novel non-receptor tyrosine phosphatase possessing N-terminal sequence homology to the ezrin-band 4.1-merlin-radixin protein family. Northern blot analysis indicates that pez is expressed in a ...

journal_title：Biochemical and biophysical research communications

authors： Smith AL,Mitchell PJ,Shipley J,Gusterson BA,Rogers MV,Crompton MR

更新日期：1995-04-26 00:00:00

abstract：:The only outer mitochondrial membrane cytochrome b(5) examined to date, from rat (rOM b(5)), exhibits greater stability than known mammalian microsomal (Mc) isoforms, as well as a much higher kinetic barrier for hemin dissociation and a more negative reduction potential. A BlastP search of available databases using th...

journal_title：Biochemical and biophysical research communications

authors： Altuve A,Wang L,Benson DR,Rivera M

更新日期：2004-02-06 00:00:00

abstract：:Here we investigate the effects of the dihydropyridine-type antagonists of calcium channels nitrendipine, nimodipine, nisoldipine and the calcium channel agonist BAY K 8644 on the induction of nitric oxide synthase (NOS) by bacterial endotoxin (lipopolysaccharide; LPS) in J774.2 macrophages cultured in vitro. Pretreat...

journal_title：Biochemical and biophysical research communications

authors： Szabó C,Thiemermann C,Vane JR

更新日期：1993-10-29 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been isolated from various tissues and used for elucidating the pathogenesis of numerous diseases. In our previous in vitro study, we showed the existence of MSCs in human spinal ligaments and hypothesized that these MSCs contributed to the pathogenesis of ossification of spinal liga...

journal_title：Biochemical and biophysical research communications

authors： Chin S,Furukawa K,Ono A,Asari T,Harada Y,Wada K,Tanaka T,Inaba W,Mizukami H,Motomura S,Yagihashi S,Ishibashi Y

更新日期：2013-07-12 00:00:00

abstract：:Most human cancers are of epithelial origin, but many cell culture models for the study of cancer-causing genes use fibroblasts. In addition, efficient delivery and stable expression of foreign genes into non-transformed cell lines are often difficult. To address both questions, we here established a non-transformed r...

journal_title：Biochemical and biophysical research communications

authors： Fu SL,Huang YJ,Liang FP,Huang YF,Chuang CF,Wang SW,Yao JW

更新日期：2005-12-16 00:00:00

abstract：:Peroxynitrite-mediated oxidation of ferrous nitrosylated myoglobin (Mb(II)-NO) involves the transient ferric nitrosylated species (Mb(III)-NO), followed by ()NO dissociation and formation of ferric myoglobin (Mb(III)). In contrast, peroxynitrite-mediated oxidation of ferrous oxygenated myoglobin (Mb(II)-O2) involves t...

journal_title：Biochemical and biophysical research communications

authors： Ascenzi P,Ciaccio C,Coletta M

更新日期：2007-11-30 00:00:00

abstract：:Brush border membrane vesicles (BBMVs) prepared from midguts of Choristoneura fumiferana larvae were pretreated separately with the three CryIA delta-endotoxins from Bacillus thuringiensis subsp. kurstaki HD-1. Crossed affinity immunoelectrophoresis of the solubilized toxin-BBMV complexes, using antibodies raised agai...

journal_title：Biochemical and biophysical research communications

authors： Pang AS

更新日期：1994-03-30 00:00:00

abstract：:Free D-aspartic acid is present in appreciable quantities in the brain and other tissues of rodents and in human blood. In the newborn rat, the highest concentration of D-aspartic acid was found in cerebral hemispheres, where, at 164 nmol/g (8.4% of the total aspartic acid), the level of D-aspartic acid exceeds that o...

journal_title：Biochemical and biophysical research communications

authors： Dunlop DS,Neidle A,McHale D,Dunlop DM,Lajtha A

更新日期：1986-11-26 00:00:00

abstract：:To explore the mechanism of glucocorticoid-induced osteoporosis, we investigated the effect of glucocorticoid on canonical Wnt signaling that emerged as a novel key pathway for promoting bone formation. Wnt3a increased the T-cell factor (Tcf)/lymphoid enhancer factor (Lef)-dependent transcriptional activity in primary...

journal_title：Biochemical and biophysical research communications

authors： Ohnaka K,Tanabe M,Kawate H,Nawata H,Takayanagi R

更新日期：2005-04-01 00:00:00

abstract：:The role of inducible nitric oxide synthase (iNOS) in the progression of fibrosis during nonalcoholic steatohepatitis remains to be elucidated. This study examined the role of iNOS in the progression of fibrosis during steatohepatitis by comparing iNOS knockout (iNOS(-/-)) and wild-type (iNOS(+/+)) mice that were fed ...

journal_title：Biochemical and biophysical research communications

authors： Chen Y,Hozawa S,Sawamura S,Sato S,Fukuyama N,Tsuji C,Mine T,Okada Y,Tanino R,Ogushi Y,Nakazawa H

更新日期：2005-01-07 00:00:00

abstract：:Type 2 diabetes mellitus is thought to be partially associated with endoplasmic reticulum (ER) stress toxicity on pancreatic beta cells and the result of decreased insulin synthesis and secretion. In this study, we showed that a well-known insulin sensitizer, metformin, directly protects against dysfunction and death ...

journal_title：Biochemical and biophysical research communications

authors： Jung TW,Lee MW,Lee YJ,Kim SM

更新日期：2012-01-06 00:00:00

abstract：:We report the characterization of a new member of the low-density lipoprotein receptor (LDLR) gene family designated LRP10. Human LRP10 cDNA encodes a 1905 amino acid type I membrane protein consisting of five functional domains characteristic of the LDLR gene family. CHO-ldlA7 cells transfected with human LRP10 cDNA ...

journal_title：Biochemical and biophysical research communications

authors： Jeong YH,Ishikawa K,Someya Y,Hosoda A,Yoshimi T,Yokoyama C,Kiryu-Seo S,Kang MJ,Tchibana T,Kiyama H,Fukumura T,Kim DH,Saeki S

更新日期：2010-01-01 00:00:00

abstract：:In this work we have investigated the transfer of radioactive palmitic acid between membrane phospholipids and acyl-L-carnitines in intact human erythrocytes. During the incubation period of labeled erythrocyte in non-defatted bovine serum albumin, radioactivity in phosphatidylcholine and phosphatidylethanolamine incr...

journal_title：Biochemical and biophysical research communications

authors： Arduini A,Tyurin V,Tyuruna Y,Arrigoni-Martelli E,Molajoni F,Dottori S,Federici G

更新日期：1992-08-31 00:00:00

abstract：:Planar cell polarity (PCP) signaling controls polarized behaviors in diverse tissues, including the collective cell movements of gastrulation and the planar polarized beating of motile cilia. A major question in PCP signaling concerns the mechanisms linking this signaling cascade with more general cytoskeletal element...

journal_title：Biochemical and biophysical research communications

authors： Park TJ,Kim SK,Wallingford JB

更新日期：2015-01-09 00:00:00

abstract：:N1999A2 (NA2) is a new non-protein antitumor antibiotic that contains a stable 9-membered ring enediyne chromophore similar to a neocarzinostatin chromophore (NCS-chr). We have compared DNA cleavage reactions between NA2 and NCS-chr, and also clarified some characteristics of DNA strand scission by NA2. It was found t...

journal_title：Biochemical and biophysical research communications

authors： Miyagawa N,Sasaki D,Matsuoka M,Imanishi M,Ando T,Sugiura Y

更新日期：2003-06-20 00:00:00

abstract：:In a recent publication [Biochem. Biophys. Res. Commun. 317 (2004) 957] it was proposed that the 'effective number of codons' (Nc) in a gene should be calculated by summing the individual amino acid Nc's using rounding whenever the codon homozygosities are lower than the reciprocal value of the number of members of th...

journal_title：Biochemical and biophysical research communications

authors： Fuglsang A

更新日期：2005-02-04 00:00:00

abstract：:The presence of cancer stem cells, in both hematopoietic and solid malignancies, has been recently linked to their pathogenesis. We aimed to identify the characteristics and stem-like properties of sphere-colony forming cells in rat osteosarcoma and malignant fibrous histiocytoma cell lines. The results showed that bo...

journal_title：Biochemical and biophysical research communications

authors： Fujii H,Honoki K,Tsujiuchi T,Kido A,Yoshitani K,Mori T,Takakura Y

更新日期：2007-10-26 00:00:00

abstract：:Glial precursor cells (GPCs) are present in the adult human central nervous system (CNS) and they can be isolated and maintained in culture for in vitro studies. This study analysed expression of mGluR3 and mGluR5 metabotropic glutamate receptor (mGluR) mRNAs in GPCs. A2B5 surface antigen positive GPCs were isolated u...

journal_title：Biochemical and biophysical research communications

authors： Luyt K,Varadi A,Halfpenny CA,Scolding NJ,Molnar E

更新日期：2004-06-18 00:00:00

abstract：:Odorant binding proteins (OBPs) contribute to the remarkable sensitivity of the insect's olfactory system and play important roles in the olfactory recognition. The orange blossom midge, Sitodiplosis mosellana is a cereal specialist, and utilizes pheromone and host odorant as a cue for its mating and oviposition. Howe...

journal_title：Biochemical and biophysical research communications

authors： Gong ZJ,Miao J,Duan Y,Jiang YL,Li T,Wu YQ

更新日期：2014-02-07 00:00:00

abstract：:Here we report that we could obtain a highly differentiated smooth muscle cell line by screening the expression of a-smooth muscle actin from p53 knook out mice aorta. This cell revealed extended bipolar shape and expressed h-caldesmon and calponin as well as a-smooth muscle actin as protein markers of differentiated ...

journal_title：Biochemical and biophysical research communications

authors： Ohmi K,Masuda T,Yamaguchi H,Sakurai T,Kudo Y,Katsuki M,Nonomura Y

更新日期：1997-09-08 00:00:00

abstract：:We have determined the identity of the orphan G-protein coupled receptor cDNA, 6H1, present in activated chicken T cells, as a subtype of P2Y purinoceptor. This identification is based on first on the degree of sequence identity shared with recently cloned members of the P2Y receptor family and second on the pharmacol...

journal_title：Biochemical and biophysical research communications

authors： Webb TE,Kaplan MG,Barnard EA

更新日期：1996-02-06 00:00:00

abstract：:Recent studies have reported elevated expression of miR-181a in patients with non-alcoholic fatty liver disease (NAFLD), suggesting that it may play an important role in liver lipid metabolism and insulin resistance. We aimed to investigate the effect of miR-181a in lipid metabolism and find new treatments for NAFLD. ...

journal_title：Biochemical and biophysical research communications

authors： Huang R,Duan X,Liu X,Cao H,Wang Y,Fan J,Wang B

更新日期：2019-01-22 00:00:00

abstract：:Murine cell-derived MLV vector particles usually are highly sensitive to human complement-mediated lysis. Expression of the human complement inhibitor CD59 on murine packaging cells resulted in partial protection of these cells from lysis caused by human complement proteins. Furthermore, CD59 was incorporated into MLV...

journal_title：Biochemical and biophysical research communications

authors： Breun S,Salmons B,Günzburg WH,Baumann JG

更新日期：1999-10-14 00:00:00

abstract：:Cyclo-oxygenase (COX) exists as two isoforms. In endothelial cells, the induction of COX (COX-2) elicited by endotoxin or inflammatory cytokines is mediated by tyrosine kinase. Here we have investigated whether the induction of COX-2 elicited by IL-1beta in human pulmonary epithelial cells (A549) is mediated by tyrosi...

journal_title：Biochemical and biophysical research communications

authors： Akarasereenont P,Thiemermann C

更新日期：1996-03-07 00:00:00