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Effects of different zinc finger transcription factors on genomic targets.

Abstract：

:We have developed a novel vector system for the efficient assembly of polydactyl zinc fingers. Next to proteins that possess short canonical TGEKP linkers between all constituting zinc fingers we constructed proteins with longer, 12 amino acid linkers between two three-finger (3F) units and between three two-finger (2F) units. Fusions of these zinc finger domains with the VP16 activation domain were tested for their ability to regulate a repressed genomic locus containing contiguous or noncontiguous zinc finger binding sites in yeast. In contrast to other studies, which were mostly confined to in vitro tests, we did not obtain evidence that superior artificial zinc finger transcription factors need to contain longer linkers between individual fingers. For the regulation of genomic loci, canonical linkers within a highly regular backbone in combination with a contiguous 18 base pair DNA target site were found to provide a sound base for polydactyl zinc finger design.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Neuteboom LW,Lindhout BI,Saman IL,Hooykaas PJ,van der Zaal BJ

doi

10.1016/j.bbrc.2005.11.011

subject

Has Abstract

pub_date

2006-01-06 00:00:00

pages

263-70

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)02524-6

journal_volume

339

pub_type

杂志文章

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