2,3,7,8-Tetrachlorodibenzo-p-dioxin increases reliance on fats as a fuel source independently of diet: evidence that diminished carbohydrate supply contributes to dioxin lethality.

abstract：:Stimulation of cultured hypothalamic slices with PRL causes a rapid translocation of a Ca2+/phospholipid dependent protein kinase from the cytosol to the membrane fraction. The translocation of PKC from the cytosol to the membrane occurred at physiological concentrations of PRL with a maximal response occurring at 10(...

journal_title：Biochemical and biophysical research communications

authors： DeVito WJ,Stone S,Avakian C

更新日期：1991-04-30 00:00:00

abstract：:Runt-related transcription factor 2 (Runx2), also known as core binding factor 1 (Cbfa1), is a multifunctional transcription factor and an essential master gene controlling osteoblast differentiation. We previously demonstrated the in vivo functions of Runx2 in mesoderm-derived cells. However, no studies have been con...

journal_title：Biochemical and biophysical research communications

authors： Shirai Y,Kawabe K,Tosa I,Tsukamoto S,Yamada D,Takarada T

更新日期：2019-02-19 00:00:00

abstract：:Obesity continues to be one of the most prominent public health dilemmas in the world. The complex interaction among the varied causes of obesity makes it a particularly challenging problem to address. While typical high-fat purified diets successfully induce weight gain in rodents, we have described a more robust mod...

journal_title：Biochemical and biophysical research communications

authors： Johnson AR,Wilkerson MD,Sampey BP,Troester MA,Hayes DN,Makowski L

更新日期：2016-04-29 00:00:00

abstract：:Overexpression in Escherichia coli of the fdx4 gene from Aquifex aeolicus has allowed isolation and characterization of the first hyperthermophilic [2Fe-2S](Scys)(4) protein, a homodimer of M = 2 x 12.4 kDa with one [2Fe-2S] cluster per subunit. This protein is undamaged by heating to 100 degrees C for at least three ...

journal_title：Biochemical and biophysical research communications

authors： Chatelet C,Gaillard J,Pétillot Y,Louwagie M,Meyer J

更新日期：1999-08-11 00:00:00

abstract：:The Fru-6-P/Fru-2,6-P2 exchange reaction of rat liver 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase was almost entirely dependent on the presence of Pi. This exchange was not due to a reversal of the bisphosphatase nor to trace amounts of adenine nucleotide in the enzyme. Exchange activity was maximal at pH 7, ...

journal_title：Biochemical and biophysical research communications

authors： El-Maghrabi MR,Pate TM,Pilkis SJ

更新日期：1984-09-17 00:00:00

abstract：:(-)Bay K 8644 produced a concentration-dependent contraction of porcine coronary artery rings with the maximal contraction at 10(-6) M. Pretreatment of the rings with 10(-6) M nitrendipine inhibited (-)Bay K 8644-induced contraction, while pretreatment with 10(-8) M nitrendipine potentiated the contraction elicited by...

journal_title：Biochemical and biophysical research communications

authors： Miwa K,Schwartz A

更新日期：1987-10-14 00:00:00

abstract：:Co3O4 nanoparticles (NPs) are one kind of the important nanomaterials that have the application potential in catalyst, electrochromic devices, sensors, etc. However, their biological effect remains to be detailed. In this study, we investigated the effect of the as-synthesized Co3O4 NPs (15-30 nm) on the growth of mam...

journal_title：Biochemical and biophysical research communications

authors： Wang H,Ren T,Zhu N,Yu Q,Li M

更新日期：2018-11-02 00:00:00

abstract：:DNA mismatch repair (MMR) is critical for the maintenance of genomic stability. MMR is initiated by recognition of DNA mismatches by the protein, MutS, which subsequently recruits downstream repair factors. To better understand the mechanism by which MutS identifies and specifically binds mismatched basepairs embedded...

journal_title：Biochemical and biophysical research communications

authors： Jia Y,Bi L,Li F,Chen Y,Zhang C,Zhang X

更新日期：2008-08-08 00:00:00

abstract：:To understand the role of cysteine (SH) residues in the folding of hen ovalbumin (OVA), SH-mutated OVAs, in which each SH residue was replaced by alanine (C11A, C30A, C367A, and C382A), were prepared. SDS-PAGE analysis under non-reducing conditions showed that the C11A and C30A mutants produced a disulfide (SS) isomer...

journal_title：Biochemical and biophysical research communications

authors： Ishimaru T,Ito K,Tanaka M,Matsudomi N

更新日期：2018-01-01 00:00:00

abstract：:Insulin-stimulated GLUT4 recruitment to the plasma membrane is impaired in insulin resistance. We recently reported that a cell permeable phosphoinositide-binding peptide induces GLUT4 recruitment as potently as insulin, but does not activate GLUT4 to initiate glucose uptake. Here we investigated whether the peptide-i...

journal_title：Biochemical and biophysical research communications

authors： Funaki M,Benincasa K,Randhawa PK

更新日期：2007-09-07 00:00:00

abstract：:Signaling by stem cell factor and Kit, its receptor, play important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human and mouse embryonic stem cells express Kit transcripts. Stem cell factor exists as both a soluble and a membrane-bound glycoprotein while Kit...

journal_title：Biochemical and biophysical research communications

authors： Roskoski R Jr

更新日期：2005-12-23 00:00:00

abstract：:Pyruvate dehydrogenase kinase isoform 4 (PDK4) is upregulated by starvation in many tissues of the body during starvation. This causes inactivation of the pyruvate dehydrogenase complex which blocks pyruvate oxidation and conserves lactate and alanine for gluconeogenesis. Enhanced PDK4 expression may be caused by the ...

journal_title：Biochemical and biophysical research communications

authors： Wu P,Peters JM,Harris RA

更新日期：2001-09-21 00:00:00

abstract：:Proteins modified by oxidants are rapidly degraded by intracellular proteases. Oxidatively modified superoxide dismutase (Ox-SOD) was degraded 2-8 times faster at both acidic and alkaline pH than the native protein in bovine cardiac tissue extracts. At acidic pH, Ox-SOD hydrolysis was stimulated by ATP and by non-hydr...

journal_title：Biochemical and biophysical research communications

authors： Strack PR,Waxman L,Fagan JM

更新日期：1996-02-15 00:00:00

abstract：:Here we investigate the effects of the dihydropyridine-type antagonists of calcium channels nitrendipine, nimodipine, nisoldipine and the calcium channel agonist BAY K 8644 on the induction of nitric oxide synthase (NOS) by bacterial endotoxin (lipopolysaccharide; LPS) in J774.2 macrophages cultured in vitro. Pretreat...

journal_title：Biochemical and biophysical research communications

authors： Szabó C,Thiemermann C,Vane JR

更新日期：1993-10-29 00:00:00

abstract：:The uptake of a photolabile taurocholate derivative, (7,7-azo-3 alpha, 12 alpha-dihydroxy-5 beta-cholan-24-oyl)-2-aminoethanesulfonate, 7,7-azo-TC, into rat renal brush-border membrane vesicles was stimulated by Na+ and inhibited by taurocholate indicating an interaction with the Na+/bile salt cotransport system. Irra...

journal_title：Biochemical and biophysical research communications

authors： Burckhardt G,Kramer W,Kurz G,Wilson FA

更新日期：1987-03-30 00:00:00

abstract：:F(0)F(1)-ATPase within chromatophore was constructed as a biosensor (immuno-rotary biosensor) for the purpose of capturing single virus. Capture of virus was based on antibody-antigen reaction. The detection of virus based on proton flux change driven by ATP-synthesis of F(0)F(1)-ATPase, which was indicated by F1300, ...

journal_title：Biochemical and biophysical research communications

authors： Liu X,Zhang Y,Yue J,Jiang P,Zhang Z

更新日期：2006-04-21 00:00:00

abstract：:Alzheimer's disease (AD) pathology is characterized by plaques, tangles, and neuronal cell loss. The main constituent of plaques is beta-amyloid peptide (A beta), a 39-42 residue peptide which has been linked to disruption of calcium homeostasis and neurotoxicity in vitro. We demonstrate that a neurotoxic fragment of ...

journal_title：Biochemical and biophysical research communications

authors： Mirzabekov T,Lin MC,Yuan WL,Marshall PJ,Carman M,Tomaselli K,Lieberburg I,Kagan BL

更新日期：1994-07-29 00:00:00

abstract：:In this study, we calculate the unpredictable portion of amino-acid pairs, which has been developed by us over the last several years, of 1201 hemagglutinins from influenza A viruses dated from 1918 to 2004 in order to compare them with respect to subtypes, species, and years. After noticing the fluctuations of unpred...

journal_title：Biochemical and biophysical research communications

authors： Wu G,Yan S

更新日期：2005-07-22 00:00:00

abstract：:This study evaluates the influence of S1033 vinculin phosphorylation on the mechanical properties of cells. We demonstrate that MEFvcl KO cells transfected with the non-phosphorylatable eGFP-vinculin mutant S1033A are of lower stiffness compared to MEFvcl Rescue and phospho-mimicking mutant S1033D cells, which were of...

journal_title：Biochemical and biophysical research communications

authors： Auernheimer V,Goldmann WH

更新日期：2014-07-25 00:00:00

abstract：:The anomeric proton of the reducing N-acetylglucosamine residue of beta-N,N'-diacetylchitobiose exhibited an unusual lineshape indicative of virtual coupling in the 250 MHz proton NMR spectrum. The two-dimensional J-resolved spectrum contained four lines associated with this proton, and this pattern can be used to dis...

journal_title：Biochemical and biophysical research communications

authors： Bruch RC,Bruch MD,Noggle JH,White HB 3rd

更新日期：1984-09-17 00:00:00

abstract：:p47-phox is one of the cytosolic activation factors of NADPH oxidase in neutrophils and known to translocate to plasma membranes and function by protein kinase C-phosphorylation. In cytosol fraction, prepared from calyculin A-treated neutrophils, the activity of cytosolic factor to activate NADPH oxidase was more redu...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi M,Saeki S,Yamane H,Okamura N,Ishibashi S

更新日期：1995-11-02 00:00:00

abstract：:Aurora-C, a member of the Aurora kinase family, is implicated in the regulation of mitosis. In contrast to Aurora-A and Aurora-B its cellular localization and functions are poorly characterized. TACC1 protein belongs to the transforming acidic coiled-coil family shown to interact with the Aurora kinases. In the presen...

journal_title：Biochemical and biophysical research communications

authors： Gabillard JC,Ulisse S,Baldini E,Sorrenti S,Cremet JY,Coccaro C,Prigent C,D'Armiento M,Arlot-Bonnemains Y

更新日期：2011-05-20 00:00:00

abstract：:Cells have developed compensatory mechanisms to restore cell volume, and the ability to resist osmotic swelling or shrinkage parallels their resistance to necrosis or apoptosis. There are several mechanisms by which cells adapt to hyposmotic stress including that of regulatory volume decrease. In ischemia and reperfus...

journal_title：Biochemical and biophysical research communications

authors： Díaz-Elizondo J,Chiong M,Rojas-Rivera D,Olea-Azar C,Kwon HM,Lavandero S

更新日期：2006-12-01 00:00:00

abstract：:Using baculoviral and bacterial systems, we expressed biologically active recombinant rat IL-13 and generated neutralizing rat IL-13 antiserum. Recombinant rat IL-13 produced by baculovirus-infected insect cells stimulated proliferation of TF-1 premyeloid cell line and induced expression of 15-lipoxygenase mRNA in hum...

journal_title：Biochemical and biophysical research communications

authors： Lakkis FG,Cruet EN,Nassar GM,Badr KF,Pascual DW

更新日期：1997-06-27 00:00:00

abstract：:It has been shown that anti-cancer drug induces secretion of serotonin (5-HT) from small intestine which activates serotonin type 3 (5-HT(3)) receptor to cause nausea and vomiting. In general, antagonist for 5-HT(3) receptor is used as anti-emetics during chemotherapy. However, we found that anti-cancer drug irinoteca...

journal_title：Biochemical and biophysical research communications

authors： Nakamura Y,Ishida Y,Yamada T,Shimada S

更新日期：2011-11-18 00:00:00

abstract：:In the presence of copper (Cu), disulfiram (DSF) suppresses properties associated with cancer stem cells (CSCs) in breast cancer, but the mechanism of action is poorly understood. In the present study, we observed that DSF/Cu treatment induced apoptosis, mediated by caspase-3 activation in triple-negative breast cance...

journal_title：Biochemical and biophysical research communications

authors： Kim YJ,Kim JY,Lee N,Oh E,Sung D,Cho TM,Seo JH

更新日期：2017-05-13 00:00:00

abstract：:Human Protein tyrosine kinase 6 (PTK6)(EC:2.7.10.2), also known as the breast tumor kinase (BRK), is an intracellular non-receptor Src-related tyrosine kinase expressed five-fold or more in human breast tumors and breast cancer cell lines but its expression being low or completely absent from normal mammary gland. The...

journal_title：Biochemical and biophysical research communications

authors： Thakur MK,Birudukota S,Swaminathan S,Battula SK,Vadivelu S,Tyagi R,Gosu R

更新日期：2017-01-22 00:00:00

abstract：:Mouse monoclonal antibodies were generated against human ribonuclease inhibitor, an intracellular regulatory protein. A total of four antibodies were isolated, all of which were of the immunoglobulin G1 subtype. Western blot analysis of the antibodies suggested monospecificity. Based on immunoradiometric competition a...

journal_title：Biochemical and biophysical research communications

authors： Feldman M,Kohtz DS,Kleinberg DL

更新日期：1988-11-30 00:00:00

abstract：:This report describes a procedure to generate enzymatically active, isolated HIV RNase H domain. In contrast to previously described preparations, the RNA cleavage activity of the untagged RNase H domain was surprisingly similar to that of the full-length HIV-RT protein. Signature cleavages at 18 and 9 nucleotides dow...

journal_title：Biochemical and biophysical research communications

authors： Hang JQ,Rajendran S,Yang Y,Li Y,In PW,Overton H,Parkes KE,Cammack N,Martin JA,Klumpp K

更新日期：2004-04-30 00:00:00

abstract：:We examined the possible participation of nitric oxide (NO) in the activation of cyclooxygenase, a heme-containing enzyme, induced by interleukin-1 (IL-1) in vascular smooth muscle cells (VSMC). IL-1 induced a delayed and prolonged release of both NO and prostaglandin E2 (PGE2) from VSMC. NG-monomethyl-L-arginine (L-N...

journal_title：Biochemical and biophysical research communications

authors： Inoue T,Fukuo K,Morimoto S,Koh E,Ogihara T

更新日期：1993-07-15 00:00:00