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Reduced expression of INK4a/ARF genes in stem-like sphere cells from rat sarcomas.

Abstract：

:The presence of cancer stem cells, in both hematopoietic and solid malignancies, has been recently linked to their pathogenesis. We aimed to identify the characteristics and stem-like properties of sphere-colony forming cells in rat osteosarcoma and malignant fibrous histiocytoma cell lines. The results showed that both cell lines possessed an ability to form spherical, clonally expanding colonies in anchorage-independent, serum-starved conditions in N2/1% methylcellulose medium. The sphere cells showed stem-like properties with the ability to self-renew, and expressed the stem cell-related STAT3 and Bmi1 genes. Interestingly, spheres from both sarcomas remarkably decreased the expression of INK4a/ARF locus genes, p16(INK4a) and p19(ARF), which could be related to the resistance against cell senescence and apoptosis. Spheres showed strong tumorigenicity with metastatic potential in vivo via the inoculation into syngeneic rats, suggesting the presence of these populations might contribute to the tumor development such as metastasis via the resistance to apoptotic stimuli.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Fujii H,Honoki K,Tsujiuchi T,Kido A,Yoshitani K,Mori T,Takakura Y

doi

10.1016/j.bbrc.2007.08.067

subject

Has Abstract

pub_date

2007-10-26 00:00:00

pages

773-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)01784-6

journal_volume

362

pub_type

杂志文章

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