Granulins, a novel class of peptide from leukocytes.

Abstract:

:We report the isolation and characterization of a novel class of leukocyte peptides with possible cytokine-like activities which we call granulins. They are cystine-rich with molecular weights of approximately 6 Kda, except for granulin D, which appears to be a dimer. We present the sequence of one member of this family, a 56 residue peptide, granulin A, and amino-terminal sequences for three other granulins from human peripheral leukocytes. A fifth related peptide was isolated and partially sequenced from rat bone marrow, suggesting that at least some of the granulin in peripheral leukocytes is preformed in the marrow. Rat granulin, and human granulin A, are closely related, showing that the granulin structures are highly conserved between species.

authors

Bateman A,Belcourt D,Bennett H,Lazure C,Solomon S

doi

10.1016/s0006-291x(05)80908-8

subject

Has Abstract

pub_date

1990-12-31 00:00:00

pages

1161-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)80908-8

journal_volume

173

pub_type

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