Abstract:
:We report the isolation and characterization of a novel class of leukocyte peptides with possible cytokine-like activities which we call granulins. They are cystine-rich with molecular weights of approximately 6 Kda, except for granulin D, which appears to be a dimer. We present the sequence of one member of this family, a 56 residue peptide, granulin A, and amino-terminal sequences for three other granulins from human peripheral leukocytes. A fifth related peptide was isolated and partially sequenced from rat bone marrow, suggesting that at least some of the granulin in peripheral leukocytes is preformed in the marrow. Rat granulin, and human granulin A, are closely related, showing that the granulin structures are highly conserved between species.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Bateman A,Belcourt D,Bennett H,Lazure C,Solomon Sdoi
10.1016/s0006-291x(05)80908-8subject
Has Abstractpub_date
1990-12-31 00:00:00pages
1161-8issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(05)80908-8journal_volume
173pub_type
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