Granulins, a novel class of peptide from leukocytes.


:We report the isolation and characterization of a novel class of leukocyte peptides with possible cytokine-like activities which we call granulins. They are cystine-rich with molecular weights of approximately 6 Kda, except for granulin D, which appears to be a dimer. We present the sequence of one member of this family, a 56 residue peptide, granulin A, and amino-terminal sequences for three other granulins from human peripheral leukocytes. A fifth related peptide was isolated and partially sequenced from rat bone marrow, suggesting that at least some of the granulin in peripheral leukocytes is preformed in the marrow. Rat granulin, and human granulin A, are closely related, showing that the granulin structures are highly conserved between species.


Bateman A,Belcourt D,Bennett H,Lazure C,Solomon S




Has Abstract


1990-12-31 00:00:00














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    abstract::In the present study, we demonstrated that there is a direct relationship between scratching behaviors induced by itch and functional changes in the brain reward system. Using a conditional place preference test, the rewarding effect was clearly evoked by scratching under both acute and chronic itch stimuli. The induc...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Setsu T,Hamada Y,Oikawa D,Mori T,Ishiuji Y,Sato D,Narita M,Miyazaki S,Furuta E,Suda Y,Sakai H,Ochiya T,Tezuka H,Iseki M,Inada E,Yamanaka A,Kuzumaki N,Narita M

    更新日期:2021-01-01 00:00:00

  • Targeting DUSP16/TAK1 signaling alleviates hepatic dyslipidemia and inflammation in high fat diet (HFD)-challenged mice through suppressing JNK MAPK.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is featured by hepatic steatosis, insulin resistance, lipid deposition and inflammation. However, the pathogenic mechanism of NAFLD is still poorly understood. Dual-specificity phosphatase 16 (DUSP16), a c-Jun N-terminal kinase-specific phosphatase, has been reported to negativ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Wu YK,Hu LF,Lou DS,Wang BC,Tan J

    更新日期:2020-03-26 00:00:00

  • Non-small cell lung cancer cells with deficiencies in homologous recombination genes are sensitive to PARP inhibitors.

    abstract::Lung cancer is the leading cause of cancer death worldwide. PARP inhibitors have become a new line of cancer therapy and a successful demonstration of the synthetic lethality concept. The mechanism and efficacy of PARP inhibitors have been well studied in some cancers, especially homologous recombination (HR)-deficien...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Ji W,Weng X,Xu D,Cai S,Lou H,Ding L

    更新日期:2020-01-29 00:00:00

  • Leucine-rich repeat-containing G-protein coupled receptor 5 enriched organoids under chemically-defined growth conditions.

    abstract::An organoid is a complex, multi-cell three-dimensional (3D) structure that contains tissue-specific cells. Epithelial stem cells, which are marked by leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5), have the potential for self-renewal and expansion as organoids. However, in the case of intestinal or...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hahn S,Kim MS,Choi SY,Jeong S,Jee J,Kim HK,Jeong SY,Shin H,Kim HS,Park JS,Yoo J

    更新日期:2019-01-08 00:00:00

  • Regulation of lipoprotein lipase secretion by mouse peritoneal macrophages.

    abstract::Resident mouse peritoneal macrophages in culture spontaneously secrete lipoprotein lipase. Secretion of lipoprotein lipase was 10-fold greater in thioglycollate-elicited and 6-fold greater in mineral oil-elicited macrophages. The increase in enzyme secretion was dependent on protein synthesis and glycosylation of the ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Goldberg DI,Khoo JC

    更新日期:1987-01-15 00:00:00

  • Self-assembly formed by a short DNA probe pair: Application for highly sensitive mRNA species detection without reverse transcription.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Usui M,Fujikawa T,Osawa M,Hakii C,Ikumi N,Nozaki T,Kitamura N,Hatta Y,Fujiwara S,Takei M

    更新日期:2015-11-27 00:00:00

  • Growth-rate-related and hydroxysterol-induced changes in membrane fluidity of cultured hepatoma cells: correlation with 3-hydroxy-3-methyl glutaryl CoA reductase activity.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Richert L,Castagna M,Beck JP,Rong S,Luu B,Ourisson G

    更新日期:1984-04-16 00:00:00

  • Down-regulation of miR-140-3p can alleviate neonatal repetitive pain in rats via inhibiting TGF-β3.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhang J,Yin J,Chen X,Mao X,Xu J,Cheng R,Wu J

    更新日期:2019-08-06 00:00:00

  • Triticone A: a novel bioactive lactam with potential as a molecular probe.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kenfield D,Strobel S,Sugawara F,Berglund D,Strobel G

    更新日期:1988-11-30 00:00:00

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Furukawa A,Furukawa K,Azuma T

    更新日期:2004-06-25 00:00:00

  • Nucleolar stress characterized by downregulation of nucleophosmin: a novel cause of neuronal degeneration.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Marquez-Lona EM,Tan Z,Schreiber SS

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Felberg J,Johnson P

    更新日期:2000-05-10 00:00:00

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Mathur V,Verma A,Maiti S,Chowdhury S

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Yilmaz A,Kliche S,Mayr-Beyrle U,Fellbrich G,Waltenberger J

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Qiao L,Paul P,Lee S,Qiao J,Wang Y,Chung DH

    更新日期:2013-05-31 00:00:00

  • Reduction of nitric oxide producing activity associated with in vitro aging in cultured human umbilical vein endothelial cell.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Sato I,Morita I,Kaji K,Ikeda M,Nagao M,Murota S

    更新日期:1993-09-15 00:00:00

  • The 26S proteasome assembly is regulated by a maturation-inducing hormone in starfish oocytes.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Sawada MT,Morinaga C,Izumi K,Sawada H

    更新日期:1999-01-19 00:00:00

  • Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Anguita J,Chalfant ML,Civan MM,Coca-Prados M

    更新日期:1995-03-08 00:00:00

  • Cathepsin Q, a novel lysosomal cysteine protease highly expressed in placenta.

    abstract::The complete nucleotide sequence of a novel cathepsin cDNA derived from rat placenta was determined and is termed cathepsin Q. The predicted protein of 343 amino acid is a member of the family C1A protease related to cathepsin L. Rat cathepsin Q and its mouse counterpart were found highly expressed in placenta, wherea...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Sol-Church K,Frenck J,Mason RW

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  • Regulation of sterol biosynthesis in sunflower by 24(R,S),25-epiminolanosterol, a novel C-24 methyl transferase inhibitor.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Nes WD,Janssen GG,Norton RA,Kalinowska M,Crumley FG,Tal B,Bergenstrahle A,Jonsson L

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  • Circular RNA hsa_circ_0000673 promotes hepatocellular carcinoma malignance by decreasing miR-767-3p targeting SET.

    abstract::The importance of circular RNAs (circRNAs) in human cancers has gradually been acknowledged. In hepatocellular carcinoma (HCC), several circRNAs have been reported to regulate tumor growth and metastasis. However, the role of hsa_circ_0000673 in HCC remains largely unknown. In this study, we found that hsa_circ_000067...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Jiang W,Wen D,Gong L,Wang Y,Liu Z,Yin F

    更新日期:2018-06-02 00:00:00

  • Loss of MURC/Cavin-4 induces JNK and MMP-9 activity enhancement in vascular smooth muscle cells and exacerbates abdominal aortic aneurysm.

    abstract::Abdominal aortic aneurysm (AAA) is relatively common in elderly patients with atherosclerosis. MURC (muscle-restricted coiled-coil protein)/Cavin-4 modulating the caveolae function of muscle cells is expressed in cardiomyocytes, skeletal muscle cells and smooth muscle cells. Here, we show a novel functional role of MU...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Miyagawa K,Ogata T,Ueyama T,Kasahara T,Nakanishi N,Naito D,Taniguchi T,Hamaoka T,Maruyama N,Nishi M,Kimura T,Yamada H,Aoki H,Matoba S

    更新日期:2017-06-03 00:00:00

  • Activation of muscarinic receptors stimulates the release of choline from brain slices.

    abstract::The effect of several agents known to interact with muscarinic acetylcholine receptors on the release of choline from slices of rat corpus striatum into the incubation medium has been investigated. The amount of released choline was increased if choline, acetylcholine, or oxotremorine had been added to the incubation ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Dolezal V,Tucek S

    更新日期:1984-05-16 00:00:00

  • Neurotrophic effect of Semaphorin 4D in PC12 cells.

    abstract::Semaphorins provide crucial attractive and repulsive cues involved in axon guidance during neural development. Out of them, Semaphorin 4D (Sema4D) is enriched in the nervous and immune tissues, and acts as proliferative and survival factors of peripheral lymphocytes in the immune system, but is poorly understood in th...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Fujioka S,Masuda K,Toguchi M,Ohoka Y,Sakai T,Furuyama T,Inagaki S

    更新日期:2003-02-07 00:00:00

  • The brain-type glucose transporter mRNA is specifically expressed at the blood-brain barrier.

    abstract::The brain-type glucose transporter (bGT) is assumed to be distributed among neurons and glial cells, but to be particularly enriched in brain microvascular endothelium, which makes up the blood-brain barrier (BBB) in vivo. However, in the course of the present studies it was found that the bGT is specifically expresse...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Boado RJ,Pardridge WM

    更新日期:1990-01-15 00:00:00

  • Purification and characterization of a new form of cytochrome P-450 (LM2b) from untreated male rabbit liver microsomes.

    abstract::A new form of cytochrome P-450 has been purified from untreated male rabbit liver microsomes. This form was designated P-450 LM2b on the basis of its electrophoretic mobility on SDS polyacrylamide gel, where it migrates as a polypeptide of apparent molecular weight of 50,250. This hemoprotein exhibits a maximum at 448...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Bonfils C,Larroque C,Maurel P

    更新日期:1986-02-13 00:00:00

  • Expression of rat interleukin-5 and generation of neutralizing antiserum: a comparative study of rat IL-5 produced in Escherichia coli and insect cells.

    abstract::A cDNA coding for rat IL-5 was obtained by RT-PCR from total spleen RNA. With the exception of a single a.a. replacement at position 85 (L-P), it is identical to the published sequence obtained by retroviral gene transfer. This cDNA was used to express biologically active recombinant IL-5 in E. coli and in insect cell...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Pierrot C,Cocude C,Cêtre C,Godin C,Lafitte S,Capron M,Khalife J

    更新日期:1998-12-30 00:00:00

  • Alpha 2-antiplasmin's carboxy-terminal lysine residue is a major site of interaction with plasmin.

    abstract::alpha 2-Antiplasmin (AP) inhibits plasmin in a two-step reaction in which AP reversibly binds to lysine-binding sites of plasmin and, then, more slowly complexes covalently with the enzyme's active site. Here, we show that the C-terminal lysine residue of AP has a key role in binding of the inhibitor to plasmin. A syn...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hortin GL,Gibson BL,Fok KF

    更新日期:1988-09-15 00:00:00

  • Expression and localization in spermatozoa of the mitochondrial porin isoform 2 in Drosophila melanogaster.

    abstract::Mitochondrial porins or VDACs (voltage-dependent anion-selective channels) are transmembrane pore-forming proteins. In eukaryotic genomes multiple genes coding for VDAC homologues have been discovered, but their function remains unknown. In Drosophila melanogaster three additional genes homologous to the gene porin ha...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Guarino F,Specchia V,Zapparoli G,Messina A,Aiello R,Bozzetti MP,De Pinto V

    更新日期:2006-08-04 00:00:00

  • Persistent BDNF exon I-IX mRNA expression following the withdrawal of neuronal activity in neurons.

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    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hara D,Miyashita T,Fukuchi M,Suzuki H,Azuma Y,Tabuchi A,Tsuda M

    更新日期:2009-12-18 00:00:00