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Genome-wide location analysis reveals an important overlap between the targets of the yeast transcriptional regulators Rds2 and Adr1.

Abstract：

:Upon glucose depletion, a massive reprogramming of gene expression occurs in the yeast Saccharomyces cerevisiae for the use of alternate carbon sources such as the nonfermentable compounds ethanol and glycerol. This process is mediated by the master kinase Snf1 that controls the activity of various targets including the transcriptional regulators Cat8, Sip4 and Adr1. We have recently identified Rds2 as an additional player in this pathway. Here, we have performed genome-wide location analysis of Rds2 in cells grown in the presence of glycerol. We show that Rds2 binds to promoters of genes involved in gluconeogenesis, the glyoxylate shunt, and the TCA cycle as well as some genes encoding mitochondrial components or some involved in the stress response. Interestingly, we also detected Rds2 at the promoters of SIP4, ADR1 and HAP4 which encodes the limiting subunit of the Hap2/3/4/5 complex, a regulator of respiration. Strikingly, we observed an important overlap between the targets of Rds2 and Adr1. Finally, we provide a model to account for the complex interplay among these transcriptional regulators.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Soontorngun N,Baramee S,Tangsombatvichit C,Thepnok P,Cheevadhanarak S,Robert F,Turcotte B

doi

10.1016/j.bbrc.2012.05.151

subject

Has Abstract

pub_date

2012-07-13 00:00:00

pages

632-7

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)01050-9

journal_volume

423

pub_type

杂志文章

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