当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Phenobarbital and some other liver tumor promoters stimulate DNA synthesis in cultured rat hepatocytes.

Phenobarbital and some other liver tumor promoters stimulate DNA synthesis in cultured rat hepatocytes.

Abstract：

:Hepatocytes isolated from normal adult rats were maintained at sub-confluent density in a defined medium in primary culture. In control cultures with added epidermal growth factor and low concentrations of dexamethasone, the rate of DNA synthesis was initially low but increased after about 30 hours in culture. Addition of the xenobiotic liver tumor promoters phenobarbital, alpha-hexachlorocyclohexane or p,p'-dichlorodiphenyltrichloroethane to cultures after cell attachment caused concentration-dependent stimulation of DNA synthesis measured after 2 days in culture. While dexamethasone (30 nM) alone had little effect on hepatocyte DNA synthesis, the stimulatory effects of the xenobiotics required the permissive presence of the steroid.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Edwards AM,Lucas CM

doi

10.1016/0006-291x(85)91776-0

subject

Has Abstract

pub_date

1985-08-30 00:00:00

pages

103-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)91776-0

journal_volume

131

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Transcriptional activation of EGFR by HOXB5 and its role in breast cancer cell invasion.

    abstract：:HOX genes are transcription factors that play important roles in body patterning and many cellular processes during embryonic, fetal, and adult development. Given their important function in normal tissues, it is reasonable to assume that abnormal expression of HOX genes in adults could lead to serious diseases such a...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.08.071

    authors： Lee JY,Kim JM,Jeong DS,Kim MH

    更新日期：2018-09-18 00:00:00

  • Protein synthesis inhibition induces proteasome assembly and function.

    abstract：:Protein synthesis and degradation balance have a crucial role in maintenance of cellular homeostasis and function. The ubiquitin-proteasome system is one of the major cellular proteolytic machineries responsible for the removal of normal, abnormal, denatured or in general damaged proteins. Proteasome is a multisubunit...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.04.114

    authors： Sakellari M,Chondrogianni N,Gonos ES

    更新日期：2019-06-18 00:00:00

  • Effect of interleukin 1 beta on transducing mechanisms in 235-1 clonal pituitary cells. Part I: Modulation of adenylate cyclase activity.

    abstract：:In the present study we evaluated the effect of interleukin 1-beta on adenylate cyclase activity in 235-1 pituitary cell line. The dose-response curve of interleukin 1 beta effect on adenylate cyclase activity showed a significant inhibition of basal enzyme activity at 1 pM concentration, while the inhibition of forsk...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)81252-x

    authors： Schettini G,Florio T,Meucci O,Scala G,Landolfi E,Grimaldi M

    更新日期：1988-09-30 00:00:00

  • BST2 inhibits infection of influenza A virus by promoting apoptosis of infected cells.

    abstract：:BST2 is an antiviral factor that inhibits the release of enveloped virus at the plasma membrane via an unusual topology in which its N-terminal is in the cytosol while its C-terminal is anchored by glycophosphatidylinositol (GPI). BST2-deficient cells showed substantially higher release of virions than wild type cells...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.12.110

    authors： Yi E,Oh J,Kang HR,Song MJ,Park SH

    更新日期：2019-02-05 00:00:00

  • Modulation of cyclic AMP accumulation in GH3 cells by a phorbol ester and thyroliberin.

    abstract：:4 beta phorbol-12, 13-dibutyrate (PDBu) stimulated cyclic AMP accumulation in GH3 pituitary tumour cells in the presence of isobutylmethylxanthine. This effect persisted after preincubation of cells with cholera or pertussis toxins. In contrast, vasoactive intestinal polypeptide (VIP)-stimulated cyclic AMP accumulatio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91976-x

    authors： Quilliam LA,Dobson PR,Brown BL

    更新日期：1985-06-28 00:00:00

  • A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins.

    abstract：:Tumor protein D52-like proteins (TPD52) are small coiled-coil motif bearing proteins that were first identified in breast cancer. TPD52 and related proteins have been implicated in cell proliferation, apoptosis, and vesicle trafficking. To date, three human TPD52 members had been identified, named hD52 (TPD52), hD53 (...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.03.208

    authors： Cao Q,Chen J,Zhu L,Liu Y,Zhou Z,Sha J,Wang S,Li J

    更新日期：2006-06-09 00:00:00

  • Brain-specific transcript variants of 5' and 3' ends of mouse VPS13A and VPS13C.

    abstract：:Mutations in vacuolar protein sorting 13A (VPS13A) gene are responsible for chorea-acanthocytosis (ChAc). We previously determined the full-length sequence and exon-intron structure of mouse VPS13A and generated a ChAc model mouse by using the gene targeting technique. In the process, we found diverse 5' and 3' transc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.12.122

    authors： Mizuno E,Nakamura M,Agemura A,Kusumoto A,Ichiba M,Kurano Y,Muroya S,Sano A

    更新日期：2007-02-23 00:00:00

  • Probing the catalytic mechanism of bovine pancreatic deoxyribonuclease I by chemical rescue.

    abstract：:Previous structural and mutational studies of bovine pancreatic deoxyribonuclease I (bpDNase I) have demonstrated that the active site His134 and His252 played critical roles in catalysis. In our present study, mutations of these two His residues to Gln, Ala or Gly reduced the DNase activity by a factor of four to fiv...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.11.078

    authors： Chen WJ,Lai PJ,Lai YS,Huang PT,Lin CC,Liao TH

    更新日期：2007-01-19 00:00:00

  • A new comprehensive method for detection of livestock-related pathogenic viruses using a target enrichment system.

    abstract：:We tested usefulness of a target enrichment system SureSelect, a comprehensive viral nucleic acid detection method, for rapid identification of viral pathogens in feces samples of cattle, pigs and goats. This system enriches nucleic acids of target viruses in clinical/field samples by using a library of biotinylated R...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.12.017

    authors： Oba M,Tsuchiaka S,Omatsu T,Katayama Y,Otomaru K,Hirata T,Aoki H,Murata Y,Makino S,Nagai M,Mizutani T

    更新日期：2018-01-08 00:00:00

  • Silica-induced generation of reactive oxygen species in Rat2 fibroblast: role in activation of mitogen-activated protein kinase.

    abstract：:Exposure to silica has been associated with progressive pulmonary inflammation and fibrosis. While the fibroblasts play an important role in the pathogenesis of silicosis, the direct interaction between silica and fibroblasts is poorly understood. We observed that silica particles stimulated intracellular ROS generati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1274

    authors： Cho YJ,Seo MS,Kim JK,Lim Y,Chae G,Ha KS,Lee KH

    更新日期：1999-09-07 00:00:00

  • Characterization of the BUD31 gene of Saccharomyces cerevisiae.

    abstract：:A number of genes have been identified in the fully sequenced genome of Saccharomyces cerevisiae that appear to be conserved throughout evolution and the function of which remains poorly understood. In this manuscript we describe the initial characterization of yeast BUD31 gene. cDNA sequences highly related to BUD31 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.05.228

    authors： Masciadri B,Areces LB,Carpinelli P,Foiani M,Draetta G,Fiore F

    更新日期：2004-08-06 00:00:00

  • Molecular basis of bird respiration: primary hemoglobin structure component from Tufted duck (Aythya fuligula, Anseriformes)--role of alpha99Arg in formation of a complex salt bridge network.

    abstract：:The primary structure of the major hemoglobin component, HbA (alpha(A)- and beta-chain), from Tufted duck (Aythya fuligula) is presented. The separation of the globin subunits was achieved by ion exchange chromatography on CM-cellulose in 8 M urea. The amino acid sequence was determined by automatic Edman degradation ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2002.6399

    authors： Abbasi A,Lutfullah G

    更新日期：2002-02-15 00:00:00

  • Cooperative binding of gamma-glutamyl substrate to human glutathione synthetase.

    abstract：:Human glutathione synthetase is responsible for catalyzing the final step in glutathione biosynthesis. It is a homodimer with a monomer subunit MW of 52 kDa. Kinetic analysis reveals a departure from linearity of the Lineweaver-Burk double reciprocal plot for the binding of gamma-glutamyl substrate, indicating coopera...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5961

    authors： Njalsson R,Norgren S,Larsson A,Huang CS,Anderson ME,Luo JL

    更新日期：2001-11-23 00:00:00

  • A putative tetrapeptide antagonist prevents beta-amyloid-induced long-term elevation of [Ca2+]i in rat astrocytes.

    abstract：:Comparative fluorimetric studies on the long-term (8-hour) action of beta[1-42]amyloid and its shorter fragments beta[1-40], beta[25-35] and beta[31-35] on the steady-state intracellular Ca2+ concentration in primary cultures of rat astroglial cells using the Ca2+-sensitive fluorescent probe Fura-2 AM revealed higher ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6806

    authors： Laskay G,Zarándi M,Varga J,Jost K,Fónagy A,Torday C,Latzkovits L,Penke B

    更新日期：1997-06-27 00:00:00

  • Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1.

    abstract：:AMP-activated protein kinase (AMPK) is a master metabolic regulator, and is an important target for drug development against diabetes, obesity, and other diseases. AMPK is a hetero-trimeric enzyme, with a catalytic (alpha) subunit, and two regulatory (beta and gamma) subunits. Here we report the crystal structure at 2...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.09.181

    authors： Rudolph MJ,Amodeo GA,Bai Y,Tong L

    更新日期：2005-12-02 00:00:00

  • Bidirectional regulation of mitochondrial gene expression during developmental neuroplasticity of visual cortex.

    abstract：:The first several months of life are a critical period for neuronal plasticity in the visual cortex, during which anatomical and physiological development depends upon visual experience. Rearing in darkness slows the time course of this critical period, such that at 5 weeks normal cats are more plastic than dark-reare...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5706

    authors： Yang C,Silver B,Ellis SR,Mower GD

    更新日期：2001-10-12 00:00:00

  • Mitochondrial malate dehydrogenase and its precursor have different conformations.

    abstract：:Antiserum prepared against the denatured form of mammalian malate dehydrogenase was found to immunoprecipitate the denatured but not the native form of the mature enzyme. In contrast, the antiserum immunoprecipitated the enzyme's precursor, synthesized in a rabbit reticulocyte lysate, either before or after denaturati...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80370-9

    authors： Chien SM,Freeman KB

    更新日期：1986-11-26 00:00:00

  • Isolation of wound healing/regeneration genes using restrictive fragment differential display-PCR in MRL/MPJ and C57BL/6 mice.

    abstract：:Wound healing in mammals can take several weeks to months and the process is always accompanied by scar formation. Wound healing mechanisms that mimic regeneration are not found in most mature mammalian tissues. However, the MRL/MPJ (MRL) mouse has the unique capacity to regenerate ear hole wound completely in less th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.02.143

    authors： Masinde G,Li X,Baylink DJ,Nguyen B,Mohan S

    更新日期：2005-04-29 00:00:00

  • Small-angle X-ray scattering study by synchrotron orbital radiation reveals that high molecular weight subunit of glutenin is a very anisotropic molecule.

    abstract：:Small-angle X-ray scattering of one high molecular weight (HMW) subunit of wheat glutenin was measured at protein concentration ranges from 1.0 to 10.0 mg/ml. The radius of gyration of whole particles, RO, in aq. 50% (v/v) 1-propanol and 0.1M acetic acid was 16.6 +/- 0.1nm and 22.8nm, respectively, and the correspondi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)90854-e

    authors： Matsushima N,Danno G,Sasaki N,Izumi Y

    更新日期：1992-07-31 00:00:00

  • The characterization of 5 histidine-serine mutants of human 5-lipoxygenase.

    abstract：:The physical and catalytic properties of 5 histidine-serine mutants of human 5-lipoxygenase (5-LO) have been characterized. The mutants HS363, HS391 and HS400 have activities, pH optima and stabilities similar to those of the wild type enzyme. The iron content of each of these mutants is 0.30-0.53 mol Fe/mol 5-LO whic...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81542-6

    authors： Percival MD,Ouellet M

    更新日期：1992-08-14 00:00:00

  • Nucleoside transport in activated macrophages.

    abstract：:The study of [3H]-uridine uptake by mouse peritoneal macrophages showed that this is an active, temperature- and protein synthesis-dependent phenomenon, which is early altered when are exposed to a variety of stimuli. Murine recombinant interferon-gamma, a stimulus able to activate macrophage and to induce the product...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)91663-x

    authors： Busolo F,Conventi L,Gatti C,Monti D,Troiano L,Franceschi C

    更新日期：1989-04-14 00:00:00

  • Suppression of Npr1, not Npr2 gene function induces hypertrophic growth in H9c2 cells in vitro.

    abstract：:Npr1 gene (coding for NPR-A) and Npr2 gene (coding for NPR-B) are identified as intrinsic anti-hypertrophic genes that opposes abnormal cardiac remodeling. However, the functional role of Npr1 and Npr2 genes during cardiac hypertrophic growth is not well understood. Hence, the present investigation was aimed to study ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.07.123

    authors： Manivasagam S,Vellaichamy E

    更新日期：2017-09-16 00:00:00

  • Attenuation of TGF-beta-induced apoptosis in primary cultures of hepatocytes by calpain inhibitors.

    abstract：:Apoptosis induced in primary cultures of rat hepatocytes by transforming growth factor beta 1 (TGF-beta 1) was greatly attenuated by inhibitors (5 microM) of calpain I and calpain II, respectively. Both inhibitors prevented the TGF-beta-elicited increase of nucleosomal DNA fragments and the occurrence of DNA-breaks in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.5777

    authors： Gressner AM,Lahme B,Roth S

    更新日期：1997-02-13 00:00:00

  • Potent antiviral effect of silver nanoparticles on SARS-CoV-2.

    abstract：:The pandemic of COVID-19 is spreading unchecked due to the lack of effective antiviral measures. Silver nanoparticles (AgNP) have been studied to possess antiviral properties and are presumed to inhibit SARS-CoV-2. Due to the need for an effective agent against SARS-CoV-2, we evaluated the antiviral effect of AgNPs. W...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.09.018

    authors： Jeremiah SS,Miyakawa K,Morita T,Yamaoka Y,Ryo A

    更新日期：2020-11-26 00:00:00

  • Reduced secretion and expression of gelatinase profile in Toxoplasma gondii-infected human monocytic cells.

    abstract：:The apicomplexan Toxoplasma gondii, an obligate intracellular parasite, can infect humans and a wide range of vertebrates. Following oral infection, the parasite invades tissues by crossing non-permissive biological barriers such as the placenta or the blood-brain barrier. But the molecular mechanisms underlying migra...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.05.089

    authors： Buache E,Garnotel R,Aubert D,Gillery P,Villena I

    更新日期：2007-07-27 00:00:00

  • Evidence for myosin-binding phosphatase in heart myofibrils.

    abstract：:Protein phosphatase was partially purified from myofibrils of bovine heart by sequential column chromatographies. The purified protein phosphatase was immunologically identified as a delta isoform of PP1 (PP1delta). The myosin-binding subunit (MBS) of myosin-binding phosphatase (MBP) in smooth muscle was co-purified w...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.7005

    authors： Nishio H,Ichikawa K,Hartshorne DJ

    更新日期：1997-07-30 00:00:00

  • A set of 14 DIP-SNP markers to detect unbalanced DNA mixtures.

    abstract：:Unbalanced DNA mixture is still a difficult problem for forensic practice. DIP-STRs are useful markers for detection of minor DNA but they are not widespread in the human genome and having long amplicons. In this study, we proposed a novel type of genetic marker, termed DIP-SNP. DIP-SNP refers to the combination of IN...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.02.109

    authors： Liu Z,Liu J,Wang J,Chen D,Liu Z,Shi J,Li Z,Li W,Zhang G,Du B

    更新日期：2018-03-04 00:00:00

  • Arsenic trioxide inhibits neuroblastoma growth in vivo and promotes apoptotic cell death in vitro.

    abstract：:Recent clinical studies have shown that inorganic arsenic trioxide (As(2)O(3)) at low concentrations induces complete remission with minimal toxicity in patients with refractory acute promyelocytic leukemia (APL). Preclinical studies suggest that As(2)O(3) induces apoptosis and possibly differentiation in APL cells. L...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3651

    authors： Ora I,Bondesson L,Jönsson C,Ljungberg J,Pörn-Ares I,Garwicz S,Pâhlman S

    更新日期：2000-10-14 00:00:00

  • The biogenesis of SARS-CoV-2 spike glycoprotein: multiple targets for host-directed antiviral therapy.

    abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19 (coronavirus disease-19), represents a far more serious threat to public health than SARS and MERS coronaviruses, due to its ability to spread more efficiently than its predecessors. Currently, there is no worldwide-approved ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.10.080

    authors： Santopolo S,Riccio A,Santoro MG

    更新日期：2020-11-28 00:00:00

  • Activation of plasminogen by Streptococcus mutans.

    abstract：:Streptococcus mutans, a member of the viridans streptococci, is the etiologic agent of dental caries and is also a causative agent of subacute infective endocarditis. The generation of proteolytic molecules, such as plasmin, may be important in the pathogenesis of endocarditis caused by S. mutans. In this study, we de...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.07.077

    authors： Jones MN,Holt RG

    更新日期：2004-09-10 00:00:00