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Expression and localization of regenerating gene I in a rat liver regeneration model.

Abstract：

:Regenerating gene (Reg) I has been identified as a regenerative/proliferative factor for pancreatic islet cells. We examined Reg I expression in the regenerating liver of a rat model that had been administered 2-acetylaminofluorene and treated with 70% partial hepatectomy (2-AAF/PH model), where hepatocyte and cholangiocyte proliferation was suppressed and the hepatic stem cells and/or hepatic progenitor cells were activated. In a detailed time course study of activation of hepatic stem cells in the 2-AAF/PH model, utilizing immunofluorescence staining with antibodies of Reg I and other cell-type-specific markers, we found that Reg I-expressing cells are present in the bile ductules and increased during regeneration. Reg I-expressing cells were colocalized with CK19, OV6, and AFP. These results demonstrate that Reg I is significantly upregulated in the liver of the 2-AAF/PH rat model, accompanied by the formation of bile ductules during liver regeneration.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wang J,Koyota S,Zhou X,Ueno Y,Ma L,Kawagoe M,Koizumi Y,Okamoto H,Sugiyama T

doi

10.1016/j.bbrc.2009.01.126

subject

Has Abstract

pub_date

2009-03-13 00:00:00

pages

472-7

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)00130-2

journal_volume

380

pub_type

杂志文章

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