Comparative analysis of mutants in the mycothiol biosynthesis pathway in Mycobacterium smegmatis.

abstract：:The highly reactive electrophile, methylglyoxal (MG), a break down product of carbohydrates, is a major environmental mutagen having potential genotoxic effects. Previous studies have suggested the reaction of MG with free amino groups of proteins forming advanced glycation end products (AGEs). This results in the gen...

journal_title：Biochemical and biophysical research communications

authors： Ahmad S,Moinuddin,Dixit K,Shahab U,Alam K,Ali A

更新日期：2011-04-15 00:00:00

abstract：:The vanilloid receptor type 1 (VR1) is a novel membrane receptor activated by heat or chemical ligands conveying information about chemosensitive and thermosensitive pain. We have overexpressed and purified wild type VR1 (wtVR1) as well as several mutant forms using the yeast strain Saccharomyces cerevisiae with the g...

journal_title：Biochemical and biophysical research communications

authors： Moiseenkova VY,Hellmich HL,Christensen BN

更新日期：2003-10-10 00:00:00

abstract：:Total kininogen in plasma of Freund's adjuvant treated rats increased 20-fold 7 days following the injection. Analysis of the kininogens demonstrated that increases in T-kininogen was the major reason for the rise in kininogen. High molecular weight and low molecular weight kininogens showed little or no change. The i...

journal_title：Biochemical and biophysical research communications

authors： Barlas A,Okamoto H,Greenbaum LM

更新日期：1985-05-31 00:00:00

abstract：:C-terminal binding protein 2 (CtBP2) is a transcriptional co-repressor involved in cell migration, apoptosis, and tumorization. Up-regulation of CtBP2 is implicated in various human cancers including breast cancers. In our present study, we found that the C-terminus of Hsc70-interacting protein (CHIP) regulated the st...

journal_title：Biochemical and biophysical research communications

authors： Lee JS,Yoo SJ

更新日期：2013-03-15 00:00:00

abstract：:Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system and is mediated by complement-dependent cytotoxicity (CDC) of NMO-specific immunoglobulin G (IgG) antibodies (NMO-IgG). Glycyrrhizic acid (GA) has numerous pharmacological effects including inhibition of the complement pa...

journal_title：Biochemical and biophysical research communications

authors： Kim JS,Cheon S,Kim SW,Kim B,Kim H,Park KD,Kim SM

更新日期：2016-09-16 00:00:00

abstract：:The important role of pyruvate kinase during malarial infection has prompted the cloning of a cDNA encoding Plasmodium falciparum pyruvate kinase (pfPyrK), using mRNA from intraerythrocytic-stage malaria parasites. The full-length cDNA encodes a protein with a computed molecular weight of 55.6 kDa and an isoelectric p...

journal_title：Biochemical and biophysical research communications

authors： Chan M,Sim TS

更新日期：2005-01-07 00:00:00

abstract：:Monoclonal antibodies against chick embryonic beta-galactoside-binding lectin were obtained. One of the monoclonal antibodies was ineffective in Western blotting and seemed to be unable to bind the SDS-denatured lectin. When the native lectin was dotted on a nitrocellulose filter and subjected to denaturation by treat...

journal_title：Biochemical and biophysical research communications

authors： Oda Y,Kasai K

更新日期：1984-09-28 00:00:00

abstract：:In this study, we assessed the profile of cell proliferation, Na,K-ATPase activity and apoptosis in primary cultures of proximal tubule cells. Freshly isolated proximal tubules exhibited apoptosis very early in culture: floated cells within 6 hr; attached tubule cells within 20 hr. The onset of apoptosis in either att...

journal_title：Biochemical and biophysical research communications

authors： Tang MJ,Cheng YR,Lin HH

更新日期：1996-01-26 00:00:00

abstract：:Protein markers induced by hormones are the necessary probes to study hormone regulation of gene expression. We have previously shown that ACTH was able to induce one of these markers in the cytosol of the rat adrenal: protein E (Dazord et al, Biochem. J., 176, 233-239, 1978). In this paper by using adrenal mRNA from ...

journal_title：Biochemical and biophysical research communications

authors： Langlois-Gallet D,Dazord A

更新日期：1984-03-30 00:00:00

abstract：:Adipose tissue is an active endocrine organ producing a variety of cytokines and chemokines, which may be involved in the deregulation of glucose and lipid homeostasis as well as in the inflammatory state observed in obesity. We have shown previously that differentiated human adipocytes secrete a variety of cytokines ...

journal_title：Biochemical and biophysical research communications

authors： Sell H,Dietze-Schroeder D,Eckardt K,Eckel J

更新日期：2006-05-12 00:00:00

abstract：:Tau plays important roles in the assembly and stabilization of the microtubule structure to facilitate axonal transport in mammalian brain. The intracellular tau aggregates to form paired helical filaments leading to neurodegenerative disorders, collectively called tauopathies. In our previous report, we established a...

journal_title：Biochemical and biophysical research communications

authors： Wu BK,Yuan RY,Chang YP,Lien HW,Chen TS,Chien HC,Tong TS,Tsai HP,Fang CL,Liao YF,Chang CC,Chen RP,Huang CJ

更新日期：2016-08-19 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT), a key process in the tumor metastatic cascade, is characterized by the loss of cell-cell junctions and cell polarity, as well as the acquisition of migratory and invasive properties. Snail is an EMT-inducer whose expression in several different epithelial cells, e.g., Madin...

journal_title：Biochemical and biophysical research communications

authors： Ozawa M,Kobayashi W

更新日期：2015-03-13 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) plays roles in cancer progression by degrading the extracellular matrix and basement membrane. Many growth factors including Transforming growth factor-beta1 (TGF-beta1) could induce MMP-9 expression. We demonstrated that TGF-beta1 induced MMP-9 mRNA and protein in human head and nec...

journal_title：Biochemical and biophysical research communications

authors： Sinpitaksakul SN,Pimkhaokham A,Sanchavanakit N,Pavasant P

更新日期：2008-07-11 00:00:00

abstract：:Calcium is found a strong stimulator of sulfite reduction from hydrogen. A coupling protein of molecular weight 65,000 can be isolated from Desulfovibrio gigas. It functions in a reconstituted electron transfer chain between hydrogenase and sulfite reductase. Its N-terminal sequence shows high homologies with calcium ...

journal_title：Biochemical and biophysical research communications

authors： Chen L,Liu MY,Le Gall J

更新日期：1991-10-15 00:00:00

abstract：:Porcine kidney betaine aldehyde dehydrogenase (EC 1.2.1.8) kinetic properties were determined at low substrate concentrations. The double-reciprocal plots of initial velocity versus substrate concentration are linear and intersect at the left of the 1/v axis and showed substrate inhibition with betaine aldehyde. Studi...

journal_title：Biochemical and biophysical research communications

authors： Figueroa-Soto CG,Valenzuela-Soto EM

更新日期：2000-03-16 00:00:00

abstract：:Terminal Schwann cells (TSCs) that cover motor neuron terminals are known to play important roles in maintaining neuromuscular junctions, as well as in the repair process after nerve injury. However, molecular characteristics of TSCs remain unknown, because of the difficulties in analyzing them due to their paucity. W...

journal_title：Biochemical and biophysical research communications

authors： Oda R,Yaoi T,Okajima S,Kobashi H,Kubo T,Fushiki S

更新日期：2003-09-05 00:00:00

abstract：:MutT-related proteins degrade 8-oxo-7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP), a mutagenic substrate for DNA synthesis, in the nucleotide pool, thereby preventing DNA replication errors. During a search of GenBank EST database, we found a new member of MutT-related protein, MTH2, which possesses the 23-amino...

journal_title：Biochemical and biophysical research communications

authors： Cai JP,Ishibashi T,Takagi Y,Hayakawa H,Sekiguchi M

更新日期：2003-06-13 00:00:00

abstract：:Tumor cell extravasation into the brain requires passage through the blood-brain barrier, which is a highly protected microvascular environment fortified with tight junction (TJ) proteins. TJ integrity can be regulated under physiological and pathophysiological conditions. There is evidence that exercise can modulate ...

journal_title：Biochemical and biophysical research communications

authors： Wolff G,Davidson SJ,Wrobel JK,Toborek M

更新日期：2015-08-07 00:00:00

abstract：:In this study, we demonstrate that the active site architecture of the human glutathione (GSH) S-transferase Pi (GSTP1-1) accounts for its enantioselectivity in the GSH conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9, 10-tetrahydrobenzo(a) pyrene (anti-BPDE), the ultimate carcinogen of benzo(a)pyrene. F...

journal_title：Biochemical and biophysical research communications

authors： Hu X,O'Donnell R,Srivastava SK,Xia H,Zimniak P,Nanduri B,Bleicher RJ,Awasthi S,Awasthi YC,Ji X,Singh SV

更新日期：1997-06-18 00:00:00

abstract：:Satellite cells are quiescent muscle stem cells that promote postnatal muscle growth and repair. When satellite cells are activated by myotrauma, they proliferate, migrate, differentiate, and ultimately fuse to existing myofibers. The remainder of these cells do not differentiate, but instead return to quiescence and ...

journal_title：Biochemical and biophysical research communications

authors： Nishimura T,Nozu K,Kishioka Y,Wakamatsu J,Hattori A

更新日期：2008-06-06 00:00:00

abstract：:One of the monocytic cell colony stimulating factors produced by thymic myoid cells, a 100 kDa factor, was purified by reversed phase HPLC and found to be homologous to the secreted form of proteoglycan 1 (biglycan) core protein. This biglycan associated colony stimulating factor did not carry an immunological motif o...

journal_title：Biochemical and biophysical research communications

authors： Kamo I,Kikuchi A,Nonaka I,Yamada E,Kondo J

更新日期：1993-09-15 00:00:00

abstract：:A polymerizable gel superaggregate has been formed from low concentrations (6 mM) of phospholipid mixtures of polymerizable 1,2-bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine and 1,2-bis(dinonoyl)-sn-glycero-3-phosphocholine. Transmission electron microscopy (TEM) revealed that the superaggregate structure con...

journal_title：Biochemical and biophysical research communications

authors： Markowitz MA,Singh A,Chang EL

更新日期：1994-08-30 00:00:00

abstract：:Pancreatic cancers are resistant to TNF-alpha-mediated apoptosis. Silencer of death domains (SODD) binds to TNF-alpha receptor TNFR-1, and prevents spontaneous self-association of death domains and inappropriate receptor signaling. In addition, overexpression of SODD suppresses TNF-alpha-induced cell death. In this re...

journal_title：Biochemical and biophysical research communications

authors： Ozawa F,Friess H,Zimmermann A,Kleeff J,Büchler MW

更新日期：2000-05-10 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ) peptide in the brain, which is produced by the proteolysis of β-amyloid precursor protein (APP). Recently, the mitochondrial transcription factor 4 (MTERF4), a member of the MTERF family, was implicated in regulating mitochondrial DNA transc...

journal_title：Biochemical and biophysical research communications

authors： Wang XL,Liu Q,Chen GJ,Li ML,Ding YH

更新日期：2017-01-22 00:00:00

abstract：:Oxidants and inflammatory mediators such as tumour necrosis factor-alpha (TNF-alpha) activate transcription factors such as NF-kappa B. Interleukin-8 (IL-8) is a ubiquitous inflammatory chemokine that mediates a multitude of inflammatory events in the lung. Ergothioneine is a naturally occurring thiol compound, which ...

journal_title：Biochemical and biophysical research communications

authors： Rahman I,Gilmour PS,Jimenez LA,Biswas SK,Antonicelli F,Aruoma OI

更新日期：2003-03-21 00:00:00

abstract：:A chemically synthesized 2,2,7-trimethylguanosine cap (TMG-cap) analogue was added to an in vitro pre-mRNA splicing system. A slight inhibition of the splicing was observed, but it was much less remarkable than that by a 7-methylguanosine cap analogue. This result does not favor a direct role of the TMG-cap structure ...

journal_title：Biochemical and biophysical research communications

authors： Tokumoto Y,Iwase R,Sekine M,Hata T,Ohshima Y

更新日期：1989-08-15 00:00:00

abstract：:Ribosome-inactivating proteins (RIPs) are N-glycosidases (EC3.2.2.22) that universally inactivate the ribosome, thereby inhibiting protein biosynthesis. In this study, a novel type I RIPs named SEBIN was identified in Sapium sebiferum. Nuclear acid depurine experiment showed that SEBIN had rRNA N-Glycosidase activity....

journal_title：Biochemical and biophysical research communications

authors： Wu Y,Mao Y,Jin S,Hou J,Du H,Yang M,Wu L

更新日期：2015-08-07 00:00:00

abstract：:Although mammary epithelial cells are known to synthesize and accumulate triacylglycerol (TAG) in order to produce milk lipid in the cytosol, lipid and energy metabolism is still not fully understood. In this study, we assessed the effects of long-chain fatty acid (LCFA) on the accumulation of cytosolic TAG and uncoup...

journal_title：Biochemical and biophysical research communications

authors： Yonezawa T,Sanosaka M,Haga S,Kobayashi Y,Katoh K,Obara Y

更新日期：2008-10-17 00:00:00

abstract：:Dysregulation and aggregation of the peptide hormone IAPP (islet amyloid polypeptide, a.k.a. amylin) into soluble oligomers that appear to be cell-toxic is a known aspect of diabetes mellitus (DM) Type 2 pathology. IAPP aggregation is influenced by several factors including interactions with metal ions such as Cu(II)....

journal_title：Biochemical and biophysical research communications

authors： Dong X,Svantesson T,Sholts SB,Wallin C,Jarvet J,Gräslund A,Wärmländer SKTS

更新日期：2019-03-19 00:00:00

abstract：:We have identified four surface 83 kDa proteins of pI values 6.3, 6.4, 6.5 and 6.6 in T. cruzi trypomastigotes which specifically bind to rat heart myoblasts. These proteins were purified by isoelectric focusing and anion-exchange chromatography in an FPLC system. These 83 kDa proteins inhibit the attachment of trypom...

journal_title：Biochemical and biophysical research communications

authors： Villalta F,Lima MF,Zhou L

更新日期：1990-10-30 00:00:00