Phosphorylation of calcineurin: effect on calmodulin binding.

abstract：:Lung cancer is the leading cause of cancer deaths. Epidermal growth factor receptor (EGFR) kinase domain mutations are a common cause of non-small cell lung cancers (NSCLCs), a major subtype of lung cancers. Patients harboring most of these mutations respond well to the anti-EGFR tyrosine kinase inhibitors (TKIs) gefi...

journal_title：Biochemical and biophysical research communications

authors： Zhao P,Yao MY,Zhu SJ,Chen JY,Yun CH

更新日期：2018-07-20 00:00:00

abstract：:We have screened a lambda gt11 cDNA library from chicken gizzard muscle with polyclonal antiserum to avian synemin. Immunopositive clones were characterized and sequenced. Computer searches identified primarily intermediate filament (IF) proteins as being homologous to the synemin clones. Synemin's sequence contained ...

journal_title：Biochemical and biophysical research communications

authors： Becker B,Bellin RM,Sernett SW,Huiatt TW,Robson RM

更新日期：1995-08-24 00:00:00

abstract：:Gastrointestinal (GI) anthrax, caused by the bacterial infection of Bacillus anthracis, posts a significant bioterrorism threat by its relatively high mortality rate in humans. Different from inhalational anthrax by the route of infection, accumulating evidence indicates the bypass of vegetative bacteria across GI epi...

journal_title：Biochemical and biophysical research communications

authors： Bishop BL,Lodolce JP,Kolodziej LE,Boone DL,Tang WJ

更新日期：2010-04-02 00:00:00

abstract：:We have isolated a cDNA encoding human epidermal transglutaminase, a key enzyme of terminal differentiation of keratinocytes. A cDNA library from cultured human keratinocytes was screened by a PCR-amplified partial cDNA fragment of the enzyme with oligonucleotide primers based on the homology of the transglutaminase f...

journal_title：Biochemical and biophysical research communications

authors： Yamanishi K,Liew FM,Konishi K,Yasuno H,Doi H,Hirano J,Fukushima S

更新日期：1991-03-29 00:00:00

abstract：:Osteoblasts/stromal cells support the formation of osteoclast-like cells (OCL) from osteoclast progenitor cells via expressing a membrane-associated protein, osteoclast differentiation factor (ODF), in the presence of osteotropic factors, whereas the cells secrete a substantial amount of osteoclastogenesis inhibitory ...

journal_title：Biochemical and biophysical research communications

authors： Nagai M,Sato N

更新日期：1999-04-21 00:00:00

abstract：:We have found that atrial natriuretic factor (ANF) has a profound effect on testicular cells in altering intracellular cyclic nucleotide levels as well as progesterone secretion. Using clonal cultured Leydig tumor cells we found that 1 X 10(-8)M ANF caused a two thousand-fold elevation in the accumulation of cellular ...

journal_title：Biochemical and biophysical research communications

authors： Pandey KN,Kovacs WJ,Inagami T

更新日期：1985-12-17 00:00:00

abstract：:The recently deorphanized niacin receptor subtypes NIACR1 (GPR109A) and NIACR2 (GPR109B) play an essential role in the regulation of metabolic processes and immune reactions. Both receptors belong to the G-protein-coupled receptor (GPCR) family, whose members have traditionally been treated as monomeric entities, but ...

journal_title：Biochemical and biophysical research communications

authors： Mandrika I,Petrovska R,Klovins J

更新日期：2010-04-30 00:00:00

abstract：:Kinetic studies on the cyclization of 2,3(S)-oxido and 2,3(S):22(S),23-dioxido[14C]squalene catalyzed by liver oxidosqualene-lanosterol cyclase revealed a specificity (in terms of V/Km) of the enzyme for the diepoxide. The specificity ratio was dependent on the enzyme preparation, i.e. purified or microsomal, and was ...

journal_title：Biochemical and biophysical research communications

authors： Boutaud O,Dolis D,Schuber F

更新日期：1992-10-30 00:00:00

abstract：:We determined the cDNA sequence for neurocalcin, a novel calcium-binding protein in bovine brain. This clone (pCalN) has 582 nucleotides in the open reading frame including the termination codon TGA, 11 nucleotides of the 5' leader and 1251 nucleotides of the 3' noncoding region. The deduced amino acid sequence reveal...

journal_title：Biochemical and biophysical research communications

authors： Okazaki K,Watanabe M,Ando Y,Hagiwara M,Terasawa M,Hidaka H

更新日期：1992-05-29 00:00:00

abstract：:Leucine-rich alpha(2)-glycoprotein (LRG) is a plasma protein in which leucine-rich repeats (LRRs) were first discovered. Although the physiological function of LRG is not known, increases in the serum level of LRG have been reported in various diseases. In this study, we found that LRG was induced by recombinant human...

journal_title：Biochemical and biophysical research communications

authors： Shirai R,Hirano F,Ohkura N,Ikeda K,Inoue S

更新日期：2009-05-15 00:00:00

abstract：:The function of His159 in the enolase mechanism is disputed. Recently, Vinarov and Nowak (Biochemistry (1999) 38, 12138-12149) prepared the H159A mutant of yeast enolase 1 and expressed this in Escherichia coli. They reported minimal (ca. 0.01% of the native value) activity, though the protein appeared to be correctly...

journal_title：Biochemical and biophysical research communications

authors： Brewer JM,Holland MJ,Lebioda L

更新日期：2000-10-05 00:00:00

abstract：:We have identified two neuropeptides (F1 and F2) from suboesophageal and thoracic ganglia of Locusta migratoria, which we isolated earlier based on their immunological similarity to arginine vasopressin. The more abundant and hydrophilic factor, F1, has sequence Cys-Leu-Ile-Thr-Asn-Cys-Pro-Arg-Gly-NH2, but its biologi...

journal_title：Biochemical and biophysical research communications

authors： Proux JP,Miller CA,Li JP,Carney RL,Girardie A,Delaage M,Schooley DA

更新日期：1987-11-30 00:00:00

abstract：:Chronic subcutaneous infusion of small doses (0.1 microgram/h) of ovine corticotropin-releasing factor (oCRF) into rats for 8 days resulted in differential alteration of proopiomelanocortin (POMC) mRNA levels in the individual pituitary lobes: In the anterior lobe POMC mRNA levels, quantitated by hybridisation using a...

journal_title：Biochemical and biophysical research communications

authors： Höllt V,Haarmann I

更新日期：1984-10-30 00:00:00

abstract：:Cytochrome P450 3A4, the most abundant P450 form in human liver, exhibits a very broad substrate specificity and is of great importance for drug metabolism. The interindividual difference in the hepatic expression of CYP3A4 is considerable. In order to investigate possible genetic factor(s) causing this variation, the...

journal_title：Biochemical and biophysical research communications

authors： Westlind A,Löfberg L,Tindberg N,Andersson TB,Ingelman-Sundberg M

更新日期：1999-05-27 00:00:00

abstract：:[3H]cyclo(His-Pro) bound with high affinity (59 nM) to a single class of sites in rat liver plasma membranes, without significant tracer degradation during equilibration for 60 min at 0 degrees C. Binding was specific and saturable (3.9 pmol/mg protein), and were increased by the addition of K+, Mg++ and Na+ at optima...

journal_title：Biochemical and biophysical research communications

authors： Mori M,Yamada M,Yamaguchi M,Suzuki M,Ohshima K,Kobayashi I,Kobayashi S

更新日期：1986-01-14 00:00:00

abstract：:Periplasmic proteins of Gram-negative bacteria like Escherichia coli are subjected to immediate affect of environmental fluctuation that may unfold proteins, due to the permeability of the outer membrane to small molecules. They are thus supposedly protected by certain molecular chaperones. Nevertheless, no homologues...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Fu X,Shen J,Zhang H,Hong W,Chang Z

更新日期：2004-04-09 00:00:00

abstract：:Fractionation of rat uterine cells incubated at 22 degrees C with 0.2 nM [3H]-estradiol-17 beta (E2 beta) was performed to analyze the subcellular distribution of internalized hormone. The postnuclear supernatant of homogenates was resolved in Percoll density gradients into six major fractions defined by enzyme marker...

journal_title：Biochemical and biophysical research communications

authors： Pietras RJ,Szego CM

更新日期：1984-08-30 00:00:00

abstract：:Plant reproduction is an extremely important phenomenon, as it is strongly associated with plant genetics and early development. Additionally, foundations of the reproductive system have direct implications on plant breeding and agriculture. Investigation of the functions of male and female gametophytes is critical si...

journal_title：Biochemical and biophysical research communications

authors： Liu X,Wu X,Adhikari PB,Zhu S,Kinoshita Y,Berger F,Higashiyama T,Kasahara RD

更新日期：2020-01-22 00:00:00

abstract：:Tumor invasion of host tissues and trophoblastic penetration of the endometrium share common biological features. Both processes involve the invasion of basement membranes, an event that is initiated by adhesion of cancer or trophoblast cells to basement membrane components and particularly to laminin. Adhesion to thi...

journal_title：Biochemical and biophysical research communications

authors： van den Brûle FA,Price J,Sobel ME,Lambotte R,Castronovo V

更新日期：1994-05-30 00:00:00

abstract：:By using a 45Ca2+ overlay technique, we found two calcium-binding proteins (CaBPs) abundant in bovine amniotic fluid, and named them CAAF1 (calcium-binding protein in amniotic fluid-1) and CAAF2. CAAF1 was identified as a novel S100 protein produced by fetal epidermal keratinocytes, squamous epithelial cells and polym...

journal_title：Biochemical and biophysical research communications

authors： Hitomi J,Maruyama K,Kikuchi Y,Nagasaki K,Yamaguchi K

更新日期：1996-11-21 00:00:00

abstract：:The fungal AAL-toxin triggers programmed cell death (PCD) through perturbations of sphingolipid metabolism in AAL-toxin-sensitive plants. While Arabidopsis is relatively insensitive to the toxin, the loh2 mutant exhibits increased susceptibility to AAL-toxin due to the knockout of a gene involved in sphingolipid metab...

journal_title：Biochemical and biophysical research communications

authors： Gechev TS,Ferwerda MA,Mehterov N,Laloi C,Qureshi MK,Hille J

更新日期：2008-10-31 00:00:00

abstract：:Neurotensin (NT), a gastrointestinal (GI) hormone, binds its receptor (NTR) to stimulate proliferation of normal and neoplastic GI tissues; the molecular mechanisms remain largely undefined. Mitogen-activated protein kinases (MAPKs) are a family of intracellular kinases that transmit mitogenic signals by translocating...

journal_title：Biochemical and biophysical research communications

authors： Ehlers RA,Zhang Y,Hellmich MR,Evers BM

更新日期：2000-03-24 00:00:00

abstract：:A chemical inhibitor library of 84 compounds was screened to investigate the signaling pathway(s) leading to activation of Nrf2 in response to nitric oxide (NO). We identified the protein kinase C delta (PKCdelta) inhibitor rottlerin as the only compound that reduced NO-induced ARE-luciferase reporter activity and dim...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Hung AC,Ng PY,Nakayama K,Hu Y,Li B,Porter AG,Dhakshinamoorthy S

更新日期：2009-09-04 00:00:00

abstract：:Sensory transduction in the cochlea depends on regulated ion secretion and absorption. Results of whole-organ experiments suggested that Reissner's membrane may play a role in the control of luminal Cl(-). We tested for the presence of Cl(-) transport pathways in isolated mouse Reissner's membrane using whole-cell pat...

journal_title：Biochemical and biophysical research communications

authors： Kim KX,Marcus DC

更新日期：2010-04-02 00:00:00

abstract：:The aim of the present study was to accomplish de novo generation of reconstituted human skin with enriched hair follicles. Dermal papillae (DP) are known to play a crucial organizing role in hair follicle induction. However, generation of enriched human hair follicles using cultured DP cells has not been accomplished...

journal_title：Biochemical and biophysical research communications

authors： Yoshida Y,Soma T,Matsuzaki T,Kishimoto J

更新日期：2019-08-27 00:00:00

abstract：:Studies examining the relationship between cellular sortilin and VLDL-B100 secretion demonstrate inconsistent results. Current studies explore the possibility that discrepancies may be related to insulin sensitivity. McArdle RH7777 cells (McA cells) cultured under serum enriched conditions lose sensitivity to insulin....

journal_title：Biochemical and biophysical research communications

authors： Sparks RP,Guida WC,Sowden MP,Jenkins JL,Starr ML,Fratti RA,Sparks CE,Sparks JD

更新日期：2016-09-16 00:00:00

abstract：:Adenylate cyclase in homogenates of guinea pig ventricles was inhibited by the stable adenosine analogs N6-phenylisopropyladenosine (PIA) and 5(1)-N-ethylcarboxamidoadenosine (NECA). Inhibition required GTP and was enhanced by sodium ion. The maximum inhibition observed was 35.1 +/- 1.1%, the EC50 (95% confidence limi...

journal_title：Biochemical and biophysical research communications

authors： Leung E,Johnston CI,Woodcock EA

更新日期：1983-01-14 00:00:00

abstract：:Recent studies provide evidence that Sox4 is involved in regulating apoptosis as well as tumorigenesis of various human cancers; however, its role in the apoptotic machinery is not fully understood. Here we describe that the central domain containing glycine-rich region in Sox4, named CD, is a pivotal pro-apoptotic do...

journal_title：Biochemical and biophysical research communications

authors： Hur EH,Hur W,Choi JY,Kim IK,Kim HY,Yoon SK,Rhim H

更新日期：2004-12-03 00:00:00

abstract：:The decomposition of peroxynitrite in the presence of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) generated 5,5-dimethylpyrrolidone-(2)-oxy-(1) (DMPOX) without formation of DMPO/OH. Formate enhanced the peroxynitrite decomposition but did not generate any detectable amount of formate-derived free radicals. Glutathione, cy...

journal_title：Biochemical and biophysical research communications

authors： Shi X,Lenhart A,Mao Y

更新日期：1994-09-30 00:00:00

abstract：:The phosphatidylinositol-3-kinase (PI3K)/AKT axis and the Nuclear Factor kappa B (NFκB) pathway play critical roles in macrophage survival. In cells other than macrophages proper operation of those two pathways requires Ca²(+) influx into the cell, but if that is the case in macrophages remains unexplored. In the pres...

journal_title：Biochemical and biophysical research communications

authors： Tano JY,Vazquez G

更新日期：2011-04-08 00:00:00