A pungent ingredient of mustard, allylisothiocyanate, inhibits (H+ + K+)-ATPase.

abstract：:Designed peptides that would selectively interact with lipopolysaccharide (LPS) or endotoxin and fold into specific conformations could serve as important scaffolds toward the development of antisepsis compounds. Here, we describe solution structure of a designed amphipathic peptide, H(2)N-YVKLWRMIKFIR-CONH(2) (YW12D)...

journal_title：Biochemical and biophysical research communications

authors： Bhunia A,Chua GL,Domadia PN,Warshakoon H,Cromer JR,David SA,Bhattacharjya S

更新日期：2008-05-09 00:00:00

abstract：:The chemokine receptor CCR5 is constitutively associated with the T cell co-receptor CD4 in plasma cell membranes. The CD4-CCR5 complex exhibits distinct binding properties for macrophage inflammatory protein 1beta (MIP-1beta) and enhanced G-protein signaling as compared with those of CCR5 alone. Here we report that r...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Staudinger R

更新日期：2003-08-08 00:00:00

abstract：:Tauroursodeoxycholic acid (TUDCA) is known to prevent apoptosis through the Bax pathway and to promote neovascularization by enhancing the mobilization of stem cells, their differentiation. This study was performed to investigate the effect of TUDCA on erythropoiesis in hematopoietic stem cells (HSCs). Since erythropo...

journal_title：Biochemical and biophysical research communications

authors： Hong SH,Yoon KJ,Lim KH,Um YJ,Cho JG,Jo YJ,Park SG

更新日期：2016-09-30 00:00:00

abstract：:In this paper, the circadian pattern of Clock and genes mediated by the Clock was investigated in peripheral lymphocytes of rats. Circadian rhythms of Clock are found under the regimes of constant darkness (DD) and 12-h light-12-h dark (LD12:12h), with the peak phase at CT7 and ZT21, respectively. Ten differential cDN...

journal_title：Biochemical and biophysical research communications

authors： Du YZ,Fan SJ,Meng QH,Wang GQ,Tong J

更新日期：2005-11-04 00:00:00

abstract：:Activation of the receptor activator of nuclear factor-κB (RANK) by its ligand (RANKL) is involved in both solid and hematological malignancies, including multiple myeloma, acute myeloid leukemia and B-cell leukemia. Although RANKL expression has been described in normal T cells, a potential role in T-cell leukemia re...

journal_title：Biochemical and biophysical research communications

authors： Fernandes MT,Caroço LS,Pacheco-Leyva I,Dos Santos NR

更新日期：2019-03-05 00:00:00

abstract：:Centromere protein F (CENPF) is an essential nuclear protein associated with the centromere-kinetochore complex and plays a critical role in chromosome segregation during mitosis. Up-regulation of CENPF expression has previously been detected in several solid tumors. In this study, we aim to study the expression and f...

journal_title：Biochemical and biophysical research communications

authors： Dai Y,Liu L,Zeng T,Zhu YH,Li J,Chen L,Li Y,Yuan YF,Ma S,Guan XY

更新日期：2013-07-12 00:00:00

abstract：:Serotype conversion (O-antigen glucosylation) in Shigella flexneri is mediated by temperate bacteriophages, which encode a three-gene cluster that contains gtrA, gtrB, and gtr([type]). Sequence analysis has revealed that gtrA and gtrB are conserved and readily interchangeable between serotypes. The gtr([type]) is uniq...

journal_title：Biochemical and biophysical research communications

authors： Korres H,Mavris M,Morona R,Manning PA,Verma NK

更新日期：2005-03-25 00:00:00

abstract：:Although a majority of regulatory peptides elaborated by neuroendocrine cells are small, i.e., less than 50-60 residues, no low-molecular-weight, bone-derived mitogenic peptides have been described. We have size-fractionated extracts of neonatal mouse calvaria, a rapidly forming bone, and assayed for osteoblast prolif...

journal_title：Biochemical and biophysical research communications

authors： Birnbaum RS,Andress DL

更新日期：1990-11-30 00:00:00

abstract：:Arctigenin (ARC), a phenylpropanoid dibenzylbutyrolactone lignan derived from Arctium lappa L, has been reported to protect against cerebral ischemia injury in rats, but the underlying mechanism is unclear. In this study, we investigated whether ARC ameliorated ischemic stroke by inhibiting NLRP3 inflammasome-derived ...

journal_title：Biochemical and biophysical research communications

authors： Zhang S,Jiang L,Che F,Lu Y,Xie Z,Wang H

更新日期：2017-11-04 00:00:00

abstract：:Agmatine, a putative endogenous ligand of imidazoline receptors, suppresses cardiovascular function by inhibiting peripheral sympathetic tone. However, the molecular identity of imidazoline receptor subtypes and its cellular mechanism underlying the agmatine-induced sympathetic suppression remains unknown. Meanwhile, ...

journal_title：Biochemical and biophysical research communications

authors： Kim YH,Jeong JH,Ahn DS,Chung S

更新日期：2016-08-26 00:00:00

abstract：:Kidney anion exchanger 1 (kAE1) mediates chloride (Cl⁻) and bicarbonate (HCO₃⁻) exchange at the basolateral membrane of kidney α-intercalated cells. Impaired trafficking of kAE1 leads to defect of the Cl⁻/HCO₃⁻ exchange at the basolateral membrane and failure of proton (H+) secretion at the apical membrane, causing a ...

journal_title：Biochemical and biophysical research communications

authors： Sawasdee N,Junking M,Ngaojanlar P,Sukomon N,Ungsupravate D,Limjindaporn T,Akkarapatumwong V,Noisakran S,Yenchitsomanus PT

更新日期：2010-10-08 00:00:00

abstract：:Oxygen free radicals have been implicated in the pathogenesis of ischemic cell injuries. These free radicals are normally scavenged by antioxidant enzymes. Adenosine is normally released during ischemia and protects against ischemic injuries by interacting with adenosine receptors (ARs). The mechanism underlying its c...

journal_title：Biochemical and biophysical research communications

authors： Maggirwar SB,Dhanraj DN,Somani SM,Ramkumar V

更新日期：1994-06-15 00:00:00

abstract：:Expression of bone-associated proteins and osteoblastic transcription factor Runx2 in arterial cells has been implicated in the development of vascular calcification. However, the signaling upstream of the Runx2-mediated activation of osteoblastic program in vascular smooth muscle cells (VSMC) is poorly understood. We...

journal_title：Biochemical and biophysical research communications

authors： Nakahara T,Sato H,Shimizu T,Tanaka T,Matsui H,Kawai-Kowase K,Sato M,Iso T,Arai M,Kurabayashi M

更新日期：2010-04-02 00:00:00

abstract：:Four IgE-binding epitopes have been characterized that cover a large area (40%) of the molecular surface of lipid transfer protein allergens of Rosaceae (apple, peach, apricot, and plum). They mainly correspond to electropositively charged regions protruding on the molecular surface of the modeled apple (Mal d 3), apr...

journal_title：Biochemical and biophysical research communications

authors： Borges JP,Barre A,Culerrier R,Granier C,Didier A,Rougé P

更新日期：2008-01-25 00:00:00

abstract：:The activation of chloroplast fructose-1,6-bisphosphatase by fructose-1,6-bisphosphate, Ca2+, DTT and chloroplast thioredoxin-f is prevented by either spermidine or spermine; on the contrary, other amino compounds do not replace polyamines in this reversible effect. On the other hand, neither spermidine nor spermine m...

journal_title：Biochemical and biophysical research communications

authors： Corley E,Wolosiuk RA,Hertig CM

更新日期：1983-09-15 00:00:00

abstract：:Catabolite inactivation of fructose 1,6-bisphosphatase and cytoplasmic malate dehydrogenase was studied using the protease-deficient and vacuole-defective yeast strain pep4-3. The catabolite inactivation of fructose 1,6-bisphosphatase in pep4-3 was found to have a normal first inactivation step but with a defective se...

journal_title：Biochemical and biophysical research communications

authors： Funaguma T,Toyoda Y,Sy J

更新日期：1985-07-16 00:00:00

abstract：:Resveratrol (trans-3,5,4'-trihydroxystilbene), a polyphenolic compound found largely in the skins of red grapes, has been used as a nutritional supplement or an investigational new drug for prevention of cardiovascular diseases. Previous reports showed that resveratrol had a protective effect against oxidative agent-i...

journal_title：Biochemical and biophysical research communications

authors： Leong CW,Wong CH,Lao SC,Leong EC,Lao IF,Law PT,Fung KP,Tsang KS,Waye MM,Tsui SK,Wang YT,Lee SM

更新日期：2007-08-17 00:00:00

abstract：:Plants use specialized root outgrowths, termed root hairs, to enhance acquisition of nutrients and water, help secure anchorage, and facilitate interactions with soil microbiome. One of the major regulators of this process is GLABRA2 (GL2), a transcriptional repressor of root hair differentiation. However, regulation ...

journal_title：Biochemical and biophysical research communications

authors： Wu R,Citovsky V

更新日期：2017-07-01 00:00:00

abstract：:Enhancers are essential for long range chromatin opening and the activation of V(D)J recombination at the antigen receptor loci. The murine immunoglobulin lambda light chain locus is a duplicated locus and, using a bacterial artificial chromosome spanning the 3' half of the locus to generate transgenic mice, we have i...

journal_title：Biochemical and biophysical research communications

authors： Haque SF,Bevington SL,Boyes J

更新日期：2013-11-15 00:00:00

abstract：:Protein degradation is an essential quality control and regulatory function in organisms ranging from bacteria to eukaryotes. In bacteria, this process is initiated by ATP-dependent proteases which digest proteins to short peptides that are subsequently hydrolyzed to smaller fragments and free amino acids. While the e...

journal_title：Biochemical and biophysical research communications

authors： Jain R,Chan MK

更新日期：2007-08-03 00:00:00

abstract：:Platelets are an important place for the storage of angiogenic factors, such as vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF). The present study aims to investigate the interaction between BDNF-TrkB pathway and platelet activation during tumor development. In an orthotopic hepa...

journal_title：Biochemical and biophysical research communications

authors： Yang ZF,Ho DW,Lau CK,Tam KH,Lam CT,Poon RT,Fan ST

更新日期：2006-08-04 00:00:00

abstract：:Genomic imprinting is an epigenetic phenomenon by which a subset of genes is asymmetrically expressed in a parent-of-origin manner. However, little is known regarding the epigenetic behaviors of imprinted genes during human development. Here, we show dynamic epigenetic changes in imprinted genes in hESCs during in vit...

journal_title：Biochemical and biophysical research communications

authors： Park SW,Kim J,Park JL,Ko JY,Im I,Do HS,Kim H,Tran NT,Lee SH,Kim YS,Cho YS,Lee DR,Han YM

更新日期：2014-04-04 00:00:00

abstract：:In mammalian epidermis, alpha6beta4 integrin is expressed exclusively on the basal layer localized to the hemidesmosomes, where it interacts extracellularly with the laminin-5 ligand. During differentiation, loss of alpha6beta4 is associated with keratinocyte detachment from the basement membrane and upward migration....

journal_title：Biochemical and biophysical research communications

authors： Alt A,Gartsbein M,Ohba M,Kuroki T,Tennenbaum T

更新日期：2004-01-30 00:00:00

abstract：:Cav1.2 (alpha1C) and Cav1.3 (alpha1D) L-type Ca channels are co-expressed in the heart. To date, there are no pharmacological or biophysical tools to separate alpha1D from alpha1C Ca currents (I(Ca-L)) in cardiomyocytes. Here, we established a physiological model to study alpha1D I(Ca-L) in native myocytes using RNA i...

journal_title：Biochemical and biophysical research communications

authors： Karnabi E,Qu Y,Mancarella S,Yue Y,Wadgaonkar R,Boutjdir M

更新日期：2009-07-10 00:00:00

abstract：:The genomes of several vertebrates contain two genes encoding proteins highly similar to threonine synthase (TS), even though the biosynthesis of l-threonine (l-Thr) is not known to occur in these animals. We report a bioinformatic analysis of the two TS-like genes, the recombinant expression of one murine TS homolog ...

journal_title：Biochemical and biophysical research communications

authors： Donini S,Percudani R,Credali A,Montanini B,Sartori A,Peracchi A

更新日期：2006-12-01 00:00:00

abstract：:Betulin, a natural product isolated from the bark of the birch trees, exhibits multiple anticancer effects. Activation of mTOR signaling pathway has been found in numerous cancers, including renal cell carcinoma (RCC). Here, we attempted to study whether mTOR signaling was essential for betulin to treat RCC. Based on ...

journal_title：Biochemical and biophysical research communications

authors： Cheng W,Ji S,Zhang H,Han Z,Liu Q,Wang J,Ping H

更新日期：2017-01-22 00:00:00

abstract：:Tissue transglutaminase (TGase 2) has been reported to have multiple functions in addition to its function as a biological adhesive. To identify its roles, we investigated the effects of TGase 2 on gelatinase activity. The MMP-9 activity of certain cell lines was significantly inhibited with retinoic acid treatment, a...

journal_title：Biochemical and biophysical research communications

authors： Ahn JS,Kim MK,Hahn JH,Park JH,Park KH,Cho BR,Park SB,Kim DJ

更新日期：2008-11-28 00:00:00

abstract：:Interest in lipoamino acids as endogenous modulators of G-protein coupled receptors has escalated due to their involvement in a variety of physiologic processes. In particular, a role for these amino acid conjugates has emerged in the endocannabinoid system. The study presented herein investigated the effects of N-ara...

journal_title：Biochemical and biophysical research communications

authors： Console-Bram L,Ciuciu SM,Zhao P,Zipkin RE,Brailoiu E,Abood ME

更新日期：2017-09-02 00:00:00

abstract：:Slo3 channels (mSlo3) primarily mediate mouse sperm K(+) currents and are essential for the capacitation-associated hyperpolarization (CAH). Whether Slo3 and/or Slo1, two Slo family K(+) channels are functionally expressed in human sperm is controversial. Our recent pharmacological studies of the human sperm CAH sugge...

journal_title：Biochemical and biophysical research communications

authors： Sánchez-Carranza O,Torres-Rodríguez P,Darszon A,Treviño CL,López-González I

更新日期：2015-10-23 00:00:00

abstract：:A clone of vincristine resistant murine erythroleukemia cells V3.17[44], characterized by high sensitivity to terminal erythroid differentiation induced by hexamethylene bisacetamide, secretes into the extracellular medium a protein factor which partially reduces the latent period before commitment and accelerates the...

journal_title：Biochemical and biophysical research communications

authors： Sparatore B,Patrone M,Salamino F,Passalacqua M,Melloni E,Pontremoli S

更新日期：1990-11-30 00:00:00