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NF-κB-dependent RANKL expression in a mouse model of immature T-cell leukemia.

Abstract：

:Activation of the receptor activator of nuclear factor-κB (RANK) by its ligand (RANKL) is involved in both solid and hematological malignancies, including multiple myeloma, acute myeloid leukemia and B-cell leukemia. Although RANKL expression has been described in normal T cells, a potential role in T-cell leukemia remains undefined. Here, we used a model of immature T-cell leukemia/lymphoma, the TEL-JAK2 transgenic mice, to assess RANKL expression in leukemic cells and its regulatory mechanisms. We found that Rankl mRNA was significantly overexpressed in leukemic T cells when compared to wild-type thymocytes, their nonmalignant counterparts. Moreover, Rankl mRNA and RANKL surface expression in leukemic cells was induced by T-cell receptor (TCR) signaling activation, dependently on the NF-κB signaling pathway. These results indicate that TCR-activated leukemic T cells express high levels of RANKL and are potential inducers of RANK signaling in microenvironmental cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Fernandes MT,Caroço LS,Pacheco-Leyva I,Dos Santos NR

doi

10.1016/j.bbrc.2019.01.089

subject

Has Abstract

pub_date

2019-03-05 00:00:00

pages

272-277

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(19)30115-9

journal_volume

510

pub_type

杂志文章

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