Cyclic adenosine 3',5'-monophosphate, a second messenger in interleukin-1 mediated K562 cytostasis.

abstract：:The effects of heparin (180 micrograms/ml) on steady state mRNA levels for fibronectin, thrombospondin, actin and collagen types I and III were investigated in human umbilical artery smooth muscle cells. Heparin caused a 120% increase in thrombospondin mRNA levels and a 60% and 180% increase in the mRNA levels of proc...

journal_title：Biochemical and biophysical research communications

authors： Lyons-Giordano B,Brinker JM,Kefalides NA

更新日期：1989-08-15 00:00:00

abstract：:Elafin, a human skin derived inhibitor of human leukocyte elastase, was tested for inhibitory activity against proteinase 3, an elastin degrading proteinase of neutrophils. The inhibitory activity of elafin was compared with antileukoprotease and eglin C. Elafin proved to be a potent inhibitor of elastin-FITC degradat...

journal_title：Biochemical and biophysical research communications

authors： Wiedow O,Lüademann J,Utecht B

更新日期：1991-01-15 00:00:00

abstract：:Baicalin (BA) has been shown with anti-HIV-1 activity. Zinc is a nutrient element. The anti-HIV-1 activity of zinc complex of baicalin (BA-Zn) in vitro was studied and compared with the anti-HIV-1 activities between BA and BA-Zn in the present study. Our results suggested that BA-Zn has lower cytotoxicity and higher a...

journal_title：Biochemical and biophysical research communications

authors： Wang Q,Wang YT,Pu SP,Zheng YT

更新日期：2004-11-12 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPAR gamma) belongs to a nuclear receptor super family that functions as a master regulator of adipocyte differentiation. PPAR gamma binds its DNA response element together with a partner, retinoid X receptor (RXR), in fat cells. Five RXR ligands (HX600, HX630, DA022, ...

journal_title：Biochemical and biophysical research communications

authors： Sato M,Yajima Y,Kawashima S,Tanaka K,Kagechika H

更新日期：2001-01-26 00:00:00

abstract：:The brown planthopper, Nilaparvata lugens (N. lugens, Hemiptera: Delphacidae), and the green rice leafhopper, Nephotettix cincticeps (N. cincticeps, Hemiptera: Cicadellidae), two sap-sucking feeders, have caused many destructive agricultural disasters in East Asia, as they can bring diseases like 'hopper burn' and tra...

journal_title：Biochemical and biophysical research communications

authors： Qian N,Zheng P,Wang Y,Pan S,Li Y,Zhang C,Chen J,Teng J

更新日期：2016-02-19 00:00:00

abstract：:Ku70 is a protein that finds itself at the heart of several important cellular processes. It is essential to the non-homologous end joining pathway as a part of the DNA-end binding complex, required for proper maintenance of telomeres and contributes to DNA damage recognition and regulation of apoptosis. Forces that r...

journal_title：Biochemical and biophysical research communications

authors： Yurchenko V,Xue Z,Gama V,Matsuyama S,Sadofsky MJ

更新日期：2008-02-01 00:00:00

abstract：:We have previously reported that intraplatelet "cyclic AMP jumps" produced with newly synthesized photoactivatable cyclic AMP analogue, inhibited washed rat platelet aggregation and serotonin release as induced by thrombin. Using the same approach on human platelets, thrombin-induced platelet aggregation was dose-depe...

journal_title：Biochemical and biophysical research communications

authors： Blache D,Ciavatti M,Ponsin G,Nargeot J

更新日期：1987-07-15 00:00:00

abstract：:Genes of the IL-1 family encode three different peptides, IL-1alpha, IL-1beta, and IL-1Ra, respectively. IL-1 operates through IL-1RI, and is involved in airway inflammation in asthmatic subjects, whereas IL-1Ra appears to be a specific competitive inhibitor of IL-1. All genes are on chromosome 2q12-21 where genomewid...

journal_title：Biochemical and biophysical research communications

authors： Mao XQ,Kawai M,Yamashita T,Enomoto T,Dake Y,Sasaki S,Kataoka Y,Fukuzumi T,Endo K,Sano H,Aoki T,Kurimoto F,Adra CN,Shirakawa T,Hopkin JM

更新日期：2000-09-24 00:00:00

abstract：:Genomic DNA analysis revealed that the coding region of the rat histamine H3 receptor comprises three exons interrupted by two introns of approximately 1 kb each. Several H3 receptor mRNA variants were identified by PCR and cDNA cloning and sequencing. Four variants generated by pseudo-intron retention/deletion at the...

journal_title：Biochemical and biophysical research communications

authors： Morisset S,Sasse A,Gbahou F,Héron A,Ligneau X,Tardivel-Lacombe J,Schwartz JC,Arrang JM

更新日期：2001-01-12 00:00:00

abstract：:The disease diabetes mellitus arises as a consequence of a failure of the beta-cells in the islets of Langerhans of the pancreas to produce insulin in the amounts required to meet the needs of the body. Whole pancreas or islet transplants in patients with severe diabetes effectively restore insulin production. A lack ...

journal_title：Biochemical and biophysical research communications

authors： Lechner A,Leech CA,Abraham EJ,Nolan AL,Habener JF

更新日期：2002-05-03 00:00:00

abstract：:Hepatic stellate cells (HSCs) are major players in liver fibrogenesis. Accumulating evidence shows that suppression of autophagy plays an important role in the development and progression of liver disease. Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to yield phosphatidic acid (PA) an...

journal_title：Biochemical and biophysical research communications

authors： Seo HY,Jang BK,Jung YA,Lee EJ,Kim HS,Jeon JH,Kim JG,Lee IK,Kim MK,Park KG

更新日期：2014-06-20 00:00:00

abstract：:We developed a typing assay for HIV-1 using subtype specific peptides corresponding to the five major subtypes of HIV-1 (A to E). In eight patients serologically subtyped as A (n = 1), B (n = 3), C (n = 3) and E (n = 1) phyllogenetic analysis of sequenced V3 domain DNA completely correlated to the peptide serotyping. ...

journal_title：Biochemical and biophysical research communications

authors： Sherefa K,Sönnerborg A,Steinbergs J,Sällberg M

更新日期：1994-12-30 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) induced the inhibition of glioma cell migration. Here, we characterized the signaling mechanisms involved in the inhibitory action by S1P. In human GNS-3314 glioblastoma cells, the S1P-induced inhibition of cell migration was associated with activation of RhoA and suppression of Rac1. The...

journal_title：Biochemical and biophysical research communications

authors： Malchinkhuu E,Sato K,Maehama T,Mogi C,Tomura H,Ishiuchi S,Yoshimoto Y,Kurose H,Okajima F

更新日期：2008-02-22 00:00:00

abstract：:A gene library of Anaerocellum thermophilum Z-1320 was constructed in Escherichia coli using plasmid pUC18. Clones were selected by screening for hydrolysis of CMC, MU-Cel, lichenan and xylan. Recombinant clones expressing two beta-1,4-glucanases and two different xylanases were obtained. Both beta-1,4-glucanases were...

journal_title：Biochemical and biophysical research communications

authors： Bolshakova EV,Ponomariev AA,Novikov AA,Svetlichnyi VA,Velikodvorskaya GA

更新日期：1994-07-29 00:00:00

abstract：:Linoleic acid, an omega-6 unsaturated fatty acid, stimulated growth of the MDA-MB-231 and MCF-7 human breast cancer cell lines in culture. Responses of the estrogen-independent MDA-MB-231 cells both in serum-free medium and with 1% fetal bovine serum added were positively correlated with linoleic acid concentration ov...

journal_title：Biochemical and biophysical research communications

authors： Rose DP,Connolly JM

更新日期：1989-10-16 00:00:00

abstract：:7,8-Dihydrobiopterin is not an intermediate in the de novo biosynthesis of tetrahydrobiopterin, the cofactor required for aromatic amino acid hydroxylations. However, N-acetyl-serotonin inhibition of sepiapterin reductase, an enzyme whose previously only known function was the reduction of sepiapterin to 7,8-dihydrobi...

journal_title：Biochemical and biophysical research communications

authors： Milstien S,Kaufman S

更新日期：1983-09-30 00:00:00

abstract：:While recent insights indicate that the transcription factor Krüppel-like factor 4 (KLF4) is indispensable for vascular homeostasis, its exact role in proliferation and angiogenesis and how it functions remain unresolved. Thus, the aim of the present study was to evaluate the role of KLF4 in the proliferations of endo...

journal_title：Biochemical and biophysical research communications

authors： Zheng X,Li A,Zhao L,Zhou T,Shen Q,Cui Q,Qin X

更新日期：2013-08-09 00:00:00

abstract：:We have previously demonstrated that antibodies to the growth-associated protein, GAP-43, introduced intracellularly using a lipid carrier inhibited neurite outgrowth in NB2a/d1 neuroblastoma cells, and that culturing of these cells on adhesive substrates such as laminin or poly-L-lysine overcame this restriction. The...

journal_title：Biochemical and biophysical research communications

authors： Shea TB

更新日期：1994-08-30 00:00:00

abstract：:In order to develop improved synthetic gene transfer vectors, we have synthesized bifunctional peptides composed of a DNA binding peptide (P2) and ligand peptides selected by the phage display technique on tracheal epithelial cells. We have evaluated the capacity of these peptides to enhance the gene transfer efficien...

journal_title：Biochemical and biophysical research communications

authors： Vaysse L,Guillaume C,Burgelin I,Gorry P,Férec C,Arveiler B

更新日期：2002-02-08 00:00:00

abstract：:Murine interferon-alpha 1 and murine interferon-alpha 4 share 80% of their amino acids, yet the proteins differ considerably in their ability to protect mouse or hamster cells against viral infection. With the aim of localizing areas within these proteins which influence the biological response we have constructed hyb...

journal_title：Biochemical and biophysical research communications

authors： Zwarthoff EC,Gennissen A,Bosveld IJ,Trapman J,van Heuvel M

更新日期：1987-08-31 00:00:00

abstract：:It has been shown that the protein serine/threonine phosphatase type 2A alpha catalytic subunit (PP2A alpha) has a mutation consisting of a glycine substitution for cysteine at 269 in the okadaic acid resistant variant of CHO cells, and that the mutant protein is resistant to okadaic acid (Shima, H. et al. Proc. Natl....

journal_title：Biochemical and biophysical research communications

authors： Kaneko S,Shima H,Amagasa T,Takagi M,Sugimura T,Nagao M

更新日期：1995-09-14 00:00:00

abstract：:Estrogen is the primary sex hormone responsible for the development and modulation of the female reproductive system in all vertebrates including avian species. The actions of estrogen are mediated by the estrogen receptor, which could be modulated by the selective estrogen receptor modulator tamoxifen (TAM). In this ...

journal_title：Biochemical and biophysical research communications

authors： Mao Y,Wu X,An L,Li X,Li Z,Zhu G

更新日期：2018-02-19 00:00:00

abstract：:As a step towards the elucidation of the role played by nuclear polyphosphoinositides, we have investigated the effect of exogenous calcium free inositol (1,4,5)-trisphosphate on the in vitro phosphorylation of proteins in nuclei prepared from Swiss 3T3 cells treated with bombesin and insulin-like growth factor I. Whe...

journal_title：Biochemical and biophysical research communications

authors： Martelli AM,Gilmour RS,Manzoli FA,Cocco L

更新日期：1990-11-30 00:00:00

abstract：:The control of cellular adhesion to extracellular matrix proteins is poorly understood. In the present analyses, we set out to test the hypothesis that high galectin-3 concentration on the cell surface downregulates cellular adhesion to the extracellular matrix proteins. Various tumor cell lines were briefly incubated...

journal_title：Biochemical and biophysical research communications

authors： Ochieng J,Leite-Browning ML,Warfield P

更新日期：1998-05-29 00:00:00

abstract：:Integrins are a family of cell surface adhesion molecules which mediate cell adhesion and initiate signaling pathways that regulate cell spreading, migration, differentiation, and proliferation. TGF-beta is a multifunctional factor that induces a wide variety of cellular processes. In this study, we show that, TGF-bet...

journal_title：Biochemical and biophysical research communications

authors： Cai T,Lei QY,Wang LY,Zha XL

更新日期：2000-08-02 00:00:00

abstract：:Retinoic acid (RA) is described as an inhibitor of prostate cancer cell growth. We utilized reverse transcription-polymerase chain reaction (RT-PCR) to analyze expression of different isoforms of fibroblast growth factor 8 (FGF8) in response to RA. Results in the prostate cancer cell line LNCaP show that whereas overa...

journal_title：Biochemical and biophysical research communications

authors： Brondani V,Hamy F

更新日期：2000-05-27 00:00:00

abstract：:A phosphate buffer containing a mixture of glucose oxidase, acrylic acid derivatives, N,N'-1,2 dihydroxy-ethylene-bis(acrylamide), N,N'-(methylene)-bisacrylamide and surface-modified silica was radically polymerized with (NH4)2S2O8. The polymer formed a thin layer around the silica beads. After sieving of these polyme...

journal_title：Biochemical and biophysical research communications

authors： Burow M,Minoura N

更新日期：1996-10-14 00:00:00

abstract：OBJECTIVE:Foam cell formation in the arterial wall plays a key role in the development of atherosclerosis. Recent studies showed that Urotensin II (U II) is involved in the pathogenesis of atherosclerosis. Here we examined the effects of human U II on ATP-binding cassette transporter A1 (ABCA1) expression and the under...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Wu JF,Tang YY,Zhang M,Li Y,Chen K,Zeng MY,Yao F,Xie W,Zheng XL,Zeng GF,Tang CK

更新日期：2014-10-03 00:00:00

abstract：:Lipoprotein lipase (LPL) is present in cells involved in development of atherosclerosis (endothelial cells, smooth muscle cells, and macrophages). A direct involvement of LPL in atherogenesis has been suggested. Previously we used the surface plasmon resonance technique to study the interaction of lipoproteins with su...

journal_title：Biochemical and biophysical research communications

authors： Makoveichuk E,Lookene A,Olivecrona G

更新日期：1998-11-27 00:00:00

abstract：:Polycystin-1 (PC1) is a membrane protein expressed in tubular epithelia of developing kidneys and in other ductal structures. Recent studies indicate this protein to be putatively important in regulating intracellular Ca(2+) levels in various cell types, but little evidence exists for kidney epithelial cells. Here we ...

journal_title：Biochemical and biophysical research communications

authors： Aguiari G,Campanella M,Manzati E,Pinton P,Banzi M,Moretti S,Piva R,Rizzuto R,del Senno L

更新日期：2003-02-14 00:00:00