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Breast cancer subtypes express distinct receptor repertoires for tumor-associated macrophage derived cytokines.

Abstract：

:Infiltration of the tumor microenvironment by macrophages is associated with poor outcomes in breast cancer and other solid tumors, however the identity and roles of many of the soluble factors these macrophages produce remains to be elucidated in detail. In addition to producing angiogenic factors (e.g. VEGF), proteases (e.g. MMP9) and immunomodulatory factors (e.g. IL10) which, by modifying the local microenvironment, likely contribute to progression in the majority of solid tumors, we have evaluated the extent to which macrophage cytokines may differentially affect distinct breast cancer subtypes. We identified 23 cytokines produced in a culture model of human tumor-associated macrophages and report that basal and luminal breast cancer cell lines express different repertoires of receptors for these cytokines. These data suggest that tumor-associated macrophages make specific contributions to different breast cancer subtypes and that understanding the importance of these interactions will be crucial to developing subtype-specific therapies targeting the macrophage component of the breast tumor microenvironment.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Levano KS,Jung EH,Kenny PA

doi

10.1016/j.bbrc.2011.06.102

subject

Has Abstract

pub_date

2011-07-22 00:00:00

pages

107-10

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(11)01082-5

journal_volume

411

pub_type

杂志文章

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