Abstract:
:The target cell tropism of enveloped viruses is regulated by interactions between viral proteins and cellular receptors determining susceptibility at a host cell, tissue or species level. However, a number of additional cell-surface moieties can also bind viral envelope glycoproteins and could act as capture receptors, serving as attachment factors to concentrate virus particles on the cell surface, or to disseminate the virus infection to target organs or susceptible cells within the host. Here, we used Junín virus (JUNV) or JUNV glycoprotein complex (GPC)-pseudotyped particles to study their ability to be internalized by the human C-type lectins hDC- or hL-SIGN. Our results provide evidence that hDC- and hL-SIGN can mediate the entry of Junín virus into cells, and may play an important role in virus infection and dissemination in the host.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Martinez MG,Bialecki MA,Belouzard S,Cordo SM,Candurra NA,Whittaker GRdoi
10.1016/j.bbrc.2013.10.106subject
Has Abstractpub_date
2013-11-22 00:00:00pages
612-617issue
3eissn
0006-291Xissn
1090-2104pii
S0006-291X(13)01787-7journal_volume
441pub_type
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