Abstract:
:The mRNA coding for thyroglobulin in cattle homozygous for an autosomal recessive defect of thyroglobulin synthesis was investigated using a recombinant plasmid containing bovine mRNA coding sequence. Total RNA preparations from goiter contained one third of the thyroglobulin mRNA sequences found in normal thyroid tissue. This mRNA was not translated into thyroglobulin by Xenopus oocytes. Northern transfer analysis revealed both a normal sized and a smaller thyroglobulin mRNA in the goiter.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Ricketts MH,Vandenplas S,van der Walt M,van Jaarsveld PP,Bester AJ,Boyd CDdoi
10.1016/0006-291x(85)90597-2subject
Has Abstractpub_date
1985-01-16 00:00:00pages
240-6issue
1eissn
0006-291Xissn
1090-2104pii
0006-291X(85)90597-2journal_volume
126pub_type
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journal_title:Biochemical and biophysical research communications
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