Synthesis and characterization of a d(ApG) platinated nonanucleotide duplex.

abstract：:We have recently shown that optimal growth temperature (T(opt)) is one of the factors that influence genomic GC in prokaryotes. Our results have been disputed by Marashi and Ghalanbor, who claim that the correlations we show are not "robust" because the elimination of some points (arbitrarily chosen) leads, in some fa...

journal_title：Biochemical and biophysical research communications

authors： Musto H,Naya H,Zavala A,Romero H,Alvarez-Valin F,Bernardi G

更新日期：2005-05-06 00:00:00

abstract：:After screening the data base of the Berkeley Drosophila Genome Project with a sequence coding for the transmembrane region of a G protein-coupled receptor, we found that Drosophila might contain a gene coding for a receptor that is structurally related to the Gonadotropin-Releasing Hormone (GnRH) receptors from verte...

journal_title：Biochemical and biophysical research communications

authors： Hauser F,Søndergaard L,Grimmelikhuijzen CJ

更新日期：1998-08-28 00:00:00

abstract：:Pseudouridine in yeast 5S RNA was modified with 4-bromomethyl-7-methoxy-coumarin(BMC). Temperature dependence of fluorescence intensity was measured at various concentrations of Mg2+ and K+ cations. Hyperchromicity was also measured. At 100mM KCl and 10mM Mg2+, fluorescence intensity decreased with temperature as free...

journal_title：Biochemical and biophysical research communications

authors： Nagamatsu K,Miyazawa Y

更新日期：1983-07-18 00:00:00

abstract：:The DiFi and HT-29 human colorectal cancer cell lines were characterized and compared with respect to binding properties of alpha adrenoceptors present on the cell surface. Both cell lines possessed alpha-1 and alpha-2 adrenoceptors of high affinity; however, DiFi cells were rich in alpha-1 adrenoceptors, whereas HT-2...

journal_title：Biochemical and biophysical research communications

authors： Agrawal DK,Wildrick DM,Boman BM

更新日期：1992-05-29 00:00:00

abstract：:Permeability alteration of microvascular endothelia is a factor in the plasma leakage produced by dengue virus (DV) infection, and beta3 integrin plays central roles in maintaining capillary integrity and regulating vascular permeability. In this study, interaction between beta3 integrin and DV serotype 2 (DV2) was in...

journal_title：Biochemical and biophysical research communications

authors： Zhang JL,Wang JL,Gao N,Chen ZT,Tian YP,An J

更新日期：2007-05-11 00:00:00

abstract：:The primary amino acid sequence of the carboxyl-terminal portion of the alpha 3 chain of chicken type VI collagen (K-VI) presents a 58-residue motif with a high degree of homology with members of the Kunitz serine-proteinase inhibitors family. This module was cloned, expressed in E. coli, purified and compared to the ...

journal_title：Biochemical and biophysical research communications

authors： Bearz A,Tolazzi G,Leonardi A,Pucillo C,Tell G,Colombatti A,Formisano S

更新日期：1995-10-24 00:00:00

abstract：:The stabilized carbonium ion salt, tropylium tetrafluoroborate, was oxidized to tropone (cycloheptatrienone) by rabbit liver aldehyde oxidase but not by the closely related molybdenum hydroxylase, xanthine oxidase. The tropylium cation is an aromatic hydrocarbon which lacks the aldehyde, imine, or iminium functional g...

journal_title：Biochemical and biophysical research communications

authors： Banks RB,Barnett SD

更新日期：1986-10-30 00:00:00

abstract：:We investigated the effect of ziprasidone, a widely used treatment for schizophrenia, on voltage-dependent K+ (Kv) channels of coronary arterial smooth muscle cells using the patch-clamp technique. Ziprasidone dose-dependently inhibited Kv channels with an IC50 value of 0.39 ± 0.06 μM and a Hill coefficient of 0.62 ± ...

journal_title：Biochemical and biophysical research communications

authors： An JR,Seo MS,Jung HS,Heo R,Kang M,Ha KS,Park H,Park WS

更新日期：2020-08-20 00:00:00

abstract：:Mental status changes are usually associated with septic shock. However, the molecular mechanisms underlying physiological changes of the central nervous system (CNS) remain speculative. We have investigated the expression of interleukin (IL)-12, one of the central cytokines in inflammatory and immune responses, in th...

journal_title：Biochemical and biophysical research communications

authors： Park JH,Shin SH

更新日期：1996-07-16 00:00:00

abstract：:Fibroblast growth factor (FGF)-23 was identified as a causative factor of tumor-induced osteomalacia and also as a responsible gene for autosomal dominant hypophosphatemic rickets. To clarify the pathophysiological roles of FGF-23 in these diseases, we generated its transgenic mice. The transgenic mice expressing huma...

journal_title：Biochemical and biophysical research communications

authors： Shimada T,Urakawa I,Yamazaki Y,Hasegawa H,Hino R,Yoneya T,Takeuchi Y,Fujita T,Fukumoto S,Yamashita T

更新日期：2004-02-06 00:00:00

abstract：:Sphingosine 1-phosphate (S1P) has recently been described to induce antimycobacterial activity. The present study analyses the role played by S1P in antigen presentation of monocytes and in the next activation of Mycobacterium tuberculosis (MTB)-specific CD4+ T cell response. Results reported herein show that S1P stim...

journal_title：Biochemical and biophysical research communications

authors： Santucci MB,Greco E,De Spirito M,Arcovito G,De Angelis G,Cauda R,Fraziano M

更新日期：2007-09-28 00:00:00

abstract：:It has been well established that estrogen is involved in the pathophysiology of breast cancer. Estrogen receptor (ER) alpha appears to promote the proliferation of cancer tissues, while ERbeta can protect against the mitogenic effect of estrogen in breast tissue. The expression status of ERalpha and ERbeta may greatl...

journal_title：Biochemical and biophysical research communications

authors： Koyama S,Wada-Hiraike O,Nakagawa S,Tanikawa M,Hiraike H,Miyamoto Y,Sone K,Oda K,Fukuhara H,Nakagawa K,Kato S,Yano T,Taketani Y

更新日期：2010-02-12 00:00:00

abstract：:A fusion protein comprising the DNA-binding region of the glucocorticoid receptor and the catalytic domain of poly(ADP-ribose) polymerase was constructed. This chimeric protein was expressed both in E. coli and in eukaryotic cells and was recognized by antibodies to both polymerase and the glucocorticoid receptor. Sim...

journal_title：Biochemical and biophysical research communications

authors： Rosenthal D,Hong T,Cherney B,Zhang S,Shima T,Danielsen M,Smulson M

更新日期：1994-07-29 00:00:00

abstract：:Manganese (Mn) is required in various human physiological processes. Excessive Mn exposure causes manganism, a progressive neurodegenerative disorder similar to idiopathic Parkinson's disease (IPD). However, the detailed mechanism of Mn-induced neurotoxicity is not yet fully understood. MicroRNAs (miRNAs) play importa...

journal_title：Biochemical and biophysical research communications

authors： He R,Xie X,Lv L,Huang Y,Xia X,Chen X,Zhang L

更新日期：2017-04-29 00:00:00

abstract：:The synthetic-peptide strategy was used to generate antibodies raised against calcium-dependent lectins of vertebrates. We demonstrate that a synthetic peptide predicted from the amino acid sequence of the carbohydrate recognition domain can induce blocking antibodies which would react with, or in close vicinity of, t...

journal_title：Biochemical and biophysical research communications

authors： Blanck O,Thibault V,Granier C,Van Rietschoten J,Courageot J,Miquelis R

更新日期：1990-06-29 00:00:00

abstract：:A number of genes have been identified in the fully sequenced genome of Saccharomyces cerevisiae that appear to be conserved throughout evolution and the function of which remains poorly understood. In this manuscript we describe the initial characterization of yeast BUD31 gene. cDNA sequences highly related to BUD31 ...

journal_title：Biochemical and biophysical research communications

authors： Masciadri B,Areces LB,Carpinelli P,Foiani M,Draetta G,Fiore F

更新日期：2004-08-06 00:00:00

abstract：:The human Ube2J2 enzyme functions in the ubiquitination of proteins at the ER. Here we demonstrate that it, and a second ubiquitin conjugating (Ubc) enzyme Ube2G2, are unstable, and incubation of transfected cells with proteasome inhibitors increased steady-state protein levels. For Ube2J2, pharmacological induction o...

journal_title：Biochemical and biophysical research communications

authors： Lam SY,Murphy C,Foley LA,Ross SA,Wang TC,Fleming JV

更新日期：2014-08-29 00:00:00

abstract：:Hepatitis C virus (HCV) is dependent on NS2-3 autocleavage and NS5A phosphorylation for its life cycle. We demonstrate that NS5A, when released from the NS2-5 polyprotein of the BK virus strain, is phosphorylated as two distinct forms, pp56 and pp58. Deletion analysis indicates that the appearance of pp58 requires NS2...

journal_title：Biochemical and biophysical research communications

authors： Liu Q,Bhat RA,Prince AM,Zhang P

更新日期：1999-01-27 00:00:00

abstract：:Nerve growth factor (NGF) elicits Akt translocation into the nucleus, where it phosphorylates nuclear targets. Here, we describe that Akt phosphorylation can promote the nuclear translocation of Akt and is necessary for its nuclear retention. Overexpression of Akt-K179A, T308A, S473A-mutant failed to show either nucle...

journal_title：Biochemical and biophysical research communications

authors： Xuan Nguyen TL,Choi JW,Lee SB,Ye K,Woo SD,Lee KH,Ahn JY

更新日期：2006-10-20 00:00:00

abstract：:N-Acetylglucosaminyltransferase I (GlcNAcT-I, EC 2.4.1.101) is the enzyme which initiates the formation of complex N-linked glycans in eukaryotes by transforming GlcNAc to the oligo-mannosyl acceptor Man(5)GlcNAc(2)-Asn. The enzymatic activity and the structure that is synthesised by this enzyme are found in animals a...

journal_title：Biochemical and biophysical research communications

authors： Bakker H,Lommen A,Jordi W,Stiekema W,Bosch D

更新日期：1999-08-11 00:00:00

abstract：:ATP is the universal energy currency but mysteriously its cellular concentration is much higher than that needed for providing energy. Recently ATP was decoded to act as a hydrotrope to dissolve liquid-liquid phase separation (LLPS) of FUS whose aggregation leads to ALS/FTD. By DIC microscopy and NMR, here we characte...

journal_title：Biochemical and biophysical research communications

authors： Kang J,Lim L,Song J

更新日期：2018-10-02 00:00:00

abstract：:Seleno compounds such as selenocystamine and seleno-D, L-cystine were found to catalyze the decomposition of S-nitrosothiols (e.g. S-nitroso-glutathione and S-nitroso-N-acetyl-D, L-penicillamine) in the presence of different thiols (e.g. glutathione, N-acetyl-D-penicillamine and 2-mercaptoethanol), and liberate nitric...

journal_title：Biochemical and biophysical research communications

authors： Hou Y,Guo Z,Li J,Wang PG

更新日期：1996-11-01 00:00:00

abstract：:We previously showed that SIRT1 deacetylase inhibits proliferation of hepatocellular carcinoma cells expressing hepatitis B virus (HBV) X protein (HBX), by destabilization of β-catenin. Here, we report another role for SIRT1 in HBX-mediated resistance to oxidative stress. Ectopic expression and enhanced activity of SI...

journal_title：Biochemical and biophysical research communications

authors： Srisuttee R,Koh SS,Malilas W,Moon J,Cho IR,Jhun BH,Horio Y,Chung YH

更新日期：2012-12-07 00:00:00

abstract：:Recently, we developed a novel system known as Full-length cDNA Over-eXpressor (FOX) gene hunting [T. Ichikawa, M. Nakazawa, M. Kawashima, H. Iizumi, H. Kuroda, Y. Kondou, Y. Tsuhara, K. Suzuki, A. Ishikawa, M. Seki, M. Fujita, R. Motohashi, N. Nagata, T. Takagi, K. Shinozaki, M. Matsui, The FOX hunting system: an alt...

journal_title：Biochemical and biophysical research communications

authors： Fujita M,Mizukado S,Fujita Y,Ichikawa T,Nakazawa M,Seki M,Matsui M,Yamaguchi-Shinozaki K,Shinozaki K

更新日期：2007-12-14 00:00:00

abstract：:We examined whether chondroitin sulfates (CSs) exert inhibitory effects on heparanase (Hpse), the sole endoglycosidase that cleaves heparan sulfate (HS) and heparin, which also stimulates chemokine production. Hpse-mediated degradation of HS was suppressed in the presence of glycosaminoglycans derived from a squid car...

journal_title：Biochemical and biophysical research communications

authors： Higashi N,Maeda R,Sesoko N,Isono M,Ishikawa S,Tani Y,Takahashi K,Oku T,Higashi K,Onishi S,Nakajima M,Irimura T

更新日期：2019-11-26 00:00:00

abstract：:Recent studies have demonstrated that adult cells such as pancreatic exocrine cells can be converted to pancreatic β-cells in a process called cell reprogramming. Enteroendocrine cells and β-cells share similar pathways of differentiation during embryonic development. Notably, enteroendocrine K cells express many of t...

journal_title：Biochemical and biophysical research communications

authors： Lee E,Ryu GR,Moon SD,Ko SH,Ahn YB,Song KH

更新日期：2014-01-17 00:00:00

abstract：:Two neuropeptides (DCCI and DCCII) in the adipokinetic/red pigment concentrating hormone-family have been isolated and purified from the corpora cardiaca of horseflies (Diptera : Tabanidae). Both peptides were purified by a sequence of three reversed phase-high performance liquid chromatographic steps. Amino acid anal...

journal_title：Biochemical and biophysical research communications

authors： Jaffe H,Raina AK,Fraser BA,Keim P,Rao KR,Zhang YS,Lancaster JL,Hayes DK

更新日期：1988-03-15 00:00:00

abstract：:PRA1 (prenylated Rab acceptor) is a general regulator of Rab proteins, while RILP (Rab interacting lysosomal protein) is a specific effector for Rab7. It has been shown that PRA1 interacts with Rab proteins and with VAMP2. Therefore PRA1 is probably an important factor for membrane traffic, linking together the functi...

journal_title：Biochemical and biophysical research communications

authors： Bucci C,De Gregorio L,Bruni CB

更新日期：2001-08-31 00:00:00

abstract：:Adenovirus vector is one of the most widely used vectors in gene therapy applications for the treatment of diverse human diseases including cancer. In this study, we showed that infection with E1E3-deleted recombinant human adenovirus serotype 5 reduced human telomerase reverse transcriptase (hTERT) mRNA levels in hep...

journal_title：Biochemical and biophysical research communications

authors： Lee CH,Kim HW,Kim T,Lee SW

更新日期：2015-03-20 00:00:00

abstract：:Neuromedin K and neuromedin L are novel mammalian tachykinins isolated from porcine spinal cord. We have developed a highly sensitive radioimmunoassay for neuromedin K. Since the radioimmunoassay for neuromedin K has significant crossreactivity with neuromedin L and substance P, we can simultaneously determine the tis...

journal_title：Biochemical and biophysical research communications

authors： Minamino N,Masuda H,Kangawa K,Matsuo H

更新日期：1984-11-14 00:00:00