当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Identification of a novel autoantigen UACA in patients with panuveitis.

Identification of a novel autoantigen UACA in patients with panuveitis.

Abstract：

:To identify the target autoantigens in Vogt-Koyanagi-Harada disease, we made use of an immunoscreening of a bovine uveal cDNA expression library with serum samples obtained from patients with Vogt-Koyanagi-Harada disease. We identified a novel bovine antigen and homologous human autoantigen and designated it as UACA (uveal autoantigen with coiled coil domains and ankyrin repeats). mRNA of human UACA is expressed most abundantly in skeletal muscles and in various human tissues, including choroid, retina, and epidermal melanocytes. IgG autoantibodies were quantitated in an ELISA, using recombinant C-terminal 18.0% fragment of human UACA. The prevalence of IgG anti-UACA autoantibodies in patients with panuveitis (Vogt-Koyanagi-Harada disease, Behçet's disease, sarcoidosis) was significantly higher than that in healthy controls (19.6-28.1% vs 0%, P < 0.05) indicating that autoimmunity directed against UACA is a common phenomenon in these diseases.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yamada K,Senju S,Nakatsura T,Murata Y,Ishihara M,Nakamura S,Ohno S,Negi A,Nishimura Y

doi

10.1006/bbrc.2001.4189

subject

Has Abstract

pub_date

2001-02-02 00:00:00

pages

1169-76

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(01)94189-0

journal_volume

280

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • FilGAP regulates distinct stages of epithelial tubulogenesis.

    abstract：:Epithelial cells form a globular organ-like multi-cellular structure called cyst when cultured in extracellular matrix. The cyst generates extension followed by cell chains and tubules in response to hepatocyte growth factor (HGF). The Rho family small GTPases play essential roles for tubulogenesis. FilGAP, a Rac spec...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.04.187

    authors： Zuinen T,Tsutsumi K,Ohta Y

    更新日期：2019-06-30 00:00:00

  • Eupatilin, an activator of PPARα, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice.

    abstract：:Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is the main lipophilic flavonoid obtained from the Artemisia species. Eupatilin has been reported to have anti-apoptotic, anti-oxidative and anti-inflammatory activities. Previously, we found that eupatilin increases transcriptional activity and expression of peroxis...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.01.098

    authors： Jung Y,Kim JC,Park NJ,Bong SK,Lee S,Jegal H,Jin LT,Kim SM,Kim YK,Kim SN

    更新日期：2018-02-05 00:00:00

  • Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor.

    abstract：:Staurosporine (STAR), a potent protein kinase C (PKC) antagonist, was found to modulate the chemoattractant-induced respiratory burst of human polymorphonuclear leukocytes (PMNs) according to drug concentration. Low STAR concentrations from 10 to 200 nM potentiated the N-formyl-methionyl-leucyl-phenylalanine (fMLP) an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91675-i

    authors： Combadière C,Hakim J,Giroud JP,Périanin A

    更新日期：1990-04-16 00:00:00

  • Conserved structure and promoter sequence similarity in the mouse and human genes encoding the zinc finger factor BERF-1/BFCOL1/ZBP-89.

    abstract：:We have characterized the genomic structure of the mouse Zfp148 gene encoding Beta-Enolase Repressor Factor-1 (BERF-1), a Kruppel-like zinc finger protein involved in the transcriptional regulation of several genes, which is also termed ZBP-89, BFCOL1. The cloned Zfp148 gene spans 110 kb of genomic DNA encompassing th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4753

    authors： Feo S,Antona V,Cammarata G,Cavaleri F,Passantino R,Rubino P,Giallongo A

    更新日期：2001-04-27 00:00:00

  • Antisense suppression of p107 inhibits 3T3-L1 adipocyte differentiation.

    abstract：:The murine 3T3-L1 preadipocyte cell line is well characterized for its capacity to undergo differentiation into adipocytes under appropriate hormonal stimulation. p107, a member of the retinoblastoma tumor suppressor gene family has been shown to be dramatically upregulated during the early requisite clonal expansion ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.4886

    authors： May JS,Prince AM,Lyle RE,McGehee RE Jr

    更新日期：2001-05-18 00:00:00

  • Structural requirements of chromokinesin Kif4A for its proper function in mitosis.

    abstract：:Human Kif4A is a member of the Kinesin-4 family of kinesins. Kif4A is thought to be a bona fide chromokinesin because it possesses a motor domain and associates with condensed chromosomes during mitosis. Genetic deletion of Kif4A promotes tumorigenic phenotypes in mouse embryonic cells. Kif4A is critical for mitotic r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.05.065

    authors： Wu G,Chen PL

    更新日期：2008-08-01 00:00:00

  • Tumor promoting phorbol diesters: substrates for diacylglycerol lipase.

    abstract：:Enzyme activity in rat serum was examined utilizing the potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and various glycerolipids as substrates. The serum activity was specific for hydrolysis of the long chain tetradecanoate moiety of TPA, hydrolyzed mono- and diacylglycerols, but was not effective ag...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)90395-4

    authors： Cabot MC

    更新日期：1984-08-30 00:00:00

  • Activated p53 induces NF-kappaB DNA binding but suppresses its transcriptional activation.

    abstract：:NF-kappaB plays an important role in oncogenesis. Recently, we have demonstrated that loss of p53 function enhances DNA binding and transcriptional activities of NF-kappaB via IKKalpha and IKKbeta, and that glycolysis, activated by NF-kappaB, has an integral role in oncogene-induced cell transformation. Here, we show ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.05.021

    authors： Kawauchi K,Araki K,Tobiume K,Tanaka N

    更新日期：2008-07-18 00:00:00

  • Atrial natriuretic peptides stimulate renal gluconeogenesis.

    abstract：:Atrial natriuretic peptide (5-28AA; ANP) and atrial extract (ANS) stimulated rat renal gluconeogenesis in cortical tubule suspension in a dose dependent fashion only from substrates that enter gluconeogenesis via phosphoenol-pyruvate carboxylase. The effects of ANP and ANS were significantly potentiated by cAMP and cG...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91967-9

    authors： Obara T,Yamada H,Nakada J,Endou H

    更新日期：1985-06-28 00:00:00

  • FoxA1 as a lineage-specific oncogene in luminal type breast cancer.

    abstract：:The forkhead transcription factor FoxA1 is thought to be involved in mammary tumorigenesis. However, the precise role of FoxA1 in breast cancer development is controversial. We examined expression of FoxA1 in 35 human breast cancer cell lines and compared it with that of ErbB2, a marker of poor prognosis in breast can...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.11.064

    authors： Yamaguchi N,Ito E,Azuma S,Honma R,Yanagisawa Y,Nishikawa A,Kawamura M,Imai J,Tatsuta K,Inoue J,Semba K,Watanabe S

    更新日期：2008-01-25 00:00:00

  • Demonstration of the phosphorylation-dependent interaction of tryptophan hydroxylase with the 14-3-3 protein.

    abstract：:The molecular mechanism of the phosphorylation-dependent activation of tryptophan hydroxylase is studied with respect to the role of the 14-3-3 protein. Reexamination of the system reconstituted with the purified TRH and the 14-3-3 protein showed that the level of the TRH activity correlated with the extent of the Ca2...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.1796

    authors： Furukawa Y,Ikuta N,Omata S,Yamauchi T,Isobe T,Ichimura T

    更新日期：1993-07-15 00:00:00

  • Regional distribution of metorphamide in rat and guinea pig brain.

    abstract：:A specific radioimmunoassay was developed for metorphamide, an endogenous, amidated opioid octapeptide, originally isolated from bovine brain and human pheochromocytoma tissues. The radioimmunoassay was used to determine the concentration of immunoreactive metorphamide in extracts from dissected regions of rat and gui...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91174-4

    authors： Sonders M,Barchas JD,Weber E

    更新日期：1984-08-16 00:00:00

  • Transient infiltration of neutrophils into the thymus following whole-body X-ray irradiation in IL-10 knockout mice.

    abstract：:IL-10 is known to suppress the inflammatory responses in a variety of experimental models. Because we previously found that whole-body X-irradiation causes massive apoptosis in the thymus and transient infiltration of neutrophils, in this study, we examined whether or not IL-10 is involved in the regulation of neutrop...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.02.043

    authors： Fujiwara H,Yamazaki T,Uzawa A,Nagata K,Kobayashi Y

    更新日期：2008-05-02 00:00:00

  • Hydroxylamine is a vasorelaxant and a possible intermediate in the oxidative conversion of L-arginine to nitric oxide.

    abstract：:Our objective was to determine whether hydroxylamine is a possible intermediate in the oxidative conversion of L-arginine to nitric oxide. Vasorelaxation by hydroxylamine is known to be mediated by nitric oxide. The vasorelaxant properties of hydroxylamine were examined using rat aortic rings and an isolated rat lung ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92169-4

    authors： DeMaster EG,Raij L,Archer SL,Weir EK

    更新日期：1989-08-30 00:00:00

  • Construction of preferential cDNA microarray specialized for human colorectal carcinoma: molecular sketch of colorectal cancer.

    abstract：:cDNA microarray analyses can be used to identify candidate genes that play important roles in human carcinogenesis. To gain insight into the molecular sketch of colorectal cancer, we have constructed cDNA microarrays specialized for colorectal cancer, which we named "Colonochip" by selecting genes that are expressed i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5277

    authors： Takemasa I,Higuchi H,Yamamoto H,Sekimoto M,Tomita N,Nakamori S,Matoba R,Monden M,Matsubara K

    更新日期：2001-08-03 00:00:00

  • Activation and deactivation of aflatoxin B1 in isolated rat hepatocytes.

    abstract：:Isolated rat hepatocytes took up [3H]-aflatoxin B1 during incubation with fifty percent of the aflatoxin B1 covalantly bound to cellular macromolecules. The amount of bound-aflatoxin B1 was proportional to the medium concentration of aflatoxin B1. The specific radioactivity (pmole/mg) of aflatoxin B1 found in the DNA ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)91201-9

    authors： Ch'ih JJ,Lin T,Devlin TM

    更新日期：1983-01-27 00:00:00

  • IGF2BP1 promotes LPS-induced NFκB activation and pro-inflammatory cytokines production in human macrophages and monocytes.

    abstract：BACKGROUND:Lipopolysaccharide (LPS)-induced macrophage/monocyte activation and pro-inflammatory cytokines production are important mediators for periodontitis progression. The current study tested the potential role of insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in the process. METHODS:THP-1 human ma...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.03.206

    authors： Xie J,Li Q,Zhu XH,Gao Y,Zhao WH

    更新日期：2019-06-11 00:00:00

  • Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells.

    abstract：:In rat basophilic leukemia cells (RBL-2H3) activation of the high affinity receptor for IgE induces tyrosine phosphorylation of PKC delta. We carried out solid phase synthesis of 15 amino acid long oligopeptides corresponding to the sequences around each of the 19 tyrosine residues in PKC delta. Only three oligopeptid...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2370

    authors： Szallasi Z,Denning MF,Chang EY,Rivera J,Yuspa SH,Lehel C,Olah Z,Anderson WB,Blumberg PM

    更新日期：1995-09-25 00:00:00

  • Dual effect of insulin on in vitro leptin secretion by adipose tissue.

    abstract：:Although it is widely accepted that insulin stimulates leptin secretion, a dual action was observed using a validated in vitro system, i.e., an early (less than 48 h) inhibitory action, followed later (48-96 h) by a clear-cut stimulation. While the inhibitory phase was observed at every glucose concentration tested (f...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3506

    authors： Casabiell X,Piñeiro V,De la Cruz LF,Gualillo O,Folgar L,Diéguez C,Casanueva FF

    更新日期：2000-09-24 00:00:00

  • Mutants of Escherichia coli H+-ATPase defective in the delta subunit of F1 and the b subunit of F0.

    abstract：:Complete nucleotide sequence of the genes for subunits of the H+ ATPase of E.coli has been determined and several hybrid plasmids carrying various portions of these genes have been constructed. Genetic complementation and recombination tests of about forty mutants of E.coli defective in the ATPase were performed using...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(83)80128-4

    authors： Noumi T,Kanazawa H

    更新日期：1983-02-28 00:00:00

  • Multi-strand binding of nuclear factors to a repressor of mouse mammary tumor virus transcription can be distinguished kinetically.

    abstract：:NRE1 is a DNA sequence element in the long terminal repeat of mouse mammary tumor virus that represses viral transcription in mature T cells. In addition to double-stranded binding activity, factors in Jurkat T cell nuclear extracts bind specifically to each of the two single-strands of NRE1. Here we show that binding...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1514

    authors： Rodda DJ,Giffin W,Haché RJ

    更新日期：1995-04-06 00:00:00

  • Effects of metal ions on the binding activity of the human leukocyte leukotriene B4 receptor.

    abstract：:The specific binding of leukotriene B4 to its receptor on human leukocyte membranes was enhanced in a dose-dependent manner by metal ions. Mg2+ and Ca2+ were the most potent followed by Mn2+ and Co2+. These divalent cations increased receptor density and did not affect the binding affinity. Addition of the same divale...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6953

    authors： Ng CF,Haeggström JZ,Samuelsson B

    更新日期：1997-07-18 00:00:00

  • High-active truncated luciferase of copepod Metridia longa.

    abstract：:The technology of real-time imaging in living cells is crucial for understanding of intracellular events. For this purpose, bioluminescent reporters have been introduced as sensitive and convenient tools. Metridia luciferase (MLuc) from the copepod Metridia longa is a coelenterazine-dependent luciferase containing a n...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.11.063

    authors： Markova SV,Burakova LP,Vysotski ES

    更新日期：2012-01-06 00:00:00

  • GATA4 loss-of-function mutation underlies familial dilated cardiomyopathy.

    abstract：:The cardiac transcription factor GATA4 is essential for cardiac development, and mutations in this gene have been implicated in a wide variety of congenital heart diseases in both animal models and humans. However, whether mutated GATA4 predisposes to dilated cardiomyopathy (DCM) remains unknown. In this study, the wh...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.09.023

    authors： Li RG,Li L,Qiu XB,Yuan F,Xu L,Li X,Xu YJ,Jiang WF,Jiang JQ,Liu X,Fang WY,Zhang M,Peng LY,Qu XK,Yang YQ

    更新日期：2013-10-04 00:00:00

  • Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3.

    abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine playing roles in the immune system, hematopoiesis, and acute phase reactions. IL-6 also regulates the growth of various types of human malignant tumors. Here we demonstrate that IL-6-induced gene expression was suppressed by a specific heat-shock protein 90 (Hsp90) in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02941-8

    authors： Sato N,Yamamoto T,Sekine Y,Yumioka T,Junicho A,Fuse H,Matsuda T

    更新日期：2003-01-24 00:00:00

  • MAPK and Akt act cooperatively but independently on hypoxia inducible factor-1alpha in rasV12 upregulation of VEGF.

    abstract：:Oncogenic ras upregulates the expression of VEGF through the activation of the transcriptional enhancer hypoxia inducible factor-1alpha (HIF-1alpha) by a still poorly understood mechanism. Here, we demonstrate that both the Raf/MEK/MAPK and the PI3 kinase/Akt signaling pathways potently and additively stimulate the ex...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5532

    authors： Sodhi A,Montaner S,Miyazaki H,Gutkind JS

    更新日期：2001-09-14 00:00:00

  • Human serum immunoglobulin G3 subclass bound preferentially to asialo-, agalactoimmunoglobulin A1/Sepharose.

    abstract：:As we reported before, exoglycosidase treatment of human serum IgA1 changed it to a sticky molecule. In order to examine the presence of the specific binding protein to the sticky IgA1 in human serum, IgA1, asialo-IgA1 (IgA1-S) and asialo-, agalacto-IgA1 (IgA1-SG)/Sepharose column chromatography of normal human serum ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.1369

    authors： Iwase H,Yokozeki Y,Hiki Y,Tanaka A,Kokubo T,Sano T,Ishii-Karakasa I,Hisatani K,Kobayashi Y,Hotta K

    更新日期：1999-10-22 00:00:00

  • Combination of the chemotherapeutic agent 5-fluorouracil with an inhibitor of its catabolism results in increased micronucleus induction.

    abstract：:The rate limiting step in 5-fluorouracil catabolism is catalyzed by the enzyme dihydropyrimidine dehydrogenase. Since degradation of 5-fluorouracil decreases its efficacy in chemotherapy, the inhibition of its catabolism is a promising tool. We investigated the formation of micronuclei in vitro in mouse L5178Y cells. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2299

    authors： Stopper H,Kühnel A,Podschun B

    更新日期：1994-09-15 00:00:00

  • Leukemia inhibitory factor relaxes arteries through endothelium-dependent mechanism.

    abstract：:Leukemia inhibitory factor (LIF) is a cytokine, which inhibits angiogenesis and decreases endothelial cell proliferation and migration, suggesting that LIF may modulate vascular tone. In this study, we examined the effects of LIF on the tone of rat arteries. The isometric tension of ring preparations from rat superior...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00493-X

    authors： Kimura K,Tsuda K,Moriwaki C,Kawabe T,Hamada M,Obana M,Baba A,Hano T,Nishio I

    更新日期：2002-06-07 00:00:00

  • Acidosis leads to neurological disorders through overexciting cortical pyramidal neurons.

    abstract：:The patients suffering from acidosis usually sign psychological deficits. The cerebral dysfunction is reportedly caused by an acid-induced functional impairment of GABAergic neurons; however, the role of pyramidal neurons in this process remains unclear. By using electrophysiological method and changing extracellular ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.08.008

    authors： Zhao H,Cai Y,Yang Z,He D,Shen B

    更新日期：2011-11-18 00:00:00