Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells.

abstract：:Serine palmitoyltransferase long chain-1 (SPTLC1), which is the rate-limiting enzyme for sphingolipid biosynthesis, has been indicated to be essential for carcinoma cell survival and proliferation in recent, but its role in the regulation of renal cell carcinoma (RCC) remains unknown. In the present study, we found th...

journal_title：Biochemical and biophysical research communications

authors： Kong Z,Guo X,Zhao Z,Wu W,Luo L,Zhu Z,Yin S,Cai C,Wu W,Wang D,Liu Y,Duan X

更新日期：2019-11-26 00:00:00

abstract：:Neurotensin (NT), a gastrointestinal (GI) hormone, binds its receptor (NTR) to stimulate proliferation of normal and neoplastic GI tissues; the molecular mechanisms remain largely undefined. Mitogen-activated protein kinases (MAPKs) are a family of intracellular kinases that transmit mitogenic signals by translocating...

journal_title：Biochemical and biophysical research communications

authors： Ehlers RA,Zhang Y,Hellmich MR,Evers BM

更新日期：2000-03-24 00:00:00

abstract：:NRE1 is a DNA sequence element in the long terminal repeat of mouse mammary tumor virus that represses viral transcription in mature T cells. In addition to double-stranded binding activity, factors in Jurkat T cell nuclear extracts bind specifically to each of the two single-strands of NRE1. Here we show that binding...

journal_title：Biochemical and biophysical research communications

authors： Rodda DJ,Giffin W,Haché RJ

更新日期：1995-04-06 00:00:00

abstract：:Expression of retinoic acid receptor-beta (RAR-beta) is frequently lost in tobacco-related cancers. Benzo[a]pyrene diol epoxide (BPDE) is an active metabolite of tobacco procarcinogen benzo[a]pyrene and plays an important role in tobacco carcinogenesis. We therefore exposed SV-40 immortalized esophageal epithelial cel...

journal_title：Biochemical and biophysical research communications

authors： Song S,Xu XC

更新日期：2001-03-09 00:00:00

abstract：:Tumour-secreted vascular endothelial growth factor (VEGF) exerts a number of effects which are important in tumour pathology, including stimulation of angiogenesis and permeabilisation of tumour-associated vasculature. In this study we have examined the possibility that VEGF may also play an autocrine role in tumour g...

journal_title：Biochemical and biophysical research communications

authors： Liu B,Earl HM,Baban D,Shoaibi M,Fabra A,Kerr DJ,Seymour LW

更新日期：1995-12-26 00:00:00

abstract：:Matrix vesicles (MVs) are cell-derived membranous entities crucial for mineral formation in the extracellular matrix. One of the dominant groups of constitutive proteins present in MVs, recognised as regulators of mineralization in norm and pathology, are annexins. In this report, besides the annexins already describe...

journal_title：Biochemical and biophysical research communications

authors： Cmoch A,Strzelecka-Kiliszek A,Palczewska M,Groves P,Pikula S

更新日期：2011-09-09 00:00:00

abstract：:We have cloned and functionally expressed a sodium-dependent human nucleoside transporter, hCNT2, from a CNS cancer cell line U251. Our cDNA clone of hCNT2 had the same predicted amino acid sequence as the previously cloned hCNT2 transporter. Of the several cell lines studied, the best hCNT2 transport function was obt...

journal_title：Biochemical and biophysical research communications

authors： Shin HC,Landowski CP,Sun D,Vig BS,Kim I,Mittal S,Lane M,Rosania G,Drach JC,Amidon GL

更新日期：2003-08-01 00:00:00

abstract：:Two genes expressing 70 kDa heat shock proteins were identified in Cyprinus carpio. The sequence similarities and the intron-interrupted structure of the coding regions indicate that carp Hsc70-1 and Hsc70-2 belong to the Hsp70 cognate subfamily. The expressions of the two hsc70 genes were followed by semi-quantitativ...

journal_title：Biochemical and biophysical research communications

authors： Ali KS,Dorgai L,Abrahám M,Hermesz E

更新日期：2003-08-01 00:00:00

abstract：:Increased ubiquitin-specific protease 5 (USP5) has been associated with tumorigenesis of malignancy including glioblastoma, melanoma and hepatocellular carcinoma. However, the role of USP5 in tumorigenesis of pancreatic ductal adenocarcinoma (PDAC) has not been studied yet. In this study, we demonstrated that USP5 was...

journal_title：Biochemical and biophysical research communications

authors： Li XY,Wu HY,Mao XF,Jiang LX,Wang YX

更新日期：2017-10-07 00:00:00

abstract：:We have previously reported that intraplatelet "cyclic AMP jumps" produced with newly synthesized photoactivatable cyclic AMP analogue, inhibited washed rat platelet aggregation and serotonin release as induced by thrombin. Using the same approach on human platelets, thrombin-induced platelet aggregation was dose-depe...

journal_title：Biochemical and biophysical research communications

authors： Blache D,Ciavatti M,Ponsin G,Nargeot J

更新日期：1987-07-15 00:00:00

abstract：:[2-14C]-trans-2-hexadecenoyl CoA (16:1) and [2-14C]-trans-2-cis-8,11,14-eicosatetraenoyl CoA (20:4) were chemically synthesized and employed as competitive substrates for the liver microsomal trans-2-enoyl CoA reductase component of the fatty acid chain elongation system. Both 7.5 microM and 15 microM 20:4 competitive...

journal_title：Biochemical and biophysical research communications

authors： Nagi MN,Cook L,Prasad MR,Cinti DL

更新日期：1986-10-15 00:00:00

abstract：:The circular RNA (circRNA) circEPSTI1 has been recently identified as a new cancer-associated circRNA in multiple types of cancer. However, the involvement of circEPSTI1 in non-small cell lung cancer (NSCLC) remains unexplored. The purpose of this study was to explore the expression pattern and function of circEPSTI1 ...

journal_title：Biochemical and biophysical research communications

authors： Yang T,Li M,Li H,Shi P,Liu J,Chen M

更新日期：2020-09-10 00:00:00

abstract：:Semicarbazide-sensitive amine oxidase (SSAO) activity in plasma is increased in diabetes, and in particular, in diabetic patients with vascular complications. It has been speculated that SSAO is involved in the development of such complications due to the production of cytotoxic compounds. In this work, we have induce...

journal_title：Biochemical and biophysical research communications

authors： Gokturk C,Nordquist J,Sugimoto H,Forsberg-Nilsson K,Nilsson J,Oreland L

更新日期：2004-12-17 00:00:00

abstract：:The second open reading frame of avian reovirus S1 gene segment encodes a 17 kDa non-structural protein, named p17. The biological role of p17 is fully unknown so far. Using trypan blue dye exclusion and MTT assay, we demonstrated that the ectopic expression of p17 results in the reduction of viable cell number and ce...

journal_title：Biochemical and biophysical research communications

authors： Liu HJ,Lin PY,Lee JW,Hsu HY,Shih WL

更新日期：2005-10-21 00:00:00

abstract：:We questioned whether glucocorticoids alter the known potent effect of serum to increase glucose transport and GLUT-1 expression in cultured L6 myotubes. Myotubes were exposed to serum-free medium for 24h in the presence or absence of 300 nM dexamethasone and subsequently treated for 8h with 10% serum or serum free me...

journal_title：Biochemical and biophysical research communications

authors： Sivitz WI,Pasley AM

更新日期：1995-01-05 00:00:00

abstract：:In this report we describe the initial characterization of murine, human, and Drosophila hesr-1 (for hairy and enhancer of split related-1) a novel evolutionary conserved family of hairy/enhancer of split homologs. Hesr-1 cDNAs display features typical of hairy and enhancer of split-type bHLH proteins including a N-te...

journal_title：Biochemical and biophysical research communications

authors： Kokubo H,Lun Y,Johnson RL

更新日期：1999-07-05 00:00:00

abstract：:Cancer/Testis antigen DDX53 shows high expression level in various tumors and is involved in anti-cancer drug resistance. However, the functional study of DDX53 in cervix cancer remains unknown. In this study, the role of DDX53 in taxol-resistance of cervix cancer cells was investigated. In taxol-resistant HelaTR cell...

journal_title：Biochemical and biophysical research communications

authors： Park SY,Kim WJ,Byun JH,Lee JJ,Jeoung D,Park ST,Kim Y

更新日期：2018-11-30 00:00:00

abstract：:The new potent tumor promoters teleocidin and debromoaplysiatoxin , which are structurally unrelated to phorbol esters, activate Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C). The concentrations of 12-O-tetradecanoylphorbol-13-acetate, teleocidin and debromoaplysiatoxin for half-maximum acti...

journal_title：Biochemical and biophysical research communications

authors： Fujiki H,Tanaka Y,Miyake R,Kikkawa U,Nishizuka Y,Sugimura T

更新日期：1984-04-30 00:00:00

abstract：:The ability of cholecystokinin (CCK) to elevate intracellular Ca2+ levels in small cell lung cancer cells was investigated using the fluorescent Ca2+ indicator Fura 2. CCK-8 elevated the cytosolic Ca2+ levels in cell line NCI-H345 in a dose dependent manner. Nanomolar concentration of CCK-8 elevated cytosolic Ca2+ lev...

journal_title：Biochemical and biophysical research communications

authors： Staley J,Fiskum G,Moody TW

更新日期：1989-08-30 00:00:00

abstract：:Amino acid transporter plays an important role in regulating mTOR signaling pathway. This study investigated the effects of reduced dietary protein levels on amino acid transporters and mTOR signaling pathway. A total of 54 weaning pigs were randomly allocated into a 3 × 3 factorial design, followed by slaughtering th...

journal_title：Biochemical and biophysical research communications

authors： Wang D,Wan X,Peng J,Xiong Q,Niu H,Li H,Chai J,Jiang S

更新日期：2017-04-01 00:00:00

abstract：:Topical nuclear magnetic resonance spectroscopy (NMR) using a solenoid transmit/receiver coil has been used to monitor the kinetics of intragastric utilization of [1-13C] glucose in mice in vivo. Using a double-tuned solenoid coil, signal to noise response was excellent and the natural abundance in vivo 13C spectra ob...

journal_title：Biochemical and biophysical research communications

authors： Field J,Irving MG,Brooks WM,Doddrell DM

更新日期：1984-09-28 00:00:00

abstract：:Atrial fibrillation (AF) is the most common cardiac arrhythmia in the clinic, and accounts for more than 15% of strokes. Mutations in cardiac sodium channel alpha, beta1 and beta2 subunit genes (SCN5A, SCN1B, and SCN2B) have been identified in AF patients. We hypothesize that mutations in the sodium channel beta3 subu...

journal_title：Biochemical and biophysical research communications

authors： Wang P,Yang Q,Wu X,Yang Y,Shi L,Wang C,Wu G,Xia Y,Yang B,Zhang R,Xu C,Cheng X,Li S,Zhao Y,Fu F,Liao Y,Fang F,Chen Q,Tu X,Wang QK

更新日期：2010-07-16 00:00:00

abstract：:The ontogeny of T-Kininogen expression in the rat liver was examined. Levels approximately 6 fold higher than seen in the adult liver are present during the perinatal period. Elevated levels are also seen in the maternal liver, beginning 5 days prior to parturition. The timing of induction in the fetal and maternal li...

journal_title：Biochemical and biophysical research communications

authors： Mann EA,Lingrel JB

更新日期：1991-01-31 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (Mpro) and the RNA-dependent RNA poly...

journal_title：Biochemical and biophysical research communications

authors： Jin Z,Wang H,Duan Y,Yang H

更新日期：2020-11-21 00:00:00

abstract：:Previously, we showed that several minor macromolecular glycolipids accounting for less than 5% of the lipoteichoic acid (LTA) fraction from Enterococcus hirae ATCC 9790 possess cytokine-inducing activity, whereas the purified LTA does not. In other words, the immunobiological activity of the LTA fraction reported in ...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto M,Imamura Y,Morichika T,Arimoto K,Takeuchi O,Takeda K,Akira S,Aoyama K,Tamura T,Kotani S,Suda Y,Kusumoto S

更新日期：2000-06-24 00:00:00

abstract：:This study investigates whether angiotensin converting enzyme (ACE) inhibitors can block high glucose-induced increase of angiotensin II (Ang II) levels in cultured rat mesangial cells. Incubation of cells with high glucose for 5 days increased Ang II in the cell media (extracellular) and cell lysates (intracellular) ...

journal_title：Biochemical and biophysical research communications

authors： Singh R,Leehey DJ

更新日期：2007-06-15 00:00:00

abstract：:Spinal muscular atrophy (SMA) is caused by mutations within the survival motor neuron 1 (SMN1) gene. These mutations result in the reduction of survival motor neuron (SMN) protein expression and SMN complex in spinal motor neurons and other tissues. SMN protein has been used as a therapeutic biomarker in recent SMA cl...

journal_title：Biochemical and biophysical research communications

authors： Arakawa M,Arakawa R,Tatsumi S,Aoki R,Saito K,Nomoto A

更新日期：2014-10-24 00:00:00

abstract：:Thrombomodulin (TM) is a cell-surface glycoprotein and a critical mediator of endothelial anticoagulant function. TM exists as both a chondroitin sulfate (CS) proteoglycan (PG) form and a non-PG form lacking a CS chain (α-TM); therefore, TM can be described as a part-time PG. Previously, we reported that α-TM bears an...

journal_title：Biochemical and biophysical research communications

authors： Izumikawa T,Kitagawa H

更新日期：2015-05-01 00:00:00

abstract：:Jmjd2c is a candidate oncogene that encodes histone lysine demethylase. In this study, we discovered that over-expression of Jmjd2c increased the expression of Mdm2 oncogene dependent on its demethylase activity, which led to the reduction of p53 tumor suppressor gene product in the cells. A chromatin immunoprecipitat...

journal_title：Biochemical and biophysical research communications

authors： Ishimura A,Terashima M,Kimura H,Akagi K,Suzuki Y,Sugano S,Suzuki T

更新日期：2009-11-13 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is produced by various normal and neoplastic tissues. Even if the physiological function(s) of PTHrP is unclear, evidence suggests that the protein may participate in the local regulation of smooth muscle contractility. We show here that PTHrP is produced in endothelial cell...

journal_title：Biochemical and biophysical research communications

authors： Rian E,Jemtland R,Olstad OK,Endresen MJ,Grasser WA,Thiede MA,Henriksen T,Bucht E,Gautvik KM

更新日期：1994-01-28 00:00:00