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Transient infiltration of neutrophils into the thymus following whole-body X-ray irradiation in IL-10 knockout mice.

Abstract：

:IL-10 is known to suppress the inflammatory responses in a variety of experimental models. Because we previously found that whole-body X-irradiation causes massive apoptosis in the thymus and transient infiltration of neutrophils, in this study, we examined whether or not IL-10 is involved in the regulation of neutrophil infiltration upon whole-body X-ray irradiation using IL-10 knockout mice. Although IL-10 was induced in the thymus on whole-body X-ray irradiation, apoptosis of thymocytes, neutrophil infiltration, and MIP-2 and KC production in the thymus were not affected by an IL-10 deficiency. Coculturing of bone marrow-derived macrophages with late apoptotic cells caused MIP-2 production, which was also not affected by an IL-10 deficiency. These results suggest the uniqueness of the inflammatory response induced by whole-body X-ray irradiation, which does not seem to be regulated by IL-10.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Fujiwara H,Yamazaki T,Uzawa A,Nagata K,Kobayashi Y

doi

10.1016/j.bbrc.2008.02.043

subject

Has Abstract

pub_date

2008-05-02 00:00:00

pages

432-6

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)00293-3

journal_volume

369

pub_type

杂志文章

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