MicroRNA-27a regulates angiotensin II-induced vascular smooth muscle cell proliferation and migration by targeting α-smooth muscle-actin in vitro.

abstract：:The discovery of small molecule kinase inhibitors for use as drugs is a promising approach for the treatment of cancer and other diseases, but the discovery of highly specific agents is challenging because over 850 kinases are expressed in mammalian cells. Systematic modification of the 4-anilino functionality of a se...

journal_title：Biochemical and biophysical research communications

authors： Bhattacharya SK,Cox ED,Kath JC,Mathiowetz AM,Morris J,Moyer JD,Pustilnik LR,Rafidi K,Richter DT,Su C,Wessel MD

更新日期：2003-07-25 00:00:00

abstract：:Survivin is a member of inhibitors of apoptosis proteins (IAPs), and also belongs to be a member of the chromosomal passenger complex (CPC) which has multiple functions including inhibition of apoptosis and regulation of cell division and SAC activity. Plk1 (polo-like kinase 1) associates with the spindle poles and al...

journal_title：Biochemical and biophysical research communications

authors： Sun SC,Liu HL,Sun QY

更新日期：2012-05-18 00:00:00

abstract：:Satellite cells are quiescent muscle stem cells that promote postnatal muscle growth and repair. When satellite cells are activated by myotrauma, they proliferate, migrate, differentiate, and ultimately fuse to existing myofibers. The remainder of these cells do not differentiate, but instead return to quiescence and ...

journal_title：Biochemical and biophysical research communications

authors： Nishimura T,Nozu K,Kishioka Y,Wakamatsu J,Hattori A

更新日期：2008-06-06 00:00:00

abstract：:Localization of ATP-binding cassette transporter isoform C1 (ABCC1) to the basolateral membrane of polarized cells is crucial for export of a variety of cellular metabolites; however, the mechanism regulating basolateral targeting of the transporter is poorly understood. Here we describe identification of a basolatera...

journal_title：Biochemical and biophysical research communications

authors： Emi Y,Harada Y,Sakaguchi M

更新日期：2013-11-08 00:00:00

abstract：:Understanding protein aggregation may hold important clues to understanding what goes wrong with protein folding in neurodegenerative disorders and in bioreactors in which proteins are overexpressed. Unfortunately, aggregates tend to be intractable to most standard methods of biochemical investigation. Thus, relativel...

journal_title：Biochemical and biophysical research communications

authors： Kundu B,Guptasarma P

更新日期：2002-04-26 00:00:00

abstract：:trans-Resveratrol (3,4',5-trihydroxystilbene; RES), a polyphenol found in particularly high concentrations in red wine, has recently attracted intense interest for its potentially beneficial effects on human health. Here, we report the effects of long-term exposure to micromolar concentrations of RES on antioxidant an...

journal_title：Biochemical and biophysical research communications

authors： Robb EL,Page MM,Wiens BE,Stuart JA

更新日期：2008-03-07 00:00:00

abstract：:To tailor tissue-type plasminogen activator (tPA) to possess an affinity for the integrins, several mutants were constructed by introducing the Arg-Gly-Asp (RGD) sequene into the tPA molecule. These mutants were expressed in COS-1 cells and partially purified by lysine-Sepharose chromatography. The RGD-dependent bindi...

journal_title：Biochemical and biophysical research communications

authors： Yamada T,Shimada Y,Kikuchi M

更新日期：1996-11-12 00:00:00

abstract：BACKGROUND:In diabetic retinopathy, prolonged high-level blood glucose induced significant impairments among various retinal tissues, including retinal pigment epithelial (RPE) cells. In an in vitro model of human RPE cells, we evaluated whether 7,8-Dihydroxyflavone (DHF) may effectively prevent high glucose-induced di...

journal_title：Biochemical and biophysical research communications

authors： Yu X,Liu Q,Wang X,Liu H,Wang Y

更新日期：2018-01-01 00:00:00

abstract：:The Fragile X protein FMRP is an RNA binding protein whose targets are not well known; yet, these RNAs may play an integral role in the disease's etiology. Using a biotinylated-FMRP affinity resin, we isolated RNAs from the parietal cortex of a normal adult that bound FMRP. These RNAs were amplified by differential di...

journal_title：Biochemical and biophysical research communications

authors： Sung YJ,Conti J,Currie JR,Brown WT,Denman RB

更新日期：2000-09-07 00:00:00

abstract：:alpha-Acaridial [2(E)-(4-methyl-3-pentenyl)butenedial] is a novel monoterpene secreted from the house dust mites. Because of its molecular nature of a highly reactive, small lipidic compound, we addressed whether alpha-acaridial might function as a haptenic allergen that induced allergic contact dermatitis. Mice sensi...

journal_title：Biochemical and biophysical research communications

authors： Sasai T,Hirano Y,Maeda S,Matsunaga I,Otsuka A,Morita D,Nishida R,Nakayama H,Kuwahara Y,Sugita M,Mori N

更新日期：2008-10-24 00:00:00

abstract：:Simple polyesters derived from poly(ethylene glycol)s and alpha, omega-dicarboxylic acids exhibit a broad range of activity in disrupting phospholipid membranes. This activity has been analyzed by measuring the release of liposome-encapsulated 5(6)-carboxy-fluorescein (CF). Comparison with an analogous monomeric surfa...

journal_title：Biochemical and biophysical research communications

authors： Regen SL,Jayasuriya N,Fabianowski W

更新日期：1989-03-15 00:00:00

abstract：:Stress associated proteins (SAPs) in plants contain A20-type zinc finger (A20_ZF) domains and are involved with abiotic stress response. A20-type zinc finger domains in animals reportedly recognize ubiquitin as a regulatory signal in cell. However, it remains unclear whether A20_ZF domains in plants perform similar ro...

journal_title：Biochemical and biophysical research communications

authors： Choi H,Han S,Shin D,Lee S

更新日期：2012-03-09 00:00:00

abstract：:A 67 kDa cytosolic FERM domain containing protein having significant protein tyrosine phosphatases activity (PTPL) has been purified to homogeneity from Setaria cervi, a bovine filarial parasite. The MALDI-MS/MS analysis of the purified protein revealed 16 peptide peaks showing nearest match to Brugia malayi Moesin/ez...

journal_title：Biochemical and biophysical research communications

authors： Singh N,Heneberg P,Singh N,Singh SK,Rathaur S

更新日期：2015-02-27 00:00:00

abstract：:Protein kinase D (PKD) has been established as a negative modulator of the c-Jun N-terminal kinase (JNK) signaling pathway. We previously demonstrated that induced expression of constitutively active PKD (PKD-S744/748E) that mimics phosphorylation by PKC is sufficient to attenuate epidermal growth factor (EGF) stimula...

journal_title：Biochemical and biophysical research communications

authors： Hurd C,Rozengurt E

更新日期：2003-03-21 00:00:00

abstract：:Sulfate plays an essential role in human growth and development. Here, we characterized the functional properties of the human Na(+)-sulfate cotransporter (hNaS2), determined its tissue distribution, and identified its gene (SLC13A4) structure. Expression of hNaS2 protein in Xenopus oocytes led to a Na(+)-dependent tr...

journal_title：Biochemical and biophysical research communications

authors： Markovich D,Regeer RR,Kunzelmann K,Dawson PA

更新日期：2005-01-28 00:00:00

abstract：:Here, we report on the first attempt to bioengineer tooth using a spontaneously immortalized mesenchymal cell line. To assess the odontogenic potential of this cell line, odontoblast-lineage cells (OLC) were re-associated with competent dental epithelium isolated from E14.5 mice. A novel three-dimensional organ germ c...

journal_title：Biochemical and biophysical research communications

authors： Arany S,Kawagoe M,Sugiyama T

更新日期：2009-03-27 00:00:00

abstract：:The effect of acetaminophen (APAP) dose on the cytochrome P450s responsible for its bioactivation was examined in control mice and mice treated with acetone to induce CYP2E1, or beta-napthaflavone to induce CYP1A2. In non-induced mice, 150 mg/kg APAP caused minimal hepatotoxicity and loss of CYP2E1- but not CYP1A2-dep...

journal_title：Biochemical and biophysical research communications

authors： Snawder JE,Roe AL,Benson RW,Roberts DW

更新日期：1994-08-30 00:00:00

abstract：:The homeodomain transcription factor Phox2b is one of the key determinants involved in the development of noradrenergic (NA) neurons in both the central nervous system (CNS) and the peripheral nervous system (PNS). Using yeast two-hybrid screening, we isolated a Phox2b interacting protein, Trim11, which belongs to TRI...

journal_title：Biochemical and biophysical research communications

authors： Hong SJ,Chae H,Lardaro T,Hong S,Kim KS

更新日期：2008-04-11 00:00:00

abstract：:Effects of hepatocyte growth factor (HGF) on gastric wound repair were assessed. Artificial wounds of uniform size were made by mechanical cell denudation in confluent rabbit gastric mucosal cell sheets. The changes in wound size were analyzed quantitatively. The wound repair process contained an initial migration sta...

journal_title：Biochemical and biophysical research communications

authors： Watanabe S,Hirose M,Wang XE,Maehiro K,Murai T,Kobayashi O,Nagahara A,Sato N

更新日期：1994-03-30 00:00:00

abstract：:We have examined the restriction digest patterns of CCGG sequences in Kiras, Ha-ras, and c-myc oncogenes in rat tracheal epithelial cells transformed in vitro by 7,12-dimethylbenz(a)anthracene, benzo(a)pyrene/12-O-tetradecanoylphorbol-13-acetate (TPA), or TPA alone. Oncogenes c-myc and Ha-ras in transformed cell lines...

journal_title：Biochemical and biophysical research communications

authors： Mass MJ,Schorschinsky NS,Lasley JA,Beeman DK,Austin SJ

更新日期：1989-10-31 00:00:00

abstract：:The core protein of the hepatitis C virus is derived from the N-terminal 191 amino acids of the viral polyprotein by proteolytic cleavage. In the current study, subcellular localizations of the HCV core and its beta-galactosidase fusion proteins in transfected cells were examined by indirect immunofluorescence and cyt...

journal_title：Biochemical and biophysical research communications

authors： Chang SC,Yen JH,Kang HY,Jang MH,Chang MF

更新日期：1994-12-15 00:00:00

abstract：:A stability map of local secondary structure of the mRNA of the triple-helical alpha 2(I) chain domain of chicken type I collagen was obtained by plotting the free energy of the optimal secondary structure of a local segment in mRNA against the segment position along a base sequence of the mRNA. It was found that the ...

journal_title：Biochemical and biophysical research communications

authors： Zama M

更新日期：1990-03-16 00:00:00

abstract：:We have previously reported that salmosin, a novel disintegrin, was isolated from Korean snake (Agkistrodon halys brevicaudus) venom and significantly inhibited solid tumor growth in mice by perturbation of tumor-specific angiogenesis via blocking alphavbeta3 integrin expressed on vascular endothelial cells. In this s...

journal_title：Biochemical and biophysical research communications

authors： Kang IC,Kim DS,Jang Y,Chung KH

更新日期：2000-08-18 00:00:00

abstract：:Synthesis of melanin starts from the conversion of L-tyrosine to 3,4-dihydroxyphenylalanine (L-dopa) and then the oxidation of L-dopa yields dopaquinone by tyrosinase. Therefore, tyrosinase inhibitors have been established as important constituents of depigmentation agents. Recently, polyhydroxystilbene compounds, whi...

journal_title：Biochemical and biophysical research communications

authors： Ohguchi K,Tanaka T,Kido T,Baba K,Iinuma M,Matsumoto K,Akao Y,Nozawa Y

更新日期：2003-08-08 00:00:00

abstract：:The cell membrane receptor for epidermal growth factor (EGF) appears to be a glycoprotein of Mr 170,000 and mediates the mitogenic and metabolic responses of cells with EGF receptors (EGF-R). Normal rat kidney (NRK) have about 3 X 10(5) EGF-R per cell. Upon transformation of NRK cells by Kirsten sarcoma virus, the tra...

journal_title：Biochemical and biophysical research communications

authors： Chua CC,Geiman DE,Schreiber AB,Ladda RL

更新日期：1984-01-30 00:00:00

abstract：:Human myogenic cells have limited ability to proliferate in culture. Although forced expression of telomerase can immortalize some cell types, telomerase alone delays senescence of human primary cultured myogenic cells, but fails to immortalize them. In contrast, constitutive expression of both telomerase and the E7 g...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto N,Kiyono T,Wada MR,Shimizu S,Yasumoto S,Inagawa M

更新日期：2006-10-06 00:00:00

abstract：:Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders and is characterized by impaired attention, hyperactivity, and impulsivity. While multiple etiologies are implicated in ADHD, its underlying mechanism(s) remain unclear. Although previous studies have suggested dysre...

journal_title：Biochemical and biophysical research communications

authors： Nguyen Nguyen HT,Kato H,Sato H,Yamaza H,Sakai Y,Ohga S,Nonaka K,Masuda K

更新日期：2019-06-11 00:00:00

abstract：:The myelin basic proteins (MBPs) are a family of polypeptides that are predominantly expressed in the nervous system where they play a major role in myelination. We have generated four lines of transgenic mice carrying a transgene in which 1.34 kb of the 5'-flanking sequence of the mouse MBP gene was fused upstream of...

journal_title：Biochemical and biophysical research communications

authors： Asipu A,Mellor AL,Blair GE

更新日期：2001-11-09 00:00:00

abstract：:Receptor binding properties of the hemoglobin-derived nonapeptide VV-hemorphin 7 (Val-Val-Tyr-Pro-Trp-Thr-Gln-Arg-Phe-OH) were studied using both the unlabelled form and tritium-labelled derivative of the peptide. In binding studies using selective opioid radioligands, VV-hemorphin 7 exhibited a rank order of potency ...

journal_title：Biochemical and biophysical research communications

authors： Szikra J,Benyhe S,Orosz G,Darula Z,Piot JM,Fruitier I,Monory K,Hanoune J,Borsodi A

更新日期：2001-03-02 00:00:00

abstract：:The Notch protooncogene encodes a receptor important for determination and differentiation of many cell types, and is conserved between vertebrates and invertebrates. It has been suggested that the secreted protein scabrous (sca) might be a Notch ligand acting in the peripheral nervous system. The sca protein was puri...

journal_title：Biochemical and biophysical research communications

authors： Lee EC,Baker NE

更新日期：1996-08-23 00:00:00