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gp300sca is not a high affinity Notch ligand.

Abstract：

:The Notch protooncogene encodes a receptor important for determination and differentiation of many cell types, and is conserved between vertebrates and invertebrates. It has been suggested that the secreted protein scabrous (sca) might be a Notch ligand acting in the peripheral nervous system. The sca protein was purified and a cell line expressing 18,000 Notch molecules per cell surface used to test sca binding by coimmunoprecipitation, cell adhesion assays, and binding with labeled sca. No interaction was detected between gp300sca and Notch or the related protein Delta, suggesting that sca acts through a distinct mechanism.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Lee EC,Baker NE

doi

10.1006/bbrc.1996.1241

subject

Has Abstract

pub_date

1996-08-23 00:00:00

pages

720-5

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)91241-3

journal_volume

225

pub_type

杂志文章

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