Presynaptic GABA(B) receptors modulate synaptic facilitation and depression at distinct synapses in fusiform cells of mouse dorsal cochlear nucleus.


:The mammalian dorsal cochlear nucleus (DCN) is considered to contribute to the localization of the sound sources. Fusiform cells (FCs), principal projection neurons in the DCN, integrate two excitatory inputs from auditory nerve fibers (ANFs) and parallel fibers (PFs). Although an immunohistochemical study suggested presence of GABA(B) receptors at excitatory presynaptic terminals in the DCN, it has not been elucidated how GABA(B) receptors modulate the synaptic transmission to FCs. Here, we examined effects of baclofen on the transmission in vitro. Baclofen reduced both PF-EPSC and ANF-EPSC by reducing transmitter releases, and it enhanced the facilitation in PF-FC synapses and prevented the depression in ANF-FC synapses. The enhancement and prevention were prominent during high-frequency (50Hz) synaptic input, suggesting the activation of presynaptic GABA(B) receptors may optimize both PF-FC and ANF-FC synapses for high-frequency transmission. Postsynaptic GABA(B) receptors activated GIRK current and would further modulate the activity of FCs.


Irie T,Ohmori H




Has Abstract


2008-03-07 00:00:00














  • Elevated levels of beta defensin-1 mRNA in diabetic kidneys of GK rats.

    abstract::We previously described the isolation of CDK4, representing the 3(')end of an unknown mRNA, using differential display [Biophys. Res. Commun. 232 (1997) 49]. To determine the identity of the CDK4 gene, full-length CDK4 cDNA clones were isolated from a diabetic kidney cDNA library. DNA sequencing revealed that CDK4 rep...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Page RA,Malik AN

    更新日期:2003-10-17 00:00:00

  • The exogenously added small subunit of smooth muscle myosin phosphatase increases the Ca2+ sensitivity of the contractile apparatus in the permeabilized porcine renal artery.

    abstract::The effects of the small noncatalytic subunit of myosin light chain phosphatase (MLCPsr) on the Ca2+-induced contraction of smooth muscle were investigated in the Triton X-100-permeabilized porcine renal artery. The full-length recombinant chicken MLCPsr obtained by the bacterial expression system induced an additiona...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Zhou Y,Nishimura J,Hirano K,Kanaide H

    更新日期:1999-01-08 00:00:00

  • Phosphoglycerate mutase has essential arginyl residues.

    abstract::Phosphoglycerate mutase is inactivated by butanedione in borate buffer. Inactivation by 0.13 mM reagent correlates with the modification of one arginyl residue per subunit, and is prevented by either 2, 3-diphosphoglycerate or 3-phosphoglycerate. With 0.50 mM butanedione, inactivation is accompanied by the modificatio...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Borders CL Jr,Wilson BA

    更新日期:1976-12-20 00:00:00

  • Hypertonic induction of COX2 expression requires TonEBP/NFAT5 in renal epithelial cells.

    abstract::TonEBP/NFAT5 transcription factor is a master regulator of genes involved in osmoprotection. Cyclooxygenase 2 (COX2) has been reported to be a cytoprotective molecule in the inner renal medulla, where cells are physiologically exposed to the highest osmolality of the body. Our aim was to study whether COX2 expression ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Favale NO,Casali CI,Lepera LG,Pescio LG,Fernández-Tome MC

    更新日期:2009-04-10 00:00:00

  • Revisiting the oligomerization mechanism of Vibrio cholerae cytolysin, a beta-barrel pore-forming toxin.

    abstract::Vibrio cholerae cytolysin (VCC) is a membrane-damaging beta-barrel pore-forming toxin (beta-PFT). VCC causes permeabilization of the target membranes by forming transmembrane oligomeric beta-barrel pores. Oligomerization is a key step in the mode of action of any beta-PFT, including that of VCC. Earlier studies have i...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Rai AK,Chattopadhyay K

    更新日期:2016-06-03 00:00:00

  • Effects of synthetic retinoids and retinoic acid isomers on the expression of alkaline phosphatase in F9 teratocarcinoma cells.

    abstract::Expression of ALP in F9 teratocarcinoma cells is induced by all-trans retinoic acid (ATRA) (Gianni' et al., Biochem. J. 274: 673-678, 1991). The specific ligand for retinoic acid related receptors (RXRs), 9-cis retinoic acid (9-cis RA), and three synthetic analogs binding to the alpha, beta and gamma forms of the reti...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Gianni M,Zanotta S,Terao M,Garattini S,Garattini E

    更新日期:1993-10-15 00:00:00

  • Cholecystokinin elevates cytosolic calcium in small cell lung cancer cells.

    abstract::The ability of cholecystokinin (CCK) to elevate intracellular Ca2+ levels in small cell lung cancer cells was investigated using the fluorescent Ca2+ indicator Fura 2. CCK-8 elevated the cytosolic Ca2+ levels in cell line NCI-H345 in a dose dependent manner. Nanomolar concentration of CCK-8 elevated cytosolic Ca2+ lev...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Staley J,Fiskum G,Moody TW

    更新日期:1989-08-30 00:00:00

  • The alternative translation of synaptotagmin 1 mediates the non-classical release of FGF1.

    abstract::Although the extravesicular p40 domain of the transmembrane protein, p65 synaptotagmin (Syt) 1, is essential for the non-classical export of the signal peptide-less structure, FGF1, it was not possible to identify a specific intracellular protease responsible for the processing of p65 Syt1. Surprisingly, analysis of t...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Bagalá C,Kolev V,Mandinova A,Soldi R,Mouta C,Graziani I,Prudovsky I,Maciag T

    更新日期:2003-10-31 00:00:00

  • Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein.

    abstract::An XWnt8-Fz5 fusion protein synergizes with LRP6 to potently activate beta-catenin-dependent signaling. Here, we generated a fusion in which XWnt8 was fused to the N-terminus of LRP6 and show it synergizes with both Fz4 and Fz5 to potently transactivate beta-catenin-dependent Wnt signaling. Based on this, we hypothesi...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Holmen SL,Robertson SA,Zylstra CR,Williams BO

    更新日期:2005-03-11 00:00:00

  • Sequence of the gene, amoB, for the 43-kDa polypeptide of ammonia monoxygenase of Nitrosomonas europaea.

    abstract::The sequence for the 3' portion of amoB, a gene encoding a 43-kDa polypeptide component ammonia monooxygenase of Nitrosomonas europaea, is presented. The derived polypeptide has no homology with other known proteins. AmoA and amoB are the only open reading frames in the putative amo operon. ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Bergmann DJ,Hooper AB

    更新日期:1994-10-28 00:00:00

  • Tyrosine phosphorylation of vinculin at position 1065 modifies focal adhesion dynamics and cell tractions.

    abstract::Focal adhesions (FAs) connect the cellular actin cytoskeleton via integrin with the extracellular matrix. They comprise of many structural and signaling proteins which are highly dynamic, well regulated, and responsible for the sensing of physical properties from the environment. Vinculin is a protein that incorporate...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Küpper K,Lang N,Möhl C,Kirchgessner N,Born S,Goldmann WH,Merkel R,Hoffmann B

    更新日期:2010-09-03 00:00:00

  • Human trophoblast noncoding RNA suppresses CIITA promoter III activity in murine B-lymphocytes.

    abstract::Trophoblasts lack expression of all classical MHC antigens. Determination of the mechanism involved could provide insight into selective gene suppression and allograft tolerance. Suppression of class II expression in trophoblasts is secondary to dominant negative trans-acting factors that suppress class II transactiva...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Geirsson A,Lynch RJ,Paliwal I,Bothwell AL,Hammond GL

    更新日期:2003-02-14 00:00:00

  • Peroxynitrite reacts with biological nitrogen-containing cyclic molecules by a radical pathway, as demonstrated by ultraweak luminescence coupled with ESR technique.

    abstract::Ultraweak luminescence (uwCL) was coupled with electron spin resonance to study the reactions of 3 heterocyclic compounds (tryptophan, serotonin and imidazole) with peroxynitrite at pH 8.7. Tryptophan and serotonin reacted with emission of a flash peak of light (5 s) followed by a long-living light emission of +/- 80 ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Mouithys-Mickalad A,Kohnen S,Deby C,Noels AF,Lamy M,Deby-Dupont G

    更新日期:1999-06-07 00:00:00

  • Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002.

    abstract::In order to study the role of phosphatidylinositol-3-kinase (PI3K) in insulin action, we employed a specific inhibitor of PI3K, LY294002, and measured five biological functions of insulin in mouse 3T3 fibroblasts overexpressing human insulin receptors. LY294002 had no effect on tyrosine phosphorylation of both the ins...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Sanchez-Margálet V,Goldfine ID,Vlahos CJ,Sung CK

    更新日期:1994-10-28 00:00:00

  • Effect of retinoic acid on the acylation of phospholipids in granulocytes in vitro.

    abstract::The influence of retinoic acid on the incorporation of [1-14C]palmitic acid and [1-14C]arachidonic acid into phospholipids was examined in guinea pig peritoneal granulocytes. All-trans-retinoic acid inhibited the incorporation of both fatty acids into phosphatidic acid and phosphatidylinositol. However, it stimulated ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Tou J

    更新日期:1983-07-18 00:00:00

  • Effect of cysteamine on redox-sensitive thiol-containing proteins in the duodenal mucosa.

    abstract::Recent studies from our laboratory demonstrated that Egr-1 is upregulated in the rat duodenal mucosa during cysteamine-induced duodenal ulceration and that antisense egr-1 oligonucleotide aggravates the duodenal ulcers. This study was aimed to determine the effects of cysteamine on redox-sensitive Egr-1 transcriptiona...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Khomenko T,Deng X,Jadus MR,Szabo S

    更新日期:2003-10-03 00:00:00

  • A novel Ca2+/calmodulin-dependent protein kinase lacking autophosphorylation activity in the rabbit heart.

    abstract::We report the discovery, semi-purification and characterization of a novel Ca2+/calmodulin-dependent protein kinase (peak I kinase) using syntide 2 as a substrate from the rabbit heart. In the study of dependence of peak I kinase on the concentration of calmodulin, half-maximal activation was obtained at approx. 2.0 x...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Uemura A,Okazaki K,Takesue H,Matsubara T,Hidaka H

    更新日期:1995-06-15 00:00:00

  • Evidence for translational repression of the SOCS-1 major open reading frame by an upstream open reading frame.

    abstract::The suppressor of cytokine signalling 1 protein (SOCS-1) belongs to a novel family of cytokine inducible factors which function as inhibitors of the JAK/STAT pathway. While SOCS-1 previously has been described as a single-exon gene, here we present evidence for an additional 5' exon, separated by a 509 bp intron from ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Schlüter G,Boinska D,Nieman-Seyde SC

    更新日期:2000-02-16 00:00:00

  • Leukemia inhibitory factor relaxes arteries through endothelium-dependent mechanism.

    abstract::Leukemia inhibitory factor (LIF) is a cytokine, which inhibits angiogenesis and decreases endothelial cell proliferation and migration, suggesting that LIF may modulate vascular tone. In this study, we examined the effects of LIF on the tone of rat arteries. The isometric tension of ring preparations from rat superior...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kimura K,Tsuda K,Moriwaki C,Kawabe T,Hamada M,Obana M,Baba A,Hano T,Nishio I

    更新日期:2002-06-07 00:00:00

  • The cross roles of sphingosine kinase 1/2 and ceramide glucosyltransferase in cell growth and death.

    abstract::Sphingosine-1-phosphate is synthesized by two sphingosine kinases, cytosolic SK1 and nuclear SK2 but SK2 expression was much higher than SK1in mouse skin fibroblasts. However, in SK2-/- cells, SK1 expression was markedly increased to SK2 levels whereas in SK1-/- cells, SK2 expression was unaffected. Ceramide, glucosyl...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Qin J,Kilkus JP,Dawson G

    更新日期:2018-06-07 00:00:00

  • Modelling the peptide receptor interaction: selectivity of the oxytocin receptor.

    abstract::In this study the interactions of oxytocin with the transmembrane region of the oxytocin receptor were modelled in order to explain the selective binding of oxytocin and vasopressin. Three sites of interaction in the receptors were identified by sequence comparison and model building. Both receptors share one site, wh...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hakala JM

    更新日期:1994-08-15 00:00:00

  • Cholestane-3β, 5α, 6β-triol suppresses neuronal hyperexcitability via binding to voltage-gated sodium channels.

    abstract::Neuronal hyperexcitability is identified as a critical pathological basis of epileptic seizures. Cholestane-3β, 5α, 6β-triol (Triol) is a major metabolic oxysterol of cholesterol. Although its neuroprotective effect on ischemia-induced neuronal injury and negative modulation of voltage-gated sodium (Nav) channels were...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Tang L,Yan M,Leng T,Yin W,Cai S,Duan S,Zhu W,Lin S,Huang J,Yan G,Zheng G,Chen Y

    更新日期:2018-01-29 00:00:00

  • Parietal endoderm secreted S100A4 promotes early cardiomyogenesis in embryoid bodies.

    abstract::Cardiomyogenesis is influenced by factors secreted by anterior-lateral and extra-embryonic endoderm. Differentiation of embryonic stem cells in embryoid bodies allows to study the influence of growth factors on cardiomyogenesis. By these means SPARC was identified as a new factor enhancing cardiomyogenesis [M. Stary, ...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Stary M,Schneider M,Sheikh SP,Weitzer G

    更新日期:2006-05-05 00:00:00

  • Production of recombinant xenotransplantation antigen in Escherichia coli.

    abstract::The synthesis of sufficient amounts of oligosaccharides is the bottleneck for the study of their biological function and their possible use as drug. As an alternative for chemical synthesis, we propose to use Escherichia coli as a "living factory." We have addressed the production of the Galp alpha(1-3)Galp beta(1-4)G...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Bettler E,Imberty A,Priem B,Chazalet V,Heyraud A,Joziasse DH,Geremia RA

    更新日期:2003-03-14 00:00:00

  • Aminoglycoside antibiotics induce pH-sensitive activation of the calcium-sensing receptor.

    abstract::The aminoglycoside antibiotic (AGA) neomycin is a known agonist of the extracellular calcium-sensing receptor (CaR). To test whether other AGA drugs stimulate the CaR, we studied the relative effects of four AGAs on intracellular Ca(2+) concentration ([Ca(2+)](i)) using CaR-transfected human embryonic kidney (HEK)-293...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: McLarnon S,Holden D,Ward D,Jones M,Elliott A,Riccardi D

    更新日期:2002-09-13 00:00:00

  • Enhancing activity of N-glycosylation for constitutive proteins secretions in non-polarized cells.

    abstract::Several fusion proteins of mouse Interleukins (mILs) and the enhanced green fluorescent protein (EGFP) were expressed in fibroblast and epithelial cells. Among these proteins, the mIL-31 derivative was the most efficiently secreted into the medium in a N-glycosylation-dependent manner. From the analysis of deletion mu...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Akiyama N,Ohno Y,Fukuda T,Manome Y,Saito S

    更新日期:2009-04-17 00:00:00

  • Stability of a potential blood substitute, HbXL99 alpha, under high pressure.

    abstract::One important criteria for a plasma circulating hemoglobin blood substitute is resistance to subunit dissociation. For this reason, cross-linked hemoglobins (with low oxygen affinities) are being specifically designed to serve as potential blood substitutes. An example is HbXL99 alpha, cross-linked between the alpha-s...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Hirsch RE,Friedman JM,Harrington JR,Scarlata SF,Harrington JP

    更新日期:1994-05-16 00:00:00

  • Differences in two mice strains on kainic acid-induced amygdalar seizures.

    abstract::Seizure susceptibility and neurodegeneration induced by microinjection of kainic acid (KA) into the left amygdala (LA) in C57BL/6 and FVB/N mouse strains were compared. Mice were administered 0.5 microg of KA into the LA. Electroencephalograms (EEGs) and behavior were monitored for 48 h after KA microinjection. Neuron...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kasugai M,Akaike K,Imamura S,Matsukubo H,Tojo H,Nakamura M,Tanaka S,Sano A

    更新日期:2007-06-15 00:00:00

  • Position of cyclization in cyclic ADP-ribose.

    abstract::Cyclic adenosine diphosphoribose (cADPR) is a putative second messenger of calcium homeostasis synthesized from NAD by cleavage of the nicotinamide-ribose bond and cyclization of the ribose to the adenine ring. In this study, the ultraviolet absorption spectra of cADPR have been studied as a function of pH and compare...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Kim H,Jacobson EL,Jacobson MK

    更新日期:1993-08-16 00:00:00

  • [8]-Gingerol inhibits melanogenesis in murine melanoma cells through down-regulation of the MAPK and PKA signal pathways.

    abstract::[8]-Gingerol is an active component of Zinger and shows several pharmacological activities, such as antipyretic and anti-inflammation characteristics. To identify a potential skin-whitening agent, the inhibitory effects of [8]-gingerol on melanogenesis and its mechanism of action were investigated. In the present stud...

    journal_title:Biochemical and biophysical research communications

    pub_type: 杂志文章


    authors: Huang HC,Chou YC,Wu CY,Chang TM

    更新日期:2013-08-23 00:00:00