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Mannose 6-phosphate/insulin like growth factor II receptor: the two types of ligands bind simultaneously to one receptor at different sites.

Abstract：

:Pentamannose 6-phosphate/trilysine substituted aprotinin (PMP-lys-aprotinin) and insulin like growth factor II (IGF II) were used as affinity ligands for the mannose 6-phosphate (M6P) and IGF II binding sites of the M6P/IGF II receptor. Both ligands were cross linked to intact receptor and tryptic fragments of the receptor. The pattern of receptor fragments with M6P and IGF II binding sites differed indicating that the two binding sites are located on different segments of the receptor. The receptor was incubated with [125I]IGF II and pentamannose 6-phosphate substituted bovine serum albumin (PMP-BSA). From these mixtures [125I]IGF II receptor complexes could be precipitated with antibodies against the PMP-BSA indicating that the M6P/IGF II receptor can bind simultaneously IGF II and M6P-containing ligands.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Waheed A,Braulke T,Junghans U,von Figura K

doi

10.1016/s0006-291x(88)80419-4

subject

Has Abstract

pub_date

1988-05-16 00:00:00

pages

1248-54

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80419-4

journal_volume

152

pub_type

杂志文章

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