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Dynamic changes in expression of heme oxygenases in mouse heart and liver during hypoxia.

Abstract：

:Heme oxygenase cleaves heme to form biliverdin, carbon monoxide (CO), and iron, and consists of two structurally related isozymes, HO-1 and HO-2. HO-2 is also known as a potential oxygen sensor. Here we show that the relative CO content in arterial blood, which reflects the total amount of endogenous heme degradation, dynamically changes in mice during acclimatization to normobaric hypoxia (10% O2), with the two peaks at 1 day and 21 days of hypoxia. The expression levels of HO-1 and HO-2 proteins were decreased by 20% and 40%, respectively, in the mouse liver at 7 days of hypoxia, which returned to the basal levels at 14 days. On the other hand, HO-1 and HO-2 proteins were increased 2-fold and 1.3-fold, respectively, in the heart at 28 days of hypoxia. Thus, hypoxia induces or represses the expression of HO-1 and HO-2 in vivo, depending on cellular microenvironments.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Han F,Takeda K,Yokoyama S,Ueda H,Shinozawa Y,Furuyama K,Shibahara S

doi

10.1016/j.bbrc.2005.08.100

subject

Has Abstract

pub_date

2005-12-09 00:00:00

pages

653-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)01833-4

journal_volume

338

pub_type

杂志文章

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