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Bone morphogenetic protein-2 down-regulates miR-206 expression by blocking its maturation process.

Abstract：

:MicroRNAs (miRNAs) are small non-coding RNAs that are emerging as important post-transcriptional gene regulators. miR-206 is unique in that it is expressed only in skeletal muscle, including the myoblastic C2C12 cell line. In C2C12 cells, miR-206 expression was reduced dramatically after bone morphogenetic protein (BMP)-2 treatment. The down-regulation of miR-206 expression was also observed after co-transfection with constitutively-active Smad1 and Smad4, which are the intracellular signaling molecules of the BMP pathway. BMP-2 also reduced miR-206 expression in the presence of alpha-amanitin in a similar manner to that in the absence of alpha-amanitin. Moreover, the expression of pri-miR-206 was increased upon BMP-2 treatment for 6h compared to that in the absence of BMP-2. These results suggested that BMP-2 down-regulates miR-206 expression at the post-transcriptional level, by inhibiting the processing of pri-miR-206 into mature miR-206, and that BMP-2 could regulate miRNA biogenesis by a novel mechanism.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sato MM,Nashimoto M,Katagiri T,Yawaka Y,Tamura M

doi

10.1016/j.bbrc.2009.03.142

subject

Has Abstract

pub_date

2009-05-22 00:00:00

pages

125-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)00628-7

journal_volume

383

pub_type

杂志文章

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