Lembehyne A, a spongean polyacetylene, induces neuronal differentiation in neuroblastoma cell.

abstract：:In the assay of glutamate and gamma-aminobutyric acid (GABA) with a high-performance liquid chromatography, spontaneous release of glutamate and GABA from rat hippocampal slices was significantly enhanced by mecamylamine, an inhibitor of non-alpha7 ACh receptors, or alpha-bungarotoxin, an inhibitor of alpha7 ACh recep...

journal_title：Biochemical and biophysical research communications

authors： Kanno T,Yaguchi T,Yamamoto S,Nagata T,Yamamoto H,Fujikawa H,Nishizaki T

更新日期：2005-12-16 00:00:00

abstract：:To investigate the maturation of neonatal erythrocytes and kinetics of globin expression, we induced CD34(+) cells purified from human umbilical cord blood to erythroid differentiation in different suspension culture systems containing human cord serum (CHS) and adult serum (AHS), respectively. The zeta- to alpha-glob...

journal_title：Biochemical and biophysical research communications

authors： Zhang X,Luo YM,Ma YN,Zhang JW

更新日期：2005-10-14 00:00:00

abstract：:Four new basic proteins were isolated from horse eosinophils and purified. The eosinophils release these proteins after permeabilization with saponin and degranulation stimulized by guanosine 5'-O-thiotriphosphate. The proteins were separated and purified on a Superose P12- and a Mono S-column by fast protein liquid c...

journal_title：Biochemical and biophysical research communications

authors： Piller K,Portmann P

更新日期：1993-04-30 00:00:00

abstract：:Dual-excitation ratiometric dyes permit quantitative Ca2+ measurements by minimizing the effects of several artifacts that are unrelated to changes in the concentration of free Ca2+ ([Ca2+]). These dyes are excited alternately at two different wavelengths, and the pair of intensity measurements must be collected seque...

journal_title：Biochemical and biophysical research communications

authors： Fukano T,Shimozono S,Miyawaki A

更新日期：2004-04-23 00:00:00

abstract：:Digestion of discoidin I with several proteolytic enzymes reveals the existence of structural domains in this lectin. Significative differences have been detected in the pattern of fragments generated by V8 protease on discoidin I of various developmental situations. The changes observed can be related to the presence...

journal_title：Biochemical and biophysical research communications

authors： Valencia A,Pestaña A,Cano A

更新日期：1988-05-16 00:00:00

abstract：:Hepatic COX-2 overexpression is sufficient to induce hepatitis, but its role on liver fibrosis remains unknown. We aim to elucidate possible biological effects of COX-2 in liver fibrosis using both gain-of-function and loss-of-function mouse models. COX-2 transgenic (TG) mice that specifically overexpress the human CO...

journal_title：Biochemical and biophysical research communications

authors： Yu J,Wu CW,Chu ES,Hui AY,Cheng AS,Go MY,Ching AK,Chui YL,Chan HL,Sung JJ

更新日期：2008-08-08 00:00:00

abstract：:Platelet adhesion to VLDL, LDL, HDL, and to a mixture of purified apolipoproteins was examined. Platelets adhered to all the classes of lipoproteins tested. VLDL and the apolipoprotein mixture promoted the greatest degree of adhesion. Platelet adhesion was inhibited by addition of EDTA, RGD-containing peptides and ant...

journal_title：Biochemical and biophysical research communications

authors： Kowalska MA,Tuszynski GP,Capuzzi DM

更新日期：1990-10-15 00:00:00

abstract：:We have previously indicated that Xenopus Suppressor of Hairless 2, XSu(H)2, is involved in the morphogenesis of gastrula embryos in a different manner from the XESR-1-mediated Notch signaling pathway. To address the downstream factors of XSu(H)2, we investigated the effect of XSu(H)2 on XenopusPOU-V genes, Xoct25 and...

journal_title：Biochemical and biophysical research communications

authors： Ito M,Nishitani E,Kinoshita T

更新日期：2007-02-16 00:00:00

abstract：:The human cDNA encoding a novel protein serine/threonine kinase most closely related to p70 S6 kinase was isolated from the human erythroleukemia cDNA library and termed p70(S6Kbeta). p70(S6Kbeta) has 67% amino acid identity in overall sequence with human p70(S6K), and the potential phosphorylation sites of p70(S6K) a...

journal_title：Biochemical and biophysical research communications

authors： Saitoh M,ten Dijke P,Miyazono K,Ichijo H

更新日期：1998-12-18 00:00:00

abstract：:Difluoromethylornithine (DFMO) depletes cells of polyamines, sensitizing cells against the action of antineoplastic drugs and altering ability to repair radiation-induced DNA strand breaks. Others have hypothesized that the mechanism by which polyamine depletion sensitizes cells is through inhibition of DNA strand bre...

journal_title：Biochemical and biophysical research communications

authors： Williams JR,Casero RA,Dillehay LE

更新日期：1994-05-30 00:00:00

abstract：:The activation of c-jun N-terminal kinase (JNK) in pancreatic islets is associated with impaired function and viability, and JNK inhibitory peptides (JNKIs) are cytoprotective. In particular, l-isoforms of JNKIs were shown to improve islets viability, while the d-retroinverso isoform of JNKI (RI-JNKI), with a higher t...

journal_title：Biochemical and biophysical research communications

authors： Fornoni A,Cobianchi L,Sanabria NY,Pileggi A,Molano RD,Ichii H,Rosero S,Inverardi L,Ricordi C,Pastori RL

更新日期：2007-03-02 00:00:00

abstract：:Although the first members of the Schlafen gene family were first described almost 10 years ago, the precise molecular/biochemical functions of the proteins they encode still remain largely unknown. Roles in cell growth, haematopoietic cell differentiation, and T cell development/maturation have, with some experimenta...

journal_title：Biochemical and biophysical research communications

authors： Neumann B,Zhao L,Murphy K,Gonda TJ

更新日期：2008-05-23 00:00:00

abstract：:Carp acclimated to 10 degrees C gave 69k, 66k, and 62kDa light meromyosin (LMM) fragments in SDS-PAGE, while fish acclimated to 30 degrees C gave 74k, 69k, 66k, and 62kDa fragments. The microsequence analysis revealed that the 69k and 66kDa components from the 10 degrees C-acclimated carp contained an N-terminal amino...

journal_title：Biochemical and biophysical research communications

authors： Watabe S,Imai J,Nakaya M,Hirayama Y,Okamoto Y,Masaki H,Uozumi T,Hirono I,Aoki T

更新日期：1995-03-08 00:00:00

abstract：:In the presence of 1 mM EGTA, the addition of the calcium ionophore ionomycin to human platelets loaded with 30 microM fura-2 could elevate [Ca2+]i from less than 100 nM to a maximum of greater than 3 microM, presumably by discharge of Ca2+ from internal stores. Under the same conditions thrombin could maximally incre...

journal_title：Biochemical and biophysical research communications

authors： Pollock WK,Rink TJ

更新日期：1986-08-29 00:00:00

abstract：:Apobec1 edits the ApoB mRNA by deaminating nucleotide C(6666), which results in a codon change from Glutamate to stop, and subsequent expression of a truncated protein. Apobec1 is regulated by ACF (Apobec1 complementation factor) and hnRNPQ, which contains an N-terminal "acidic domain" (AcD) of unknown function, three...

journal_title：Biochemical and biophysical research communications

authors： Quaresma AJ,Oyama S Jr,Barbosa JA,Kobarg J

更新日期：2006-11-17 00:00:00

abstract：:A mitosis inhibiting peptide pyroGlu-Glu-Asp-Ser-GlyOH has been isolated from mouse skin extracts. Both the biological and a synthetic peptide with the same structure reversibly inhibit epidermal mitoses in a curvilinear fashion after intraperitoneal injection. The two compounds are chromatographically identical. ...

journal_title：Biochemical and biophysical research communications

authors： Reichelt KL,Elgjo K,Edminson PD

更新日期：1987-08-14 00:00:00

abstract：:Estrogen depletion causes postmenopausal osteoporosis. Here we report that steady state mRNA levels of transforming growth factor-beta 1 (TGF-beta 1) and osteocalcin in bone persistently decreased and increased, respectively, in vivo in estrogen-depleted rats after ovariectomy (OVX). 21 female Wistar rats (7-month-old...

journal_title：Biochemical and biophysical research communications

authors： Ikeda T,Shigeno C,Kasai R,Kohno H,Ohta S,Okumura H,Konishi J,Yamamuro T

更新日期：1993-08-16 00:00:00

abstract：AIM:AF1q has a precise oncogenic function. The purpose of this study is to investigate whether CBD has an effect on the AF1q/ICAM-1 regulatory axis in Burkitt's lymphoma (BL), and thus has potential to enhance immunotherapy and reduce side effects. METHODS:We established BL cell lines with altered AF1q expression usin...

journal_title：Biochemical and biophysical research communications

authors： Togano T,Kim N,Kim N,Park GS,Park AK,Bennet M,Park J

更新日期：2019-11-26 00:00:00

abstract：:We found that PSK has an antiviral effect on human immunodeficiency virus (HIV) in vitro. One of the mechanisms of this effect is attributable to the inhibition of binding of HIV with lymphocytes. Here, we found that PSK inhibits reverse transcriptase in a non-competitive way in vitro. Such inhibition may be important...

journal_title：Biochemical and biophysical research communications

authors： Hirose K,Hakozaki M,Kakuchi J,Matsunaga K,Yoshikumi C,Takahashi M,Tochikura TS,Yamamoto N

更新日期：1987-12-16 00:00:00

abstract：:Auxins regulate various aspects of plant growth and development. However, the mechanism by which these hormones elicit diverse physiological processes is not clear. We present evidence for the role of auxin in protein phosphorylation and the possible involvement of calmodulin in auxin-induced changes. In the presence ...

journal_title：Biochemical and biophysical research communications

authors： Reddy AS,Chengappa S,Poovaiah BW

更新日期：1987-04-29 00:00:00

abstract：:TWIST1, a basic helix-loop-helix transcription factor, plays critical roles in embryo development, cancer metastasis and mesenchymal progenitor differentiation. Little is known about transcriptional regulation of TWIST1 expression. Here we identified DNA sequences responsible for TWIST1 expression in mesenchymal linea...

journal_title：Biochemical and biophysical research communications

authors： Ohkuma M,Funato N,Higashihori N,Murakami M,Ohyama K,Nakamura M

更新日期：2007-01-26 00:00:00

abstract：:This investigation is aimed to determine whether the biosynthesis of H(2)S, an endogenous vasodilator gas, is altered in the streptozotocin-diabetic rat. Plasma H(2)S concentration as well as the activity, and expression, of H(2)S synthesizing enzymes (namely cystathionine-gamma-lyase (CSE) and cystathionine-beta-synt...

journal_title：Biochemical and biophysical research communications

authors： Yusuf M,Kwong Huat BT,Hsu A,Whiteman M,Bhatia M,Moore PK

更新日期：2005-08-12 00:00:00

abstract：:We have previously shown that Hes1 is expressed both in putative epithelial stem cells just above Paneth cells and in the crypt base columnar cells between Paneth cells, while Hes1 is completely absent in Paneth cells. This study was undertaken to clarify the role of Hes1 in Paneth cell differentiation, using Hes1-kno...

journal_title：Biochemical and biophysical research communications

authors： Suzuki K,Fukui H,Kayahara T,Sawada M,Seno H,Hiai H,Kageyama R,Okano H,Chiba T

更新日期：2005-03-04 00:00:00

abstract：:Tat-interactive protein, 60kDa (Tip60) is a histone acetyltransferase with specificity toward lysine 5 of histone H2A (H2AK5) and plays multiple roles in chromatin remodeling processes. Co-immunoprecipitation experiments performed on Jurkat cells, showed that Tip60 is present in the same macro-molecular complex as UHR...

journal_title：Biochemical and biophysical research communications

authors： Achour M,Fuhrmann G,Alhosin M,Rondé P,Chataigneau T,Mousli M,Schini-Kerth VB,Bronner C

更新日期：2009-12-18 00:00:00

abstract：:Site-directed mutagenesis (SDM) of an arylesterase (the arylesterase) from Vibrio mimicus revealed that residues S29, H153, and D96 constituted a catalytic triad. The use of a serine residue for ester hydrolysis by the arylesterase proves that the enzyme is a novel serine arylesterase. SDM also showed that D28 was nec...

journal_title：Biochemical and biophysical research communications

authors： Chang RC,Chen JC,Shaw JF

更新日期：1996-04-16 00:00:00

abstract：:Although D-glucosamine has been reported as an inhibitor of tumor growth both in vivo and in vitro, the mechanism for the anticancer effect of D-glucosamine is still unclear. Since there are several reports suggesting D-glucosamine inhibits protein synthesis, we examined whether D-glucosamine affects p70S6K activity, ...

journal_title：Biochemical and biophysical research communications

authors： Oh HJ,Lee JS,Song DK,Shin DH,Jang BC,Suh SI,Park JW,Suh MH,Baek WK

更新日期：2007-09-07 00:00:00

abstract：:We have recently isolated a neural tissue-specific syntaxin-1-binding protein, named tomosyn, which is capable of dissociating Munc18/n-Sec1/rbSec1 from syntaxin-1 to form a 10S tomosyn complex, an intermediate complex converted to the 7S SNARE complex. We isolated here two splicing variants of tomosyn: one had 36 ami...

journal_title：Biochemical and biophysical research communications

authors： Yokoyama S,Shirataki H,Sakisaka T,Takai Y

更新日期：1999-03-05 00:00:00

abstract：:Upon centrifugation of gently lysed T. cruzi cells through a sucrose gradient, a free DNA fraction was shown to contain catenated dimers and knotted DNA structures. Southern hybridization and electron microscopic studies indicated that both of these structures derived from minicircle DNA, the major component of T. cru...

journal_title：Biochemical and biophysical research communications

authors： Valenzuela MS,Bardhan S,Krishnamani MR,Siddiqui KA

更新日期：1991-01-31 00:00:00

abstract：:The conversion of androgens to estrogens by CYP19 (cytochrome P450AROM, aromatase) is an important step in the mechanism of androgen action in the brain. CYP19 expression has been demonstrated in various animal species, but studies in human postnatal brain tissue are lacking. Therefore, we investigated CYP19 mRNA expr...

journal_title：Biochemical and biophysical research communications

authors： Stoffel-Wagner B,Watzka M,Steckelbroeck S,Schwaab R,Schramm J,Bidlingmaier F,Klingmüller D

更新日期：1998-03-27 00:00:00

abstract：:The existence of cancer stem cells within the tumor could lead to cancer therapy resistance. TGFβ1 is considered as one of the most powerful players in the generation of CSCs through induction of epithelial-mesenchymal transition in different types of cancer including lung cancer, however, the detailed mechanisms by w...

journal_title：Biochemical and biophysical research communications

authors： Zhang F,Li T,Han L,Qin P,Wu Z,Xu B,Gao Q,Song Y

更新日期：2018-02-19 00:00:00