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Three splicing variants of tomosyn and identification of their syntaxin-binding region.

Abstract：

:We have recently isolated a neural tissue-specific syntaxin-1-binding protein, named tomosyn, which is capable of dissociating Munc18/n-Sec1/rbSec1 from syntaxin-1 to form a 10S tomosyn complex, an intermediate complex converted to the 7S SNARE complex. We isolated here two splicing variants of tomosyn: one had 36 amino acids (aa) insertion and another had 17 aa deletion. We named original one m-tomosyn, big one b-tomosyn, and small one s-tomosyn. s-Tomosyn as well as m-tomosyn was mainly expressed in brain whereas b-tomosyn was ubiquitously expressed. All the isoforms bound to syntaxin-1, but not to syntaxin-2, -3, or -4, and had a region highly homologous to VAMP, another syntaxin-binding protein. This region was necessary but not sufficient for high-affinity binding of tomosyn to syntaxin-1.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yokoyama S,Shirataki H,Sakisaka T,Takai Y

doi

10.1006/bbrc.1999.0300

subject

Has Abstract

pub_date

1999-03-05 00:00:00

pages

218-22

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(99)90300-5

journal_volume

256

pub_type

杂志文章

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