Physical association of Ras and cathepsins B and L in the conditioned medium of v-Ha-ras-transformed NIH3T3 cells.

Abstract:

:Immunoblot analysis of the conditioned medium of v-Ha-ras-transformed NIH3T3 cells showed that Ras protein is secreted in the culture fluid. Because cathepsins L and B whose activities are inhibited by Ras are also secreted, possible association between Ras and cathepsins was investigated by immunoprecipitation and following immunoblot analysis. The results showed that Ras is physically associated with cathepsins B and L in the culture fluid.

authors

Hiwasa T,Kominami E

doi

10.1006/bbrc.1995.2696

subject

Has Abstract

pub_date

1995-11-22 00:00:00

pages

828-34

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006291X85726964

journal_volume

216

pub_type

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