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Changes in ornithine transcarbamylase activity and protein level during perinatal period in rat liver. Effects of actinomycin D.

Abstract：

:Ornithine transcarbamylase activity and immunoreactive enzyme level are compared during perinatal period and in adult rat. Ornithine transcarbamylase activity regularly rises during late fetal period and presents a marked increase 24 hours after birth. Immunoreactive enzyme level does not correlate with this developmental pattern. Ornithine transcarbamylase level increases from 0.06 mg on day 19.5 of pregnancy to 0.417 mg/g liver on day 21.5 and remains constant after birth (0.418 mg/g liver). These results suggest that inactive mitochondrial ornithine transcarbamylase accumulates before birth and that the postnatal increase in enzyme activity is mainly associated with an activation. Furthermore, the paradoxical effect of actinomycin D on ornithine transcarbamylase activity is associated with an increase in enzyme level (about 25%).

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Belbekouche M,Gautier C,Vaillant R

doi

10.1016/0006-291x(85)91960-6

subject

Has Abstract

pub_date

1985-06-28 00:00:00

pages

780-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(85)91960-6

journal_volume

129

pub_type

杂志文章

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