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Immunoreactive growth hormone (GH) secretion by human lymphocytes: augmented release by exogenous GH.

Abstract：

:Peripheral blood mononuclear cells (PBMCs) from normal adults secreted small amounts of human growth hormone (GH; 0.2-0.6 pg/10(5) cells/7 days culture) as measured by a highly sensitive enzyme immunoassay. Stimulation of PBMCs with phytohemagglutinin (PHA) consistently showed a 4-6 fold increase in GH secretion. Transformed B-lymphocytes by Epstein-Barr virus also secreted GH (0.8-4.8 pg/5 x 10(4) cells/7 days culture). GH secreted by lymphocytes comigrated with pituitary GH on an Ultrogel AcA44 column. Addition of GH during the culture augmented endogenous GH secretion from PHA-stimulated PBMCs. GH-releasing hormone and a somatostatin analogue, SMS 201-995, did not affect GH secretion from non-stimulated and PHA-stimulated PBMCs. These findings suggest that both T and B lymphocytes secrete immunoreactive GH in a different manner from that in the anterior pituitary.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hattori N,Shimatsu A,Sugita M,Kumagai S,Imura H

doi

10.1016/0006-291x(90)92334-v

subject

Has Abstract

pub_date

1990-04-30 00:00:00

pages

396-401

issue

2

eissn

0006-291X

issn

1090-2104

pii

0006-291X(90)92334-V

journal_volume

168

pub_type

杂志文章

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