Specific binding of phorbol esters to nuclei of human promyelocytic leukemia cells.

abstract：:TREK1 is a member of the tandem-P domain K+ channel family which is expressed almost exclusively in the nervous system. It is modulated by a number of important factors including arachidonic acid and cell swelling. Since both factors are associated with brain ischemia, it has been suggested that activation of TREK1 ma...

journal_title：Biochemical and biophysical research communications

authors： Miller P,Kemp PJ,Peers C

更新日期：2005-06-17 00:00:00

abstract：:The second leader exon and the relative promoter of the mouse liver/bone/kidney-type alkaline phosphatase gene were identified and characterized. The transcription initiation site was determined by S1 mapping analysis. The differential expression of the two alternatively spliced transcripts was assessed in cell lines ...

journal_title：Biochemical and biophysical research communications

authors： Studer M,Terao M,Gianni M,Garattini E

更新日期：1991-09-30 00:00:00

abstract：:In this study, we use HRMAS NMR as a non-invasive technique to monitor the in vivo metabolism of a xenobiotic. The antituberculosis Ethionamide is a pro-drug that has to be activated in mycobacteria before inhibiting its cellular target. The use of (1)H HRMAS NMR has allowed to detect a metabolite (ETH*) of the drug d...

journal_title：Biochemical and biophysical research communications

authors： Hanoulle X,Wieruszeski JM,Rousselot-Pailley P,Landrieu I,Baulard AR,Lippens G

更新日期：2005-06-03 00:00:00

abstract：:Osteoarthritis (OA) is the most common form of joint disease. The development of inflammation have been considered to play a key role during the progression of OA. Regulatory pathways are known to play crucial roles in many pathogenic processes. Thus, deciphering these risk regulatory pathways is critical for elucidat...

journal_title：Biochemical and biophysical research communications

authors： Song Z,Zhang C,He L,Sui Y,Lin X,Pan J

更新日期：2018-06-12 00:00:00

abstract：:In this study, we assessed the profile of cell proliferation, Na,K-ATPase activity and apoptosis in primary cultures of proximal tubule cells. Freshly isolated proximal tubules exhibited apoptosis very early in culture: floated cells within 6 hr; attached tubule cells within 20 hr. The onset of apoptosis in either att...

journal_title：Biochemical and biophysical research communications

authors： Tang MJ,Cheng YR,Lin HH

更新日期：1996-01-26 00:00:00

abstract：:The ras family of oncogenes, as well as the transplasma membrane electron transport system, have been implicated in cellular growth control. Here we present evidence that the Ha-ras oncoprotein increases the activity of the transplasma membrane electron transport system in the mouse embryonic fibroblast cell line C3H1...

journal_title：Biochemical and biophysical research communications

authors： Crowe RA,Taparowsky EJ,Crane FL

更新日期：1993-10-29 00:00:00

abstract：:We established a simple and highly efficient method for in vivo gene transfer using HVJ (Sendai virus) and liposomes. Plasmid DNA and high mobility group 1 (HMG1) protein were co-encapsulated in liposomes by agitation and sonication and were co-introduced into cells by HVJ-mediated membrane fusion. pACT SVT DNA, as a ...

journal_title：Biochemical and biophysical research communications

authors： Tomita N,Higaki J,Morishita R,Kato K,Mikami H,Kaneda Y,Ogihara T

更新日期：1992-07-15 00:00:00

abstract：:FKBP59-HBI, a heat shock protein hsp90-binding immunophilin that was originally detected in heterooligomer forms of steroid receptors, is retained on Calmodulin (CAM)-Sepharose 4B in the presence of 2 mM Ca2+ and is eluted by EGTA, demonstrating a specific p59-CAM interaction. The p59 amino acid sequence reveals the p...

journal_title：Biochemical and biophysical research communications

authors： Massol N,Lebeau MC,Renoir JM,Faber LE,Baulieu EE

更新日期：1992-09-30 00:00:00

abstract：:Long noncoding RNA (lncRNAs) UCA1 has been known to be critical for the chondrogenic differentiation of marrow mesenchymal stem cells (MSCs). In this study, we explore the effects and mechanisms of UCA1 on the promotion of chondrogenesis of MSCs. During the processes of chondrogenic differentiation of MSCs, UCA1, miRN...

journal_title：Biochemical and biophysical research communications

authors： Shu T,He L,Wang X,Pang M,Yang B,Feng F,Wu Z,Liu C,Zhang S,Liu B,Wang Q,Rong L

更新日期：2019-06-18 00:00:00

abstract：:Neuregulin1 (NRG1) is a growth factor that signals through the interaction of the epidermal growth factor (EGF)-like domain with ErbB receptors. An immunoglobulin (Ig)-like domain is contained together with EGF-like domain in the ectodomain of some isoforms generated by alternative splicing, but its role in NRG1 signa...

journal_title：Biochemical and biophysical research communications

authors： Eto K,Eda K,Kanemoto S,Abe S

更新日期：2006-11-17 00:00:00

abstract：BACKGROUND:Mutations in the four and-a-half LIM domain protein 1 (FHL1) gene or FHL1 protein deletion have been identified as the cause of rare hereditary myopathies or cardiomyopathies. In our previous study, autophagy activation was associated with myofibrillar abnormalities in FHL1 knockout (KO) mice. P2RX7 induces ...

journal_title：Biochemical and biophysical research communications

authors： Ding J,Cong Y,Li F,Liu B,Wu D,Miao J,Wang L

更新日期：2020-02-26 00:00:00

abstract：:Phospholipids are distributed asymmetrically in the plasma membrane (PM) of mammalian cells. Phosphatidylinositol (PI) and its phosphorylated forms are primarily located in the inner leaflet of the PM. Among them, phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a well-known substrate for phospholipase C (PLC) or ...

journal_title：Biochemical and biophysical research communications

authors： Yoneda A,Kanemaru K,Matsubara A,Takai E,Shimozawa M,Satow R,Yamaguchi H,Nakamura Y,Fukami K

更新日期：2020-07-05 00:00:00

abstract：:Dysregulation of the receptor tyrosine kinase Axl and its ligand Gas6 has been shown to promote multiple tumorigenic processes, as well as to correlate with worse prognosis in many different tumor types. However, studies of Axl expression and function in osteosarcoma have rarely been reported. In this study, we report...

journal_title：Biochemical and biophysical research communications

authors： Han J,Tian R,Yong B,Luo C,Tan P,Shen J,Peng T

更新日期：2013-06-07 00:00:00

abstract：:Small heat-shock proteins (sHSPs) represent an abundant and ubiquitous family of molecular chaperones. The current model proposes that sHSPs function to prevent irreversible aggregation of non-native proteins by forming soluble complex. The chaperone activity of sHSPs is usually determined by the capacity to suppress ...

journal_title：Biochemical and biophysical research communications

authors： Jiao W,Li P,Zhang J,Zhang H,Chang Z

更新日期：2005-09-16 00:00:00

abstract：:The effects of cAMP on the expression of ETA (ET-1 selective type) receptor mRNA and on the response to endothelin-1 (ET-1) were investigated in rat aortic smooth muscle cells in primary culture, using reverse transcription polymerase chain reaction (RT-PCR) and fura-2 microfluorometry of cytosolic Ca2+ concentrations...

journal_title：Biochemical and biophysical research communications

authors： Nishimura J,Chen X,Jahan H,Shikasho T,Kobayashi S,Kanaide H

更新日期：1992-10-30 00:00:00

abstract：:Asialofetuin-tacked liposomes (AF-liposomes) encapsulating interferon (IFN)-gamma were bound and internalized into a human hepatoma cell line, HepG2 cells, selectively through asialoglycoprotein receptor, but not non-tacked liposomes (N-liposomes). AF-liposomal IFN-gamma was more effective for inhibition of viral DNA ...

journal_title：Biochemical and biophysical research communications

authors： Ishihara H,Hayashi Y,Hara T,Aramaki Y,Tsuchiya S,Koike K

更新日期：1991-01-31 00:00:00

abstract：:Angiotensin II (Ang II) and oxidized LDL (Ox-LDL) are risk factors for atherosclerosis, and both of them contribute to macrophage cholesterol accumulation, the hallmark of early atherosclerosis. As Ang II was shown to increase macrophage uptake of Ox-LDL, we investigated the effect of losartan, an Ang II receptor anta...

journal_title：Biochemical and biophysical research communications

authors： Hayek T,Aviram M,Heinrich R,Sakhnini E,Keidar S

更新日期：2000-07-05 00:00:00

abstract：:Microinjection of purified transcriptionally active ribonucleoprotein (RNP) complex of vesicular stomatitis virus in vero cells resulted in the production and release of virus. Compared to the release of virus by cells treated with RNP in the presence of DEAE-dextran, the microinjection technique was highly efficient....

journal_title：Biochemical and biophysical research communications

authors： Thornton GB,Kopchick JJ,Stacey DW,Banerjee AK

更新日期：1983-11-15 00:00:00

abstract：:Human platelets are less responsive to PAF at 37 degrees than at 25 degrees. They can be desensitized to the effects of PAF by pre-exposure to small concentrations. In both cases desensitization appears to be accompanied by a decreased affinity of the high affinity site for PAF rather than loss of binding sites. Alter...

journal_title：Biochemical and biophysical research communications

authors： Chesney CM,Pifer DD,Huch KM

更新日期：1985-02-28 00:00:00

abstract：:3q21q26 syndrome, an acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) with chromosomal translocations or inversions between the bands 3q21 and 3q26, is frequently associated with dysmegakaryocytopoiesis and increased platelet counts at the initial diagnosis. Since the EVI1 gene at 3q26 is transcriptional...

journal_title：Biochemical and biophysical research communications

authors： Shimizu S,Nagasawa T,Katoh O,Komatsu N,Yokota J,Morishita K

更新日期：2002-04-05 00:00:00

abstract：:The structure of human carbonic anhydrase II at pH 9.5 has been studied by X-ray crystallographic methods to 2.2 A resolution. These studies complement those performed under acidic conditions in which the catalytically-important proton-shuttle group, His-64, exhibits conformational mobility about side-chain torsion an...

journal_title：Biochemical and biophysical research communications

authors： Nair SK,Christianson DW

更新日期：1991-12-16 00:00:00

abstract：:The specificity of the endoglycanase associated with the bacteriophage phi SK1 particles was tested on the native capsular polysaccharide produced by Klebsiella pneumoniae serotype SK1 and on three chemically modified polymers derived from it. The primary structure of the SK1 capsular polysaccharide is: [formula: see ...

journal_title：Biochemical and biophysical research communications

authors： Cescutti P,Paoletti S

更新日期：1994-02-15 00:00:00

abstract：:The effect of calcitonin gene-related peptide(CGRP) on the release of atrial natriuretic peptide(ANP) was studied in spontaneously beating, isolated rat atria. CGRP stimulated the ANP release in a dose-dependent manner. When the atria were incubated with a combination of phentolamine, propranolol, and atropine, these ...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto A,Kimura S,Hasui K,Fujisawa Y,Tamaki T,Fukui K,Iwao H,Abe Y

更新日期：1988-09-30 00:00:00

abstract：:Bradykinin (BK) B2 receptor signaling involves activation of phospholipase C (PLC). PLC activation by other receptors consists of either allosteric activation of PLC beta isoforms by G-proteins or tyrosine phosphorylation of PLC gamma isoforms. Because the B2 receptor is a G-protein-coupled receptor, it has been assum...

journal_title：Biochemical and biophysical research communications

authors： Venema VJ,Ju H,Sun J,Eaton DC,Marrero MB,Venema RC

更新日期：1998-05-08 00:00:00

abstract：:We have recently observed that attomolar concentration of exogenously added TGF beta, a molecule structurally related to inhibin, can stimulate the basal secretion of FSH in a pituitary cell culture. Inhibin purified from porcine follicular fluid antagonizes this activity of TGF beta. To understand further the homeost...

journal_title：Biochemical and biophysical research communications

authors： Ying SY,Becker A,Ling N,Ueno N,Guillemin R

更新日期：1986-05-14 00:00:00

abstract：:Although compelling data have demonstrated the effectiveness of estrogen replacement therapy for the treatment of accelerated bone loss in postmenopausal osteoporosis and ovariectomized animals, the mechanisms by which estrogens reduce bone resorption remain to be elucidated. To address this issue, in the present stud...

journal_title：Biochemical and biophysical research communications

authors： Zecchi-Orlandini S,Formigli L,Tani A,Benvenuti S,Fiorelli G,Papucci L,Capaccioli S,Orlandini GE,Brandi ML

更新日期：1999-02-24 00:00:00

abstract：:Treatment of the cells of the 311 cell line, a pluripotent mouse teratocarcinoma cell line, with 12-O-tetradecanoylphorbol-13-acetate (TPA) modulates c-mos expression. Transient suppression of 6.1 and 4.6 kilobases (kb) transcripts and activation of 1.8 transcript indicate that TPA mediates concurrently positive and n...

journal_title：Biochemical and biophysical research communications

authors： Ogiso Y,Kitagawa K,Nishino H,Iwashima A

更新日期：1988-07-15 00:00:00

abstract：:Zinc ribbon domain-containing 1 (ZNRD1), a transcription-associated gene, was recently found to be downregulated in human gastric cancer tissues as compared to the matched adjacent nonneoplastic tissues. In this study, we constructed the siRNA eukaryotic expression vectors of ZNRD1 and transfected them into normal gas...

journal_title：Biochemical and biophysical research communications

authors： Hong L,Zhang Y,Liu N,Liu C,Zhi M,Pan Y,Lan M,Sun L,Fan D

更新日期：2004-08-27 00:00:00

abstract：:Rab7, a member of the Rab family small G proteins, is involved in the late stage of the endocytic pathway. We previously identified a Rab7 target protein, Rabring7, which contains a RING finger domain at its C termini, but the precise role of Rabring7 remains unknown. In this study, we demonstrate using an in vitro ub...

journal_title：Biochemical and biophysical research communications

authors： Sakane A,Hatakeyama S,Sasaki T

更新日期：2007-06-15 00:00:00

abstract：:GMP-140 (CD62; PADGEM) is a member of the selectin family expressed highly at the surface of platelets and endothelial cells by agonists such as thrombin or phorbol esters. Previous studies indicate that the lectin domain of GMP-140 recognizes sialosyl-Le(x) (SLex) and to a lesser extent Le(x) (Polley MJ, et al., Proc...

journal_title：Biochemical and biophysical research communications

authors： Handa K,Nudelman ED,Stroud MR,Shiozawa T,Hakomori S

更新日期：1991-12-31 00:00:00