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Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene.

Abstract：

:Zinc ribbon domain-containing 1 (ZNRD1), a transcription-associated gene, was recently found to be downregulated in human gastric cancer tissues as compared to the matched adjacent nonneoplastic tissues. In this study, we constructed the siRNA eukaryotic expression vectors of ZNRD1 and transfected them into normal gastric epithelial cells (GES-1). We also introduced the ZNRD1 gene into gastric cancer cells that do (SGC7901) and do not (AGS) express ZNRD1 endogenously. GES-1 cells stably transfected with the ZNRD1-RNAi were found to exhibit significantly quicker proliferation than empty vector transfectants. AGS cells stably transfected with the ZNRD1 cDNA exhibited significantly decreased growth rate as compared to control vector transfectants, whereas SGC7901 cells did not. Furthermore, ZNRD1 suppresses growth of AGS cells in soft agar and tumor formation in athymic nude mice. This study clearly demonstrates that ZNRD1 may play an important role in the control of human gastric cancer development by regulating cell proliferation. These results provide new insights into the function of ZNRD1 and further validate ZNRD1 as a potential therapeutic target in gastric cancer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hong L,Zhang Y,Liu N,Liu C,Zhi M,Pan Y,Lan M,Sun L,Fan D

doi

10.1016/j.bbrc.2004.07.007

subject

Has Abstract

pub_date

2004-08-27 00:00:00

pages

611-6

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(04)01479-2

journal_volume

321

pub_type

杂志文章

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