Isolation of a cDNA clone for the alpha subunit of the human GABA-A receptor.

abstract：:Rett syndrome is a neurodevelopmental disorder caused by Mecp2 gene mutations. In RTT patients and Mecp2-null (Mecp2(-/Y)) mice, norepinephrine (NE) content drops significantly, which may play a role in breathing arrhythmia, sleep disorders and sudden death. However, the underlying mechanisms for the NE defect are not...

journal_title：Biochemical and biophysical research communications

authors： Zhang X,Su J,Rojas A,Jiang C

更新日期：2010-04-02 00:00:00

abstract：:Hepatocyte growth factor/scatter factor (HGF) is a multifunctional growth factor that is linked to the initiation and/or progression of numerous malignancies. HGF also alters cancer cell responses to DNA damaging cytotoxic agents. Many cell responses to Met activation require alterations in metabolic activity but how ...

journal_title：Biochemical and biophysical research communications

authors： Xia S,Laterra J

更新日期：2006-07-14 00:00:00

abstract：:SIRT2 is a member of the sirtuin family of NAD(+)-dependent protein deacetylases. It is involved in metabolic homeostasis and has been linked to the progression of age-related diseases. Casitas B-lineage lymphoma (Cbl) proteins regulate signal transduction through many pathways and, consequently, regulate cell functio...

journal_title：Biochemical and biophysical research communications

authors： Choi YH,Kim H,Han Y,Jin YH,Lee KY

更新日期：2014-10-24 00:00:00

abstract：:Fibrosis is an abnormal response to organ injury, characterized by accumulation of activated fibroblasts at the sites of injury. Fibroblasts arise from several sources, including resident fibroblasts and circulating fibrocytes that infiltrate organ tissue. Recently, epithelial-mesenchymal transition (EMT) has been rec...

journal_title：Biochemical and biophysical research communications

authors： Mikami Y,Yamauchi Y,Horie M,Kase M,Jo T,Takizawa H,Kohyama T,Nagase T

更新日期：2012-11-30 00:00:00

abstract：:Carbachol stimulated inositol trisphosphate (IP3) production and subsequent calcium mobilization in parotid cells are almost completely inhibited by neomycin. In contrast epinephrine stimulated IP3 production and calcium mobilization are much less sensitive to such inhibition. Since neomycin exerts its effects primari...

journal_title：Biochemical and biophysical research communications

authors： Kowatch MA,Roth GS

更新日期：1989-07-14 00:00:00

abstract：:Endothelin (ET)-related peptides including ET-1 (1-39) were synthesized, and their constricting activity in rat pulmonary artery rings and pressor activity in unanesthetized rat were measured to elucidate their structure-activity relationship. The vasoconstrictor activities of ET-2, ET-3 and sarafotoxin S6b were one-h...

journal_title：Biochemical and biophysical research communications

authors： Nakajima K,Kubo S,Kumagaye S,Nishio H,Tsunemi M,Inui T,Kuroda H,Chino N,Watanabe TX,Kimura T

更新日期：1989-08-30 00:00:00

abstract：:Oligodendrocytes (OLGs) are cells from the central nervous system that synthesize, assemble, and maintain myelin, the multilamellar membrane that surrounds axons and facilitates the fast conduction of nerve impulses. We have shown that OLGs initiate their myelinogenic phenotype upon adhesion to GRASP, a heparin-bindin...

journal_title：Biochemical and biophysical research communications

authors： Szuchet S,Plachetzki DC,Eaton KS

更新日期：2001-05-18 00:00:00

abstract：:Bone morphogenetic protein7 (BMP7) attenuates renal tubular and interstitial damage in a variety of experimental models. The function of BMP in the glomerulus is, however, not well understood. In the present study, we generated transgenic mice carrying cDNA for noggin, an endogenous inhibitor of BMPs, driven by the po...

journal_title：Biochemical and biophysical research communications

authors： Miyazaki Y,Ueda H,Yokoo T,Utsunomiya Y,Kawamura T,Matsusaka T,Ichikawa I,Hosoya T

更新日期：2006-02-10 00:00:00

abstract：:Estrogen is known to play a pivotal role in granulosa cell responses to follicle-stimulating hormone (FSH) that is critical for the establishment of dominant follicles and subsequent ovulation in mammals. Thus, elucidating the cellular and molecular mechanisms that regulate FSH activity is important to understand fema...

journal_title：Biochemical and biophysical research communications

authors： Miyoshi T,Otsuka F,Shimasaki S

更新日期：2013-05-03 00:00:00

abstract：:Recombination in a bovine papillomavirus shuttle vector carrying direct repeats of Moloney murine leukemia virus LTR sequence was examined. Differently from similar vectors carrying direct repeats of SV40 polyA addition signal or neomycin resistance gene, the vector exhibited no homologous recombination between the re...

journal_title：Biochemical and biophysical research communications

authors： Kitamura Y,Naito A,Yoshikura H

更新日期：1991-08-30 00:00:00

abstract：:Oligo/poly alpha2,8 deaminoneuraminic acid (KDN), a unique posttranslational protein modification, was found on megalin and a not yet characterized 150 kDa glycoprotein. We purified this glycoprotein from rat testis and identified it as ceruloplasmin. Furthermore, immunoprecipitated ceruloplasmin from rat thymus, ovar...

journal_title：Biochemical and biophysical research communications

authors： Ziak M,Meier M,Novak-Hofer I,Roth J

更新日期：2002-07-19 00:00:00

abstract：:The transcription of human nm23 genes (nm23-H1, nm23-H2) is involved in suppression of tumor metastasis or tumor progression. Therefore the characterization of transcriptional regulatory mechanisms for both nm23 genes is very important. In this study we have isolated and analyzed the 5'-flanking region of the human nm...

journal_title：Biochemical and biophysical research communications

authors： Seifert M,Seib T,Engel M,Dooley S,Welter C

更新日期：1995-10-24 00:00:00

abstract：:Significant attention has been given to the role played by non-hematopoietic cells in the immune organs, including the lymph nodes, in hopes of understanding the development, maintenance, and regulation of the immune system. However, the molecular and cellular characterization of non-hematopoietic cells is still in it...

journal_title：Biochemical and biophysical research communications

authors： Togoo K,Takahama Y,Takada K

更新日期：2014-06-27 00:00:00

abstract：:The bacterial superantigen staphylococcal enterotoxin A (SEA) is a potent inducer of CTL activity and cytokine production in vivo. Protein A (PA) of Staphylococcal aureus has been found to have diverse biological response modifying properties and to possess antitumor, antitoxic and antiparasitic effects. In this study...

journal_title：Biochemical and biophysical research communications

authors： Mondal TK,Bhatta D,Biswas S,Pal P

更新日期：2002-02-01 00:00:00

abstract：:Complementary DNA corresponding to total poly(A)+-RNA from the human A431 epidermoid carcinoma cell line was cloned in the phage expression vector lambda gt 11. An epidermal growth factor (EGF) receptor cDNA clone was obtained by screening of the expression library with a rabbit polyclonal antibody (IgG), raised to th...

journal_title：Biochemical and biophysical research communications

authors： Simmen FA,Gope ML,Schulz TZ,Wright DA,Carpenter G,O'Malley BW

更新日期：1984-10-15 00:00:00

abstract：:The emergence of new molecular targeting agents has improved the prognosis of patients with multiple myeloma (MM). However, MM remains incurable because MM stem cells are likely resistant to these agents. Thus, it is important to further investigate the biology of MM stem cells, which reside in the hypoxic bone marrow...

journal_title：Biochemical and biophysical research communications

authors： Nakagawa Y,Ashihara E,Yao H,Yokota A,Toda Y,Miura Y,Nakata S,Hirai H,Maekawa T

更新日期：2018-02-05 00:00:00

abstract：:The telomere-associated protein tankyrase 1 is a poly(ADP-ribose) polymerase and is considered to be a promising target for cancer therapy, especially for BRCA-associated cancers. However, an efficient assay system for inhibitor screening has not been established, mainly due to the difficulty of efficient preparation ...

journal_title：Biochemical and biophysical research communications

authors： Yashiroda Y,Okamoto R,Hatsugai K,Takemoto Y,Goshima N,Saito T,Hamamoto M,Sugimoto Y,Osada H,Seimiya H,Yoshida M

更新日期：2010-04-09 00:00:00

abstract：INTRODUCTION:Multiple myeloma (MM) remains incurable due to high rates of relapse after various treatment regimens. WEE1 is a cell cycle related gene that regulates the G2/M checkpoint and promotes cell cycle suspension for consequent DNA repair. To date, there are clinical studies for the evaluation of WEE1 inhibitors...

journal_title：Biochemical and biophysical research communications

authors： Barbosa RSS,Dantonio PM,Guimarães T,de Oliveira MB,Fook Alves VL,Sandes AF,Fernando RC,Colleoni GWB

更新日期：2019-11-12 00:00:00

abstract：:The proB proA operons (which are blocked by the feedback inhibition of proline production) of Escherichia coli wild type or with the mutation proBosm, blocking feedback inhibition effect of proline production, were cloned in a broad host range shuttle vector pVA 12-2. The hybrid plasmids pLVA(proB+A+) and pNSA(proBosm...

journal_title：Biochemical and biophysical research communications

authors： Neumivakin LV,Solovjev VP,Sokhansanj A,Tilba VA,Moseiko NA,Shachbasian RV,Piruzian ES

更新日期：1995-12-26 00:00:00

abstract：:Infrared spectra of E. coli strain JM103 and transformants which overproduced recombinant proinsulin have been measured as a function of pressure up to 38 kbar. It is the first time that high-pressure infrared spectra of live bacteria have been successfully measured. In ambient conditions, spectra of the host strain J...

journal_title：Biochemical and biophysical research communications

authors： Wong PT,Zahab DM,Narang SA,Sung WL

更新日期：1987-07-15 00:00:00

abstract：:One of the most important issues in stem cell research is to understand the regulatory mechanisms responsible for their differentiation. An extensive understanding of mechanism underlying the process of differentiation is crucial in order to prompt stem cells to perform a particular function after differentiation. To ...

journal_title：Biochemical and biophysical research communications

authors： Feng Z,Srivastava AS,Mishra R,Carrier E

更新日期：2004-11-26 00:00:00

abstract：:COMPARE computer program suggested that benzamide riboside, BR, 3-(1-deoxy-beta-D-ribofuranosyl)benzamide, should have a similar mechanism of action as that of tiazofurin, an inhibitor of IMP dehydrogenase (IMPDH). This hypothesis was tested in K562 cells in culture. BR was cytotoxic to K562 cells with an IC50 of 2 mi...

journal_title：Biochemical and biophysical research communications

authors： Jayaram HN,Gharehbaghi K,Jayaram NH,Rieser J,Krohn K,Paull KD

更新日期：1992-08-14 00:00:00

abstract：:Rat molars and incisors have different root patterning mechanisms: the former form a multirooted pattern while the latter form a single-rooted analogue. But the genetic signals that control root patterning are poorly understood. In this study, to identify the special molecular signals which may lead to the molar root ...

journal_title：Biochemical and biophysical research communications

authors： Xing X,Deng Z,Yang F,Watanabe S,Wen L,Jin Y

更新日期：2007-11-30 00:00:00

abstract：:Recombinant baculoviruses expressing full length and 3' truncated forms of c-DNA encoding the Drosophila melanogaster acetylcholinesterase (AChE) were constructed. Biochemical analyses showed that full length recombinant protein was enzymatically active and anchored to the cell membrane via a glycolipidic residue. DTT...

journal_title：Biochemical and biophysical research communications

authors： Chaabihi H,Fournier D,Fedon Y,Bossy JP,Ravallec M,Devauchelle G,Cérutti M

更新日期：1994-08-30 00:00:00

abstract：:Although many advances have been made in the treatment of gastric cancer (GC), numerous difficulties, such as the emergence of chemo-drug resistance, continue to lead to disappointing GC prognoses. Thus, novel alternative strategies are urgently needed. The use of natural products could be a viable option to treat GC....

journal_title：Biochemical and biophysical research communications

authors： Zhou Q,Wu X,Wen C,Wang H,Wang H,Liu H,Peng J

更新日期：2018-10-20 00:00:00

abstract：:The loss of paramagnetism of the stable free radical 4,4'-di-tert.-butyl- diphenyl-1-nitroxy during illumination of the photosensitizer meso-tetrahydroxyphenyl chlorine by light above 620 nm in the absence of oxygen has been followed by kinetic ESR spectroscopy. Addition of the spin trap alpha-(4-pyridyl-1-oxide)- N-t...

journal_title：Biochemical and biophysical research communications

authors： Kriska T,Korecz L,Nemes I,Gál D

更新日期：1995-10-04 00:00:00

abstract：:Secreted by tumor and stromal cells, S100 proteins exert their biological functions via the interaction with surface receptors. The most described receptor is the receptor for advanced glycation end-products (RAGE), thereby participating in the S100-dependent cell migration, invasion, tumor growth, angiogenesis and me...

journal_title：Biochemical and biophysical research communications

authors： Padilla L,Dakhel S,Hernández JL

更新日期：2014-03-28 00:00:00

abstract：BACKGROUND/AIMS:We have previously reported that the application of sphingomyelin-based liposomes (SM-L) to a three-dimensional cultured skin model increase the content of ceramides NS, NP, AS and AP. However, the mechanism responsible for these increased ceramide levels was not identified. METHODS:SM-L and sphingomye...

journal_title：Biochemical and biophysical research communications

authors： Itaya Y,Tokudome Y

更新日期：2016-04-22 00:00:00

abstract：:The physiologically active form of vitamin D, 1,25-dihydroxyvitamin D(3), plays an important role not only in the establishment and maintenance of calcium metabolism, but also in regulating cell growth and differentiation. Because the clinical usefulness of 1,25-dihydroxyvitamin D(3) is limited by its tendency to caus...

journal_title：Biochemical and biophysical research communications

authors： Gaschott T,Steinmeyer A,Steinhilber D,Stein J

更新日期：2002-01-11 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has the ability to selectively trigger cancer cell apoptosis and can be used as a target for tumor therapy. However, gastric cancer cells are usually insensitive to TRAIL so reducing this drug resistance may improve the treatment of gastric cancer. In thi...

journal_title：Biochemical and biophysical research communications

authors： Li H,Lv J,Guo J,Wang S,Liu S,Ma Y,Liang Z,Wang Y,Qi W,Qiu W

更新日期：2021-01-18 00:00:00