当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Toosendanin induces caspase-dependent apoptosis through the p38 MAPK pathway in human gastric cancer cells.

Toosendanin induces caspase-dependent apoptosis through the p38 MAPK pathway in human gastric cancer cells.

Abstract：

:Although many advances have been made in the treatment of gastric cancer (GC), numerous difficulties, such as the emergence of chemo-drug resistance, continue to lead to disappointing GC prognoses. Thus, novel alternative strategies are urgently needed. The use of natural products could be a viable option to treat GC. Toosendanin (TSN) is a triterpenoid derived from the bark of Melia toosendanin Sieb. et Zucc that has been shown to be highly cytotoxic to multiple cancer cells. As the underlying impact of TSN on GC and its molecular mechanism remain poorly understood, in this study, we performed a series of experiments involving the use of TSN to treat GC cells. In the present study, we showed that TSN suppressed cell viability, inhibited cell proliferation by causing G1/S arrest and induced caspase-dependent apoptosis in AGS and HGC-27 cells. The possible mechanism of TSN-induced apoptosis may be associated with the activation of the p38 MAPK pathway. These results demonstrated the potential of TSN as a promising therapeutic compound to treat gastric cancer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Zhou Q,Wu X,Wen C,Wang H,Wang H,Liu H,Peng J

doi

10.1016/j.bbrc.2018.09.093

subject

Has Abstract

pub_date

2018-10-20 00:00:00

pages

261-266

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)32018-7

journal_volume

505

pub_type

杂志文章

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