ZK 156718, a low calcemic, antiproliferative, and prodifferentiating vitamin D analog.

abstract：:Small ubiquitin-like modifiers (SUMOs) are proteins homologous to ubiquitin that possibly regulate intranuclear protein localization, nuclear transport, and ubiquitination. We examined patients of DRPLA, SCA1, MJD, and Huntington's disease and found that neurons in affected regions of the brain react strongly to SUMO-...

journal_title：Biochemical and biophysical research communications

authors： Ueda H,Goto J,Hashida H,Lin X,Oyanagi K,Kawano H,Zoghbi HY,Kanazawa I,Okazawa H

更新日期：2002-04-26 00:00:00

abstract：:Amyloid beta precursor protein (APP) is normally cleaved by α-secretase, but can also be cleaved by β-secretase (BACE1) to produce C99 fragments in the endoplasmic reticulum (ER) membrane. C99 is subsequently cleaved to amyloid β (Aβ), the aggregation of which is known to cause Alzheimer's disease. Therefore, C99 remo...

journal_title：Biochemical and biophysical research communications

authors： Jang JK,Park KJ,Lee JH,Ko KY,Kang S,Kim IY

更新日期：2017-04-29 00:00:00

abstract：:Triple negative breast cancer (TNBC) is the hardest breast cancer subtype to treat due to lacking therapeutic target and treatment options. In this study, we found that SLUG expression was much higher in TNBC MDA-MB-231 cells than estrogen receptor alpha (ERα) positive breast cancer MCF7 cells. 4-hydroxytamoxifen (4-O...

journal_title：Biochemical and biophysical research communications

authors： Geng C,Li J,Ding F,Wu G,Yang Q,Sun Y,Zhang Z,Dong T,Tian X

更新日期：2016-04-22 00:00:00

abstract：:The stage V sporulation protein G (SpoVG) homolog of Staphylococcus aureus is a modulator of virulence factor synthesis and antibiotic resistance in this clinically important gram-positive pathogen. Here we demonstrate that SpoVG can be phosphorylated by the staphylococcal Ser/Thr protein kinase Stk1 and that phosphor...

journal_title：Biochemical and biophysical research communications

authors： Bischoff M,Brelle S,Minatelli S,Molle V

更新日期：2016-05-13 00:00:00

abstract：:In human platelets, the amounts of triphosphoinositides (TPI) and diphosphoinositides (DPI) increase after 30 sec and level off after 120 sec of thrombin stimulation. After 180 sec of thrombin challenge, TPI and DPI increase accounts for 66 and 80%, respectively. Polyphosphoinositide changes roughly parallel the relea...

journal_title：Biochemical and biophysical research communications

authors： Perret BP,Plantavid M,Chap H,Douste-Blazy L

更新日期：1983-01-27 00:00:00

abstract：:The effects of n-3 polyunsaturated fatty acids (n-3PUFA) on obesity and diabetes were examined using KK-Ay mice fed with perilla oil (P), soybean oil (S), or lard (L), and those containing 30% fish oil (PF, SF, or LF), containing eicosapentaenoic acid (EPA = 9.9%) and docosahexaenoic acid (DHA = 18.0%). Perilla oil co...

journal_title：Biochemical and biophysical research communications

authors： Hun CS,Hasegawa K,Kawabata T,Kato M,Shimokawa T,Kagawa Y

更新日期：1999-05-27 00:00:00

abstract：:The recognition and removal of interstrand cross-links is perhaps the least understood of all repair pathways in eukaryotic cells. We have shown previously that uncoupling of cross-links occurs in mammalian cell extracts and have identified a number of factors that mediate this process. However, we have not observed c...

journal_title：Biochemical and biophysical research communications

authors： Lu X,Zhang N,Vasquez K,Barton M,Legerski R

更新日期：2005-10-14 00:00:00

abstract：:The isolation and sequence analysis of the gene encoding the bovine atrial natriuretic peptide (ANP) precursor is described. The bovine-ANP coding sequences are located on three exons which are interrupted by two intervening sequences. Comparison of the bovine, human, rat and mouse ANP gene sequences reveals a common ...

journal_title：Biochemical and biophysical research communications

authors： Vlasuk GP,Miller J,Bencen GH,Lewicki JA

更新日期：1986-04-14 00:00:00

abstract：:We examined the expression of P-glycoprotein in human placentas and hydatidiform moles. Trophoblasts in all the examined placentas and moles expressed P-glycoprotein, and the size of the P-glycoprotein was smaller than that in multidrug-resistant human epidermoid carcinoma KB cells. The P-glycoprotein in the placenta ...

journal_title：Biochemical and biophysical research communications

authors： Nakamura Y,Ikeda S,Furukawa T,Sumizawa T,Tani A,Akiyama S,Nagata Y

更新日期：1997-06-27 00:00:00

abstract：:Despite the mitochondria ubiquitous nature many of their components display divergences in their expression profile across different tissues. Using the bioinformatics-approach of guilt by association (GBA) we exploited these variations to predict the function of two so far poorly annotated genes: Coiled-coil-helix-coi...

journal_title：Biochemical and biophysical research communications

authors： Martherus RS,Sluiter W,Timmer ED,VanHerle SJ,Smeets HJ,Ayoubi TA

更新日期：2010-11-12 00:00:00

abstract：:Reactive oxygen species (ROS) generated during inflammation and aging contribute to the resorption of articular cartilage. Low antioxidant levels are a risk factor for arthritis because they protect cartilage from ROS. N-Acetylcysteine (NAC) is a ROS scavenger and, depending upon the concentration, an anti-inflammator...

journal_title：Biochemical and biophysical research communications

authors： Li WQ,Dehnade F,Zafarullah M

更新日期：2000-09-07 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Biochemical and biophysical research communications

authors： Jiang J,Liu Y,Tang Y,Li L,Zeng R,Zeng S,Zhong M

更新日期：2016-12-03 00:00:00

abstract：:gamma S-Crystallin from shark eye lenses, formerly termed beta s crystallin in mammalian lenses, is structurally characterized in this study by cDNA cloning and sequencing. To facilitate sequence characterization of gamma S-crystallin possessing intermediate structural properties between beta- and gamma-crystallins, c...

journal_title：Biochemical and biophysical research communications

authors： Pan FM,Chuang MH,Chiou SH

更新日期：1997-11-07 00:00:00

abstract：:Activity of thalamic neurons has been shown to be modulated via type-1 metabotropic glutamate receptor (mGluR1) activation, which initiates an intracellular Ca signaling cascade involving phospholipase Cbeta4 (PLCbeta4) and leading to the activation of conventional protein kinase C (cPKC). In the present study, we inv...

journal_title：Biochemical and biophysical research communications

authors： Kameyama M,Yamaguchi I,Ichikawa K,Sugiyama T,Hirono M,Hori H,Ikeda M,Kuwahata Y,Eguchi N,Urade Y,Yoshioka T

更新日期：2003-04-25 00:00:00

abstract：:alpha 2,6 sialyltransferase towards the N-acetyllactosaminyl sequence (alpha 2,6 ST, E.C. 2.4.99.1) is one of the major sialyltransferases in human colonic cells; it strongly increases in human colorectal tumors and is largely expressed in fetal and neonatal rat colon. In this study we demonstrate that human colon car...

journal_title：Biochemical and biophysical research communications

authors： Dall'Olio F,Malagolini N,Serafini-Cessi F

更新日期：1992-05-15 00:00:00

abstract：:Myotonic dystrophy (DM) is an autosomal dominant human disorder, caused by the abnormal expansion of a CTG trinucleotide repeat in the 3' untranslated region of a protein kinase gene (DMPK). Muscle symptoms are a common feature of the disorder and in the adult onset cases there are increased patterns of muscle fibre d...

journal_title：Biochemical and biophysical research communications

authors： Okoli G,Carey N,Johnson KJ,Watt DJ

更新日期：1998-05-29 00:00:00

abstract：:Two fractions with high potency for reversing the inhibitory effect of Met-enkephalin on the electrically induced contractility of guinea-pig ileum have been purified from bovine brain extract. Unexpectedly, one isolated peptide was identified as [Val5]-angiotensin I and the other fraction was [Val5]-angiotensin II, a...

journal_title：Biochemical and biophysical research communications

authors： Kaneko S,Tamura S,Takagi H

更新日期：1985-01-16 00:00:00

abstract：:Nerve growth factor (NGF) elicits Akt translocation into the nucleus, where it phosphorylates nuclear targets. Here, we describe that Akt phosphorylation can promote the nuclear translocation of Akt and is necessary for its nuclear retention. Overexpression of Akt-K179A, T308A, S473A-mutant failed to show either nucle...

journal_title：Biochemical and biophysical research communications

authors： Xuan Nguyen TL,Choi JW,Lee SB,Ye K,Woo SD,Lee KH,Ahn JY

更新日期：2006-10-20 00:00:00

abstract：:We have identified by protein sequencing the precursor of beta protein in newborn rat brain. A rabbit antibody was raised against a synthetic peptide corresponding to the carboxyl-terminal 30 residues (666-695) of the putative beta-amyloid protein precursor (Kang et al. 1987). The antiserum recognized multiple bands a...

journal_title：Biochemical and biophysical research communications

authors： Takio K,Hasegawa M,Titani K,Ihara Y

更新日期：1989-05-15 00:00:00

abstract：:We have shown that the orphan receptor Germ Cell Nuclear Factor (GCNF) binds to a direct repeat of the sequence AGGTCA with zero base pair spacing (DR0). Here, we further characterize the binding characteristics of GCNF. We demonstrate that GCNF binds specifically to DR0s as a homodimer, and does not bind with high af...

journal_title：Biochemical and biophysical research communications

authors： Cooney AJ,Hummelke GC,Herman T,Chen F,Jackson KJ

更新日期：1998-04-07 00:00:00

abstract：:Infection and/or drug-mediated acute liver injury, the leading cause of lethal liver failure, is a critical health problem worldwide and lacks effective treatment. Here, we used Lipopolysaccharides (LPS)/D-galactosamine (D-gal)-treated primary hepatocytes to screen a natural library that contains 1130 chemicals. Baica...

journal_title：Biochemical and biophysical research communications

authors： Xiao T,Cui Y,Ji H,Yan L,Pei D,Qu S

更新日期：2021-01-01 00:00:00

abstract：:A 13 kb rat Cu/ZnSOD genomic clone has been purified from a rat liver genomic library and completely characterized by restriction mapping, detailed sequencing and Southern blot analysis. This gene spans approximately 6 kb and contains five exons and four introns. Comparison of rat, mouse, and human Cu/ZnSOD genes reve...

journal_title：Biochemical and biophysical research communications

authors： Hsu JL,Visner GA,Burr IA,Nick HS

更新日期：1992-07-31 00:00:00

abstract：:A single intraperitoneal injection of 275 mg of dimethyl sulphoxide (DMSO) to rats (100-125 g body weight) effectively uncouples oxidative phosphorylation in liver mitochondria during the period from 2 hr to 5 day post-injection. Higher doses of DMSO are inhibitory to mitochondrial respiration. DMSO has however no unc...

journal_title：Biochemical and biophysical research communications

authors： Mhatre SS,Chetty KG,Pradhan DS

更新日期：1983-01-14 00:00:00

abstract：:We have constructed a highly useful phage-displayed human antibody repertoire with limited cloning efforts. Our strategy was to maximize diversity during the first steps of library construction through the use of various lymphoid sources from several donors, inclusion of different immunoglobulin isotypes, and performa...

journal_title：Biochemical and biophysical research communications

authors： Rojas G,Lamdan H,Padron S,Munoz Y,Ayala M,Gavilondo JV

更新日期：2005-11-04 00:00:00

abstract：:A fully effective antimalarial vaccine must contain multiple proteins from the different development stages of Plasmodium falciparum parasites involved in host-cell invasion or their biologically active fragments. It must therefore include sporozoite molecules able to induce protective immunity by blocking the parasit...

journal_title：Biochemical and biophysical research communications

authors： Cifuentes G,Vanegas M,Martinez NL,Pirajan C,Patarroyo ME

更新日期：2009-07-10 00:00:00

abstract：:Glutathione (GSH) is the most abundant non-protein thiol that buffers reactive oxygen species in the brain. GSH does not reduce nitroxides directly, but in the presence of ascorbates, addition of GSH increases ascorbate-induced reduction of nitroxides. In this study, we used electron paramagnetic resonance (EPR) imagi...

journal_title：Biochemical and biophysical research communications

authors： Emoto MC,Matsuoka Y,Yamada KI,Sato-Akaba H,Fujii HG

更新日期：2017-04-15 00:00:00

abstract：:CD40-stimulated human B lymphocytes are highly permissive to a productive infection by the human immunodeficiency virus type 1. In these cells, nuclear factors involved in activation of the HIV-1 LTR, which contains the transcriptional control elements of the virus, are unknown. Transient expression assays with plasmi...

journal_title：Biochemical and biophysical research communications

authors： Lapointe R,Lemieux R,Darveau A

更新日期：1996-12-24 00:00:00

abstract：:Catalytic activities of cytochrome P450 2B4 lacking NH2-terminal amino acids 2-27 (wt Delta2B4) and that of truncated 2B4 containing a Pro to Ser mutation at position 221 were examined in a system supported by cumene hydroperoxide. Demethylation activities of either truncated 2B4 with N-methylaniline, N,N-dimethylanil...

journal_title：Biochemical and biophysical research communications

authors： Zhang Y,Pernecky SJ

更新日期：1999-04-29 00:00:00

abstract：:An Aspergillus niger (ficuum) genomic DNA lambda EMBL3 library was probed with a 354-bp DNA fragment obtained by polymerase chain reaction of A. niger DNA with oligonucleotides based on partial amino acid sequence of a pH 2.5 optimum acid phosphatase. A clone containing a 1605 bp segment (phyB) encoding the 479 amino ...

journal_title：Biochemical and biophysical research communications

authors： Ehrlich KC,Montalbano BG,Mullaney EJ,Dischinger HC Jr,Ullah AH

更新日期：1993-08-31 00:00:00

abstract：:PES1 (also known as Pescadillo), a nucleolar protein, was involved in biogenesis of ribosomal RNA. Up-regulation of PES1 has been documented in some human cancers, indicating that PES1 may play some crucial roles in tumorigenesis. In our previous study, it was found that silencing of PES1 resulted in decreased prolife...

journal_title：Biochemical and biophysical research communications

authors： Xie W,Qu L,Meng L,Liu C,Wu J,Shou C

更新日期：2013-02-15 00:00:00