Rat copper/zinc superoxide dismutase gene: isolation, characterization, and species comparison.

abstract：:It is known that the first step in the de novo synthesis of tetrahydrobiopterin from GTP is the conversion of GTP to dihydroneopterin triphosphate. Recent evidence supports the conclusion that beyond this first step, the pterin intermediates in the pathway are all at the tetrahydro level of reduction. We have now show...

journal_title：Biochemical and biophysical research communications

authors： Milstien S,Kaufman S

更新日期：1985-05-16 00:00:00

abstract：:The mitochondrial uncoupling protein UCP-1 uncouples respiration from ATP synthesis in brown adipose tissue (BAT) and thus energy is dissipated as heat. Recently two further isoforms have been identified which may play a similar role in other tissues. We have determined the effects of the rodent-selective beta3-adreno...

journal_title：Biochemical and biophysical research communications

authors： Emilsson V,Summers RJ,Hamilton S,Liu YL,Cawthorne MA

更新日期：1998-11-18 00:00:00

abstract：:Deinococcus radiodurans exhibits an extraordinary ability to withstand the lethal and mutagenic effects of DNA damaging agents, particularly, ionizing radiation. Available evidence indicates that efficient repair of DNA damage and protection of the chromosomal structure are mainly responsible for the radioresistance. ...

journal_title：Biochemical and biophysical research communications

authors： Hua Y,Narumi I,Gao G,Tian B,Satoh K,Kitayama S,Shen B

更新日期：2003-06-27 00:00:00

abstract：:ERRalpha (estrogen receptor-related receptor alpha) is a member of the nuclear receptor superfamily. To further our understanding of the detailed molecular mechanism of transcriptional regulation by ERRalpha, we searched for ERRalpha-interacting proteins using a yeast two-hybrid system by screening a human mammary gla...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Chen B,Chen J,Lou G,Chen S,Zhou D

更新日期：2008-05-16 00:00:00

abstract：:The wound healing process is initiated as soon as tissue is injured. Herein, we demonstrate that c-fos and c-myc mRNA transcripts are promptly increased in the wounded tissue in vivo and in vitro. A buffer solution from scraped serum-starved quiescent fibroblasts, when added to resting fibroblasts, caused the increase...

journal_title：Biochemical and biophysical research communications

authors： Tsuboi K,Yamaoka S,Maki M,Ohshio G,Tobe T,Hatanaka M

更新日期：1990-05-16 00:00:00

abstract：:During our human heart cDNA sequencing project, we have obtained a novel cDNA clone which is very similar in DNA and amino acid sequences to a rat/mouse cysteine-rich intestinal protein (1). Sequence analysis has shown that this human cysteine-rich heart protein (hCRHP) is a protein of 77 amino acids and possesses a L...

journal_title：Biochemical and biophysical research communications

authors： Tsui SK,Yam NY,Lee CY,Waye MM

更新日期：1994-11-30 00:00:00

abstract：:In Saccharomyces cerevisiae, the bud site selection of diploid cells is regulated by at least four persistent landmarks, Bud8p, Bud9p, Rax1p, and Rax2p. Bud8p and Bud9p are essential for the establishment of bipolar budding and localize mainly to the distal and the proximal poles, respectively. Their subcellular local...

journal_title：Biochemical and biophysical research communications

authors： Kato Y,Kawasaki H,Arakawa N,Hirano H

更新日期：2010-09-03 00:00:00

abstract：:S-nitrosothiols (SNOs) are endogenous signaling molecules with a broad spectrum of beneficial airway effects. SNOs are normally present in the airway, but levels tend to be low in cystic fibrosis (CF) patients. We and others have demonstrated that S-nitrosoglutathione (GSNO) increases the expression, maturation, and f...

journal_title：Biochemical and biophysical research communications

authors： Zaman K,Bennett D,Fraser-Butler M,Greenberg Z,Getsy P,Sattar A,Smith L,Corey D,Sun F,Hunt J,Lewis SJ,Gaston B

更新日期：2014-01-24 00:00:00

abstract：:Two repeated C2-like domains interacting with Ca2+ and phospholipid are found in synaptotagmin and Rabphilin-3A which are implicated in neurotransmitter release. Here we have isolated a cDNA encoding a novel protein having two repeated C2-like domains from a human brain cDNA library. The isolated cDNA encodes a protei...

journal_title：Biochemical and biophysical research communications

authors： Orita S,Sasaki T,Naito A,Komuro R,Ohtsuka T,Maeda M,Suzuki H,Igarashi H,Takai Y

更新日期：1995-01-17 00:00:00

abstract：:The effect of endothelin-1 (ET-1) on secretion and synthesis of rat atrial natriuretic peptide (rANP) as well as its mRNA levels was studied in primary cultures of neonatal rat atrial cardiocytes. ET-1 dose-dependently (10(-10)-10(-7) M) increased media and cellular rANP-like immunoreactivity as well as its cytoplasmi...

journal_title：Biochemical and biophysical research communications

authors： Fukuda Y,Hirata Y,Taketani S,Kojima T,Oikawa S,Nakazato H,Kobayashi Y

更新日期：1989-11-15 00:00:00

abstract：:Pancreatectomy (Px) is known to cause islet hypertrophy and is a putative method to mimic hyperglycemia representing type II diabetes mellitus. Therefore, finding new genes related to pancreatectomy will help to understand the molecular mechanism of hypertrophy and hyperglycemia, and may provide new diagnostic markers...

journal_title：Biochemical and biophysical research communications

authors： Lim HW,Lee JE,Shin SJ,Lee YE,Oh SH,Park JY,Seong JK,Park JS

更新日期：2002-12-20 00:00:00

abstract：:Metabolic syndrome describes a group of clinical features that together increase the incidence of coronary artery disease, stroke and type 2 diabetes. Insulin resistance is a major risk factor for developing metabolic syndrome. A chronic state of inflammation accompanies the accumulation of surplus lipids in adipose a...

journal_title：Biochemical and biophysical research communications

authors： Ko SH,Lee JK,Lee HJ,Ye SK,Kim HS,Chung MH

更新日期：2014-01-10 00:00:00

abstract：:G-rich is a Drosophila melanogaster selenoprotein, which is a homologue of human and mouse SelK. Subcellular localization analysis using GFP-tagged G-rich showed that G-rich was localized in the Golgi apparatus. The fusion protein was co-localized with the Golgi marker proteins but not with an endoplasmic reticulum (E...

journal_title：Biochemical and biophysical research communications

authors： Chen CL,Shim MS,Chung J,Yoo HS,Ha JM,Kim JY,Choi J,Zang SL,Hou X,Carlson BA,Hatfield DL,Lee BJ

更新日期：2006-10-06 00:00:00

abstract：:The effect of the length of ANF peptides on the inhibition of the norepinephrine-induced contraction was studied. Starting from the 26 residues ANF (Arg101-Tyr126), shorter N- and/or C-terminal fragments were produced, either by N-terminal chemical cleavage or C-terminal enzymatic digestion of ANF or both respectively...

journal_title：Biochemical and biophysical research communications

authors： Garcia R,Thibault G,Seidah NG,Lazure C,Cantin M,Genest J,Chrétien M

更新日期：1985-01-16 00:00:00

abstract：:Recent studies have established that polypeptide growth factors cause an elevation of the cytoplasmic pH (pHi) in cultured mammalian cells by stimulating Na+/H+ exchange. We show that vanadate, previously found to act as a mitogen for a number of cells, reversibly activates Na+/H+ exchange at micromolar concentrations...

journal_title：Biochemical and biophysical research communications

authors： Cassel D,Zhuang YX,Glaser L

更新日期：1984-01-30 00:00:00

abstract：:Cellular Ca(2+) homeostasis is maintained through the integrated and coordinated function of Ca(2+) transport molecules, Ca(2+) buffers and sensors. These molecules are associated with the plasma membrane and different cellular compartments, such as the cytoplasm, nucleus, mitochondria, and cellular reticular network,...

journal_title：Biochemical and biophysical research communications

authors： Krebs J,Agellon LB,Michalak M

更新日期：2015-04-24 00:00:00

abstract：:Model-free approaches (error-prone PCR to introduce random mutations, DNA shuffling to combine positive mutations, and screening of the resultant mutant libraries) have been used to enhance the catalytic activity and thermostability of alpha-aspartyl dipeptidase from Salmonella typhimurium, which is uniquely able to h...

journal_title：Biochemical and biophysical research communications

authors： Kong X,Liu Y,Gou X,Zhu S,Zhang H,Wang X,Zhang J

更新日期：2001-11-23 00:00:00

abstract：:Etoposide-induced 2.4 kb transcript (EI24, also known as PIG8) is a p53 target gene involved in cell growth suppression and apoptosis and known to be frequently altered in human cancers. Although EI24 expression is decreased in various cancers and is associated with colorectal cancer progression and metastasis, the ph...

journal_title：Biochemical and biophysical research communications

authors： Nam TW,Park SY,Lee JH,Roh JI,Lee HW

更新日期：2019-07-05 00:00:00

abstract：:A murine IgG mAb, WR321, selected for the ability to bind to phosphatidylinositol-4-phosphate and phosphatidylinositol-4,5-bisphosphate, but an inability to bind to any of 17 other lipids, including phosphatidylinositol, was examined as a probe for studying interactions of HIV-1 with primary human peripheral blood mon...

journal_title：Biochemical and biophysical research communications

authors： Matyas GR,Wieczorek L,Bansal D,Chenine AL,Sanders-Buell E,Tovanabutra S,Kim JH,Polonis V,Alving CR

更新日期：2010-11-26 00:00:00

abstract：:Progesterone (Pg) is an essential steroid hormone during mammary gland development and tumorigenesis, including the maintenance of epithelial stem/progenitor cells. Pg functions through interaction with the progesterone receptors (PR) and Pg-PR signaling is thought to be mediated by key transcription factors, which ar...

journal_title：Biochemical and biophysical research communications

authors： Li M,Zhao D,Ma G,Zhang B,Fu X,Zhu Z,Fu L,Sun X,Dong JT

更新日期：2013-01-04 00:00:00

abstract：:Studies examining the relationship between cellular sortilin and VLDL-B100 secretion demonstrate inconsistent results. Current studies explore the possibility that discrepancies may be related to insulin sensitivity. McArdle RH7777 cells (McA cells) cultured under serum enriched conditions lose sensitivity to insulin....

journal_title：Biochemical and biophysical research communications

authors： Sparks RP,Guida WC,Sowden MP,Jenkins JL,Starr ML,Fratti RA,Sparks CE,Sparks JD

更新日期：2016-09-16 00:00:00

abstract：:AmB is an antifungal drug of polyene. Although it is prone to nephrotoxicity, it is still the gold standard in the clinical treatment of fungal infection. Sterol plays a decisive role in the drug activity of AmB. The antifungal activity of AmB depends on ergosterol in fungal membranes, and its toxicity is related to c...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Ma Y,Hou S

更新日期：2020-01-15 00:00:00

abstract：:Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders and is characterized by impaired attention, hyperactivity, and impulsivity. While multiple etiologies are implicated in ADHD, its underlying mechanism(s) remain unclear. Although previous studies have suggested dysre...

journal_title：Biochemical and biophysical research communications

authors： Nguyen Nguyen HT,Kato H,Sato H,Yamaza H,Sakai Y,Ohga S,Nonaka K,Masuda K

更新日期：2019-06-11 00:00:00

abstract：:MutT-related proteins degrade 8-oxo-7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP), a mutagenic substrate for DNA synthesis, in the nucleotide pool, thereby preventing DNA replication errors. During a search of GenBank EST database, we found a new member of MutT-related protein, MTH2, which possesses the 23-amino...

journal_title：Biochemical and biophysical research communications

authors： Cai JP,Ishibashi T,Takagi Y,Hayakawa H,Sekiguchi M

更新日期：2003-06-13 00:00:00

abstract：:Allelic variants of the genes for chemokine receptors and their natural ligands, the chemokines, and cytokines can affect HIV-1 disease progression. This study investigates the level of expression of the CCR5-Delta32, CCR2b-641, RANTES In1.1C, SDF-1 3'A, IL-10-5'-592A and IL-4-589T alleles in two unique HIV-1 infected...

journal_title：Biochemical and biophysical research communications

authors： Mahajan SD,Agosto-Mojica A,Aalinkeel R,Reynolds JL,Nair BB,Sykes DE,Martinez J,Adams J,Singh N,Bernstein Z,Hsiao CB,Schwartz SA

更新日期：2010-05-28 00:00:00

abstract：:Recent environmental sampling around a landfill site in the UK demonstrated that unidentified xenoestrogens were present at higher levels than control sites; that these xenoestrogens were capable of super-activating (resisting ligand-dependent antagonism) the murine variant 2 ERβ and that the ionic liquid 1-octyl-3-me...

journal_title：Biochemical and biophysical research communications

authors： Leitch AC,Lakey AF,Hotham WE,Agius L,Kass GEN,Blain PG,Wright MC

更新日期：2018-09-10 00:00:00

abstract：:Previous genetic evidence led to the conclusion that proteinase B of yeast was not involved in the function of chitin synthetase 1 (Chs1), based on the demonstration of normal septum formation, cell division and chitin deposition in mutants devoid of the proteinase (Zubenko, G.S., Mitchell, A.P., and Jones, E.W. (1979...

journal_title：Biochemical and biophysical research communications

authors： Silverman SJ,Shaw JA,Cabib E

更新日期：1991-01-15 00:00:00

abstract：:GLUT4, the insulin-responsive glucose transporter expressed primarily in muscle and adipose tissue, contains a single N-glycosylation site. We characterized a mutant GLUT4 lacking the N-glycosylation site (Asn57-->Gln) in primary cultures of rat adipose cells. We transiently transfected cells with expression vectors f...

journal_title：Biochemical and biophysical research communications

authors： Ing BL,Chen H,Robinson KA,Buse MG,Quon MJ

更新日期：1996-01-05 00:00:00

abstract：:Oligodendrocytes (OLGs) are cells from the central nervous system that synthesize, assemble, and maintain myelin, the multilamellar membrane that surrounds axons and facilitates the fast conduction of nerve impulses. We have shown that OLGs initiate their myelinogenic phenotype upon adhesion to GRASP, a heparin-bindin...

journal_title：Biochemical and biophysical research communications

authors： Szuchet S,Plachetzki DC,Eaton KS

更新日期：2001-05-18 00:00:00

abstract：:Bone marrow stromal cell antigen 2 (BST-2) is a type II transmembrane protein that is known to be a therapeutic target in several types of cancer. However, despite its clinical importance, the roles of BST-2 expression have remained elusive. Here, we found that BST-2 expression is up-regulated in tamoxifen-resistant M...

journal_title：Biochemical and biophysical research communications

authors： Yi EH,Yoo H,Noh KH,Han S,Lee H,Lee JK,Won C,Kim BH,Kim MH,Cho CH,Ye SK

更新日期：2013-06-14 00:00:00