Function of P-glycoprotein expressed in placenta and mole.

abstract：:Protein acetylation modification has been implicated in many cellular processes but the direct evidence for the involvement of protein acetylation in signal transduction is very limited. In the present study, we found that an alkylating agent methyl methanesulfonate (MMS) induces a robust and reversible hyperacetylati...

journal_title：Biochemical and biophysical research communications

authors： Lee MY,Kim MA,Kim HJ,Bae YS,Park JI,Kwak JY,Chung JH,Yun J

更新日期：2007-08-24 00:00:00

abstract：:In the present paper we report evidence about the formation of polyprenyl-phosphate monosaccharides, their elongation products and the assembly of dolichyl-diphosphate-oligosaccharide to endogenous T47D clone 11 proteins upon incubation with [14C]glucose. The influence of estradiol and two nonesteroidal antiestrogens ...

journal_title：Biochemical and biophysical research communications

authors： Santa Cruz AR,Medrano EE,Baldi A

更新日期：1985-01-16 00:00:00

abstract：:Our previous study demonstrated that angiotensin II (Ang II) upregulates the expression of Kv1.5, a promising target for atrial fibrillation (AF) therapy, by activating ROS-dependent P-Smad2/3 and P-ERK 1/2. A recent study showed that hydrogen sulfide (H2S) may modulate the effects of angiotensin II (Ang II) by inhibi...

journal_title：Biochemical and biophysical research communications

authors： Lu G,Xu C,Tang K,Zhang J,Li Q,Peng L,Wang Y,Huang Z,Gao X

更新日期：2017-01-29 00:00:00

abstract：:Excessive cellular cholesterol is transported to the liver by a pathway called 'reverse cholesterol transport.' Scavenger receptor class B, type I (SR-BI) mediates cholesterol uptake in the liver. Polyunsaturated fatty acids, known to activate peroxisome proliferator-activated receptor (PPAR), have been reported to in...

journal_title：Biochemical and biophysical research communications

authors： Malerød L,Sporstøl M,Juvet LK,Mousavi A,Gjøen T,Berg T

更新日期：2003-06-06 00:00:00

abstract：:Lafora disease, a progressive myoclonus epilepsy, is an autosomal recessive disease caused in approximately 80% of cases by mutation of the EPM2A gene, which encodes a dual specificity protein phosphatase called laforin. In addition to its phosphatase domain, laforin contains an N-terminal carbohydrate-binding domain ...

journal_title：Biochemical and biophysical research communications

authors： Wang W,Roach PJ

更新日期：2004-12-17 00:00:00

abstract：:Serine416 of human tau protein is believed to be phosphorylated in Alzheimer neurofibrillary tangles. We synthesized a fragment of tau, consisting of amino acids 408-421 in both non-phosphorylated and serine416-phosphorylated forms. Circular dichroism in a trifluoroethanol-water mixture indicated a beta-turn----beta-p...

journal_title：Biochemical and biophysical research communications

authors： Lang E,Szendrei GI,Elekes I,Lee VM,Otvos L Jr

更新日期：1992-01-15 00:00:00

abstract：:The purpose of this study was to examine whether mechanical tensile forces affect estrogen regulation of collagen synthesis of anterior cruciate ligament fibroblasts at the mRNA level. Estrogen was studied at three physiologic levels, 10(-11), 10(-10), and 10(-9)M. The results revealed that estrogen alone stimulated T...

journal_title：Biochemical and biophysical research communications

authors： Lee CY,Smith CL,Zhang X,Hsu HC,Wang DY,Luo ZP

更新日期：2004-05-14 00:00:00

abstract：:GroEL-like particles of Thermus aquaticus are homo-oligomeric complexes of two stacked seven member rings, sedimenting in the gradient at 20S. The apparent molecular mass of the native particles is 820,000 (+/- 30,000). The protein complex is composed with one polypeptide of M(r) 59,000. Immunoblotting results and N-t...

journal_title：Biochemical and biophysical research communications

authors： Mikulík K,Benada O

更新日期：1993-12-15 00:00:00

abstract：:Signal transduction by transforming growth factor-beta (TGF-beta) involves the formation of a heteromeric complex of two transmembrane serine/threonine kinase receptors, type I (T beta R-I) and type II (T beta R-II). In the region preceeding the kinase domain of T beta R-I there is a glycine- and serine-rich sequence,...

journal_title：Biochemical and biophysical research communications

authors： Franzén P,Heldin CH,Miyazono K

更新日期：1995-02-15 00:00:00

abstract：:The ubiquitin-proteasome pathway is an important regulatory system for the lifetime of inducible nitric-oxide synthase (iNOS), a high-output isoform compared to neuronal NOS (nNOS) and endothelial NOS (eNOS), to prevent overproduction of NO that could trigger detrimental effects such as cytotoxicity. Two E3 ubiquitin ...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto K,Nishiya T,Maekawa S,Horinouchi T,Ogasawara K,Uehara T,Miwa S

更新日期：2011-05-27 00:00:00

abstract：:The glucose-dependent insulinotropic peptide receptor (GIP-R) is a member of the secretin and parathyroid hormone (PTH) family of seven transmembrane-spanning receptors. Point mutations of a histidine at the junction between the first intracellular loop and the second membrane-spanning domain and a threonine in the si...

journal_title：Biochemical and biophysical research communications

authors： Tseng CC,Lin L

更新日期：1997-03-06 00:00:00

abstract：:In this work, we examined the functions of the female hormone "estrogen" on spermatogenesis of the Japanese eel (Anguilla japonica). Estradiol-17beta (E(2)), a natural estrogen in vertebrates, was present in the serum and its receptor was expressed in the testis during the whole process of spermatogenesis. Spermatogon...

journal_title：Biochemical and biophysical research communications

authors： Miura T,Miura C,Ohta T,Nader MR,Todo T,Yamauchi K

更新日期：1999-10-14 00:00:00

abstract：:Lysinuric protein intolerance (LPI; MIM 222700) is an autosomal recessive disorder characterized by defective transport of cationic amino acids lysine, arginine and ornithine. The defect is localized in the basolateral membrane of polar epithelial cells of the renal tubules and intestine. The SLC7A7 (solute carrier fa...

journal_title：Biochemical and biophysical research communications

authors： Toivonen M,Mykkänen J,Aula P,Simell O,Savontaus ML,Huoponen K

更新日期：2002-03-15 00:00:00

abstract：:UCP-2 is a member of the emerging family of UCP homologues. Upon high-fat feeding, UCP-2 mRNA levels are increased in epididymal fat pads of A/J mice, suggesting that the flux of fatty acids entering adipose tissue may regulate UCP-2 gene expression. Since fatty acids act as positive transcriptional regulators of lipi...

journal_title：Biochemical and biophysical research communications

authors： Aubert J,Champigny O,Saint-Marc P,Negrel R,Collins S,Ricquier D,Ailhaud G

更新日期：1997-09-18 00:00:00

abstract：:Toddalia asiatica (L.) Lam. (T. asiatica) has been utilized traditionally for medicinal purposes such as the treatment of diabetes. Currently, the extract is considered to be a good source of anti-diabetic agents, but the active compounds have yet to be identified. In this study, we investigated the effects of fractio...

journal_title：Biochemical and biophysical research communications

authors： Watanabe A,Kato T,Ito Y,Yoshida I,Harada T,Mishima T,Fujita K,Watai M,Nakagawa K,Miyazawa T

更新日期：2014-10-31 00:00:00

abstract：:Until today, 14 isoforms of mammalian calpains have been identified, including calpain-5. The C. elegans calpain-5 homologue tra-3 is reported to be essential for necrotic neuronal cell death. In this study, we cloned and characterized rat calpain-5, which is highly homologous to human and mouse sequences. The nucleot...

journal_title：Biochemical and biophysical research communications

authors： Waghray A,Wang DS,McKinsey D,Hayes RL,Wang KK

更新日期：2004-11-05 00:00:00

abstract：:Simultaneous patch-clamp and Ca2+ fluorescence measurements have revealed depolarising oscillations in the membrane potential of arterial (pulmonary) myocytes in response to adenosine 5'-triphosphate (ATP) and endothelin-1 (ET-1). These oscillations (i) are due to the preferential activation of Ca(2+)-activated Cl-, o...

journal_title：Biochemical and biophysical research communications

authors： Bakhramov A,Hartley SA,Salter KJ,Kozlowski RZ

更新日期：1996-10-03 00:00:00

abstract：:C-terminal binding protein 2 (CtBP2) is a transcriptional co-repressor involved in cell migration, apoptosis, and tumorization. Up-regulation of CtBP2 is implicated in various human cancers including breast cancers. In our present study, we found that the C-terminus of Hsc70-interacting protein (CHIP) regulated the st...

journal_title：Biochemical and biophysical research communications

authors： Lee JS,Yoo SJ

更新日期：2013-03-15 00:00:00

abstract：:As the development of sequencing technology, more and more circular RNAs (circRNAs) are identified in human cancer tissues. Increasing evidences imply circRNAs are important regulators in tumor progression. Nevertheless, how circRNAs participate in breast cancer development and progression is not well understood. In t...

journal_title：Biochemical and biophysical research communications

authors： Liu Y,Lu C,Zhou Y,Zhang Z,Sun L

更新日期：2018-07-20 00:00:00

abstract：:Bacillus thuringiensis (Bt), considered a safe insecticide, produces insecticidal proteins named Cry during sporulation, which possess exceptional immunological properties. In this work using an immunohistochemical test we demonstrated that Cry1Ac protoxin (pCry1Ac) binds to the mucosal surface of the mouse small inte...

journal_title：Biochemical and biophysical research communications

authors： Vázquez-Padrón RI,Gonzáles-Cabrera J,García-Tovar C,Neri-Bazan L,Lopéz-Revilla R,Hernández M,Moreno-Fierro L,de la Riva GA

更新日期：2000-04-29 00:00:00

abstract：:Lysenin, a hemolytic protein derived from the body fluid of earthworm, was incorporated into artificial bilayer membranes. Upon insertion, it formed a voltage-dependent large conductance channel in asolectin bilayers in a sphingomyelin-dependent manner. The channel had low ion-selectivity. Single-channel conductance w...

journal_title：Biochemical and biophysical research communications

authors： Ide T,Aoki T,Takeuchi Y,Yanagida T

更新日期：2006-07-21 00:00:00

abstract：:The partitioning of the acylenzyme acetyl-(Gly)n-Phe(NO2)-chymotrypsin (n = 0,1,2) to peptide and peptide acid is observed spectrophotometrically. Values of partitioning ratios for various nucleophiles are calculated from the spectral data. They are a measure for the "true" nucleophile reactivity and are useful in the...

journal_title：Biochemical and biophysical research communications

authors： Petkov DD,Stoineva I

更新日期：1984-01-13 00:00:00

abstract：:TREK1 is a member of the tandem-P domain K+ channel family which is expressed almost exclusively in the nervous system. It is modulated by a number of important factors including arachidonic acid and cell swelling. Since both factors are associated with brain ischemia, it has been suggested that activation of TREK1 ma...

journal_title：Biochemical and biophysical research communications

authors： Miller P,Kemp PJ,Peers C

更新日期：2005-06-17 00:00:00

abstract：BACKGROUND:PTK6 is involved in cell proliferation, invasion and migration. Patients with lower PTK6 expression predicts poor prognosis of LSCC. However, the mechanism of PTK6 in LSCC progression remains unclear. We investigated the role of PTK6 in the pathogenesis of LSCC. METHODS:Human LSCC tissues and paired adjacen...

journal_title：Biochemical and biophysical research communications

authors： Wu D,Zhang X,Liu Z,Yan H,Mai J,Zhao Z,Zhong Q,Liu X

更新日期：2018-09-10 00:00:00

abstract：:Ubiquitylation is an essential posttranslational protein modification that is implicated in a diverse array of cellular functions. Although cells contain eight structurally distinct types of polyubiquitin chains, detailed function of several chain types including K29-linked chains has remained largely unclear. Current...

journal_title：Biochemical and biophysical research communications

authors： Tsuchiya H,Tanaka K,Saeki Y

更新日期：2013-06-28 00:00:00

abstract：:AMP-activated protein kinase (AMPK) plays a key role in maintaining intracellular and whole-body energy homeostasis. Activation of AMPK has been shown to ameliorate the symptoms of metabolic diseases, such as type 2 diabetes and obesity. Here we show that gambogic acid (GB), a known antitumor agent, activates AMPK by ...

journal_title：Biochemical and biophysical research communications

authors： Zhao B,Shen H,Zhang L,Shen Y

更新日期：2012-07-20 00:00:00

abstract：:Hexokinase 1 (HK1) purified from rat brain exhibits protein kinase activity, including autophosphorylation and phosphorylation of histone H2A. This protein kinase activity is observed only in the absence of the HK1 carbohydrate substrate, glucose. Analysis of the ATP-binding domains of the mammalian HK1 protein sequen...

journal_title：Biochemical and biophysical research communications

authors： Adams V,Griffin LD,Gelb BD,McCabe ER

更新日期：1991-06-28 00:00:00

abstract：:Incubation of rabbit aortic endothelial cells (RAEC) with oxidized low-density lipoprotein (LDL) for 16 h resulted in stimulation of calcium uptake and increased release of nitric oxide (NO) by these cells. Accompanying inhibition of protein tyrosine phosphatase (PTP) activity in these cells was also observed. Convers...

journal_title：Biochemical and biophysical research communications

authors： Fries DM,Penha RG,D'Amico EA,Abdalla DS,Monteiro HP

更新日期：1995-02-06 00:00:00

abstract：:FamD1 is a novel CloQ/NphB-family indole prenyltransferase which involves in hapalindole-type alkaloid biosynthesis. Here the native FamD1 structure and three protein-ligand complexes are analyzed to investigate the molecular basis of substrate binding and catalysis. FamD1 adopts a typical ABBA architecture of aromati...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Chen CC,Yang Y,Liu W,Ko TP,Shang N,Hu X,Xie Y,Huang JW,Zhang Y,Guo RT

更新日期：2018-01-08 00:00:00

abstract：:HSP60 has been proved to be closely related to atherosclerosis due to its antigenicity. To determine this antigenicity effect, the ApoE-/- mice were fed with western-type diet and HSP60 was administrated orally or subcutaneously (SC) for potential vaccine against atherosclerosis. Here, we observed the ApoE-/- mice wit...

journal_title：Biochemical and biophysical research communications

authors： Hu Y,Chen Z,Jiang L,Chen F,Jin R,Cheng L

更新日期：2018-04-15 00:00:00