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Calcitonin gene-related peptide(CGRP) stimulates the release of atrial natriuretic peptide(ANP) from isolated rat atria.

Abstract：

:The effect of calcitonin gene-related peptide(CGRP) on the release of atrial natriuretic peptide(ANP) was studied in spontaneously beating, isolated rat atria. CGRP stimulated the ANP release in a dose-dependent manner. When the atria were incubated with a combination of phentolamine, propranolol, and atropine, these antagonists blocked neither the rise in ANP release nor the positive chronotropic and inotropic effects of CGRP. Therefore, we conclude that CGRP stimulates ANP release as well as cardiac contractility independently of adrenergic and cholinergic receptors.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yamamoto A,Kimura S,Hasui K,Fujisawa Y,Tamaki T,Fukui K,Iwao H,Abe Y

doi

10.1016/s0006-291x(88)81304-4

subject

Has Abstract

pub_date

1988-09-30 00:00:00

pages

1452-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)81304-4

journal_volume

155

pub_type

杂志文章

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