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Rabbit FKBP59-heat shock protein binding immunophillin (HBI) is a calmodulin binding protein.

Abstract：

:FKBP59-HBI, a heat shock protein hsp90-binding immunophilin that was originally detected in heterooligomer forms of steroid receptors, is retained on Calmodulin (CAM)-Sepharose 4B in the presence of 2 mM Ca2+ and is eluted by EGTA, demonstrating a specific p59-CAM interaction. The p59 amino acid sequence reveals the presence of two putative CAM binding sites in a helix regions of the protein, as well as PEST sequences which are generally present in CAM-binding proteins. In vitro proteolysis by calpain II (a Ca(2+)-activated neutral protease), another feature of CAM-binding proteins, generates shorter peptides revealed by the mAb EC1, but not by the pAb 173 which recognizes the C-terminal of the protein. The potential function of CAM binding by the hsp90-binding immunophilin is discussed.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Massol N,Lebeau MC,Renoir JM,Faber LE,Baulieu EE

doi

10.1016/0006-291x(92)90448-t

subject

Has Abstract

pub_date

1992-09-30 00:00:00

pages

1330-5

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(92)90448-T

journal_volume

187

pub_type

杂志文章

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