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Direct in vivo gene introduction into rat kidney.

Abstract：

:We established a simple and highly efficient method for in vivo gene transfer using HVJ (Sendai virus) and liposomes. Plasmid DNA and high mobility group 1 (HMG1) protein were co-encapsulated in liposomes by agitation and sonication and were co-introduced into cells by HVJ-mediated membrane fusion. pACT SVT DNA, as a reporter gene, was introduced into the kidney of intact rats through a cannula in the renal artery, and SV40 large T antigen was detected by enzyme immunohistochemistry in glomerular cells 4 days after its introduction. This newly developed kidney-directed gene transfer method should be useful not only in basic research but also in potential gene therapeutics of renal diseases.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Tomita N,Higaki J,Morishita R,Kato K,Mikami H,Kaneda Y,Ogihara T

doi

10.1016/s0006-291x(05)80784-3

subject

Has Abstract

pub_date

1992-07-15 00:00:00

pages

129-34

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)80784-3

journal_volume

186

pub_type

杂志文章

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