Superoxide-mediated release of iron from ferritin by some flavoenzymes.

abstract：:Traumatic spinal cord injury (SCI) is a major cause of death and lifelong disability in the world. However, the pathological process of SCI has not been fully understood. F-box/WD repeat-containing protein 5 (FBXW5), a subunit of the SCF-type E3 ubiquitin ligase complex, plays an essential role in regulating various p...

journal_title：Biochemical and biophysical research communications

authors： Zhao P,Chao W,Li W

更新日期：2019-06-25 00:00:00

abstract：:PDX-1 plays a central role in differentiation of insulin-producing cells. We previously reported that exogenous PDX-1 protein can permeate cells and induce insulin gene expression in progenitor cells. These data suggest a strategy for facilitating differentiation into insulin-producing cells. Here we show the mechanis...

journal_title：Biochemical and biophysical research communications

authors： Noguchi H,Matsushita M,Matsumoto S,Lu YF,Matsui H,Bonner-Weir S

更新日期：2005-06-24 00:00:00

abstract：:It is well established that lipid metabolism is controlled, in part, by circadian clocks. However, circadian clocks lose temporal precision with age and correlates with elevated incidence in dyslipidemia and metabolic syndrome in older adults. Because our lab has shown that lipoic acid (LA) improves lipid homeostasis ...

journal_title：Biochemical and biophysical research communications

authors： Keith D,Finlay L,Butler J,Gómez L,Smith E,Moreau R,Hagen T

更新日期：2014-07-18 00:00:00

abstract：:Members of the T cell Ig and mucin (TIM) family have recently been implicated in the control of T cell-mediated immune responses. In this study, we found TIM-1 expression on anti-IgM- or anti-CD40-stimulated splenic B cells, which was further up-regulated by the combination of anti-IgM and anti-CD40 Abs. On the other ...

journal_title：Biochemical and biophysical research communications

authors： Ma J,Usui Y,Takeda K,Harada N,Yagita H,Okumura K,Akiba H

更新日期：2011-03-11 00:00:00

abstract：:Exposure of pancreatic islet B-cells to D-glucose and many other insulinotropic agents results in an increase of cytoplasmic calcium concentration, which triggers the exocytosis of secretroy granules. Previous studies have demonstrated that calcium itself, at concentrations ranging from 2 to 18 mM, is able to induce a...

journal_title：Biochemical and biophysical research communications

authors： Rasschaert J,Malaisse WJ

更新日期：1999-11-02 00:00:00

abstract：:The 15-kDa selenoprotein (Sep15) has been implicated in etiology of some types of cancer. Herein, inducible RNAi cell lines were established and cell morphology and motility were analyzed. The majority of Sep15-deficient cells (>95%) formed membrane blebs in a dynamic manner. Blebbing cells transformed cell morphology...

journal_title：Biochemical and biophysical research communications

authors： Bang J,Jang M,Huh JH,Na JW,Shim M,Carlson BA,Tobe R,Tsuji PA,Gladyshev VN,Hatfield DL,Lee BJ

更新日期：2015-01-24 00:00:00

abstract：:This study investigated regulation of autophagy in slow-twitch soleus and fast-twitch plantaris muscles in fasting-related atrophy. Male Fischer-344 rats were subjected to fasting for 1, 2, or 3 days. Greater weight loss was observed in plantaris muscle than in soleus muscle in response to fasting. Western blot analys...

journal_title：Biochemical and biophysical research communications

authors： Ogata T,Oishi Y,Higuchi M,Muraoka I

更新日期：2010-03-26 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) catalyzes the rate-limiting step in the generation of prostanoids, and is thus one of the key players in the inflammatory process. Contrary to the constitutively expressed isoform COX-1, the expression of COX-2 is rapidly and transiently upregulated following pathological stimuli but little is...

journal_title：Biochemical and biophysical research communications

authors： Brender S,Barki-Harrington L

更新日期：2014-08-22 00:00:00

abstract：:Follicle-stimulating hormone (FSH) levels increase estrogen biosynthesis in obese menopausal women. Ovariectomized mice and 3T3-L1 cells were used to explore estrogen biosynthesis in the decline of ovarian function. After ovariectomy, lipid deposition, and FSH and estrogen levels changed, and feed intake increased sig...

journal_title：Biochemical and biophysical research communications

authors： Cui H,Zhao G,Wen J,Tong W

更新日期：2018-01-15 00:00:00

abstract：:Glycogen-storage disease type II (GSD II, acid maltase deficiency, Pompe's disease) is caused by defects in the lysosomal acid alpha-glucosidase (GAA) gene. Clinically, patients with the severe infantile form of GSD II have muscle weakness and cardiomyopathy eventually leading to death before the age of two years. Pat...

journal_title：Biochemical and biophysical research communications

authors： Nicolino M,Puech JP,Letourneur F,Fardeau M,Kahn A,Poenaru L

更新日期：1997-06-09 00:00:00

abstract：:Recent advances in cancer biology reveal the importance of metabolic changes in cancer; however, less is known about how metabolic pathways in tumors are regulated in vivo. Here, we report analysis of the lung cancer metabolism based on different surgical procedures, namely lobectomy and partial resection. In lobectom...

journal_title：Biochemical and biophysical research communications

authors： Kikuchi N,Soga T,Nomura M,Sato T,Sakamoto Y,Tanaka R,Abe J,Morita M,Shima H,Okada Y,Tanuma N

更新日期：2020-09-10 00:00:00

abstract：:Casper/c-FLIP is a caspase-8-related molecule critically involved in regulation of death receptor-induced apoptosis. It has been shown that Casper can either promote or antagonize apoptosis and can activate the transcription factor NF-kappaB. The exact functions of Casper are controversial. To further understand how C...

journal_title：Biochemical and biophysical research communications

authors： Li Z,Zhang J,Chen D,Shu HB

更新日期：2003-10-03 00:00:00

abstract：:We present the first direct biochemical evidence for the turnover of intact type VI collagen microfibrils. Matrix-degrading enzymes of the serine proteinase class, including rat mast cell chymases I and II, human mast cell tryptase, neutrophil elastase, cathepsin G and trypsin, were able to catabolize intact type VI c...

journal_title：Biochemical and biophysical research communications

authors： Kielty CM,Lees M,Shuttleworth CA,Woolley D

更新日期：1993-03-31 00:00:00

abstract：:Parathymosin has been purified from calf liver and its primary sequence established, except for a segment containing approximately 11 amino acid residues in the central part of the polypeptide chain. Bovine parathymosin contains approximately 101 amino acid residues and shows 90% identity with rat parathymosin, with s...

journal_title：Biochemical and biophysical research communications

authors： Panneerselvam C,Clinton M,Wellner D,Horecker BL

更新日期：1988-09-15 00:00:00

abstract：:In a previous genome-wide association study on milk production traits in Chinese Holstein population, we revealed VPS28 gene was highly expressed in mammary gland tissue and a -58C > T mutation in 5'-UTR of it was significantly associated with milk fat content traits. In this study, we explored the effect of this -58C...

journal_title：Biochemical and biophysical research communications

authors： Liu L,Zhang Q

更新日期：2019-03-19 00:00:00

abstract：:The IGF-1 receptor (IGF-1R) and MT1-MMP are synthesized as larger precursor proproteins, which require endoproteolytic activation by the proprotein convertases (PCs) furin/PC5 to gain full biological activity. The aim of this study was to investigate the contribution of PCs to IGF-1R and/or MT1-MMP activation in vascu...

journal_title：Biochemical and biophysical research communications

authors： Stawowy P,Kallisch H,Kilimnik A,Margeta C,Seidah NG,Chrétien M,Fleck E,Graf K

更新日期：2004-08-27 00:00:00

abstract：:A novel human GPCR gene was cloned by PCR with degenerate primers designed from cannabinoid type 1 receptor (CB1) sequences and a full-length clone was isolated by screening of a human genomic DNA library. This gene, termed EDG-3, is highly homologous (51.9 % overall and 69.2 % in seven transmembrane regions) to human...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi F,Tokuda M,Hatase O,Brenner S

更新日期：1996-10-14 00:00:00

abstract：:hPepT1 is a proton-coupled peptide transporter that mediates the absorption of di- and tripeptides. Here we show that tyrosine 167 (Y167) in transmembrane domain 5 (TMD5) of this 12-transmembrane spanning protein contributes to its transport function. We identified this particular amino acid by a computer model of the...

journal_title：Biochemical and biophysical research communications

authors： Yeung AK,Basu SK,Wu SK,Chu C,Okamoto CT,Hamm-Alvarez SF,von Grafenstein H,Shen WC,Kim KJ,Bolger MB,Haworth IS,Ann DK,Lee VH

更新日期：1998-09-08 00:00:00

abstract：:Inflammation has been implicated in a variety of psychiatric disorders. We aimed to determine whether levels of complement C5 protein in the cerebrospinal fluid (CSF), which may reflect activation of the complement system in the brain, are altered in patients with major psychiatric disorders. Additionally, we examined...

journal_title：Biochemical and biophysical research communications

authors： Ishii T,Hattori K,Miyakawa T,Watanabe K,Hidese S,Sasayama D,Ota M,Teraishi T,Hori H,Yoshida S,Nunomura A,Nakagome K,Kunugi H

更新日期：2018-03-04 00:00:00

abstract：:Hepatitis B, a major public health concern worldwide, is caused by hepatitis type B virus, a hepdnavirus that infects only human and certain nonhuman primates, and replicates strictly in hepatocytes. By using the techniques of slot and Southern blot DNA hybridization, and electron microscopy, the presence of HBV was i...

journal_title：Biochemical and biophysical research communications

authors： Pao CC,Wu SY,Hung IJ,Ng KT,Liaw YF,Lo SJ

更新日期：1987-07-31 00:00:00

abstract：:The selectivity filter and adjacent regions in the bacterial KcsA and inwardly rectifying K(+) (Kir) channels reveal significant conformational changes that cause the channel pore to transition from an activated to inactive state (C-type inactivation) once the channel is open. The meshwork of residues stabilizing the ...

journal_title：Biochemical and biophysical research communications

authors： Raja M

更新日期：2011-09-16 00:00:00

abstract：:The effect of extracellular ATP on intracellular free Ca2+ was characterized in quin2-loaded parotid acinar cells. ATP specifically increased the intracellular Ca2+ concentration six-fold above a basal level of 180 nM. Of other purine nucleotides tested, only adenylylthiodiphosphate (ATP gamma S) had significant activ...

journal_title：Biochemical and biophysical research communications

authors： McMillian MK,Soltoff SP,Cantley LC,Talamo BR

更新日期：1987-12-16 00:00:00

abstract：:Alveolar epithelial type I and type II cells (AEC I and II) are closely aligned in alveolar surface. There is much interest in the precise identification of AEC I and II in order to separate and evaluate functional and other properties of these two cells. This study aims to identify specific AEC I and AEC II cell mark...

journal_title：Biochemical and biophysical research communications

authors： Chen Z,Jin N,Narasaraju T,Chen J,McFarland LR,Scott M,Liu L

更新日期：2004-07-02 00:00:00

abstract：:The human leukemia cell line KU812 had been described as an immature prebasophilic cell line and exhibits a potential to differentiate into mature basophils. We studied the effect of interleukin-4 (IL-4) on the basophilic differentiation of KU812 cells. When KU812 cells were cultured with 1 ng/ml IL-4, cellular histam...

journal_title：Biochemical and biophysical research communications

authors： Hara T,Yamada K,Tachibana H

更新日期：1998-06-29 00:00:00

abstract：:Estrogen is the primary sex hormone responsible for the development and modulation of the female reproductive system in all vertebrates including avian species. The actions of estrogen are mediated by the estrogen receptor, which could be modulated by the selective estrogen receptor modulator tamoxifen (TAM). In this ...

journal_title：Biochemical and biophysical research communications

authors： Mao Y,Wu X,An L,Li X,Li Z,Zhu G

更新日期：2018-02-19 00:00:00

abstract：:A p60K protein in human colon adenocarcinoma tumor cell lines was identified as a myristoylated pp60c-src by fluorography and radioimmunoprecipitation analysis. Prevention of the myristoylation of pp60c-src was determined with N-fatty acyl glycinal compounds. Of the compounds tested, N-myristoyl glycinal diethylacetal...

journal_title：Biochemical and biophysical research communications

authors： Shoji S,Kurosawa T,Inoue H,Funakoshi T,Kubota Y

更新日期：1990-12-31 00:00:00

abstract：:We show that an autocrine system for calcitonin gene-related peptide (CGRP) exists in F9 teratocarcinoma cells. Synthesis of CGRP by F9 cells was demonstrated by measuring the peptide concentration in cells and medium and by determining specific mRNA in cells. During six days of culture, CGRP secretion did not vary si...

journal_title：Biochemical and biophysical research communications

authors： Segond N,Gerbaud P,Cressent M,Lasmoles F,Taboulet J,Jullienne A,Raynaud F,Moukhtar MS,Evain-Brion D

更新日期：1992-08-31 00:00:00

abstract：:The phthalate ester insensitive blue-green algae (Synechococcus lividus) were used as a food source to extend the survival of synchronously hatched brine shrimp (Artemia salina) larvae allowing measurement of a reduced toxic response to phthalate esters at late post-hatching stages of development. The maximum acute to...

journal_title：Biochemical and biophysical research communications

authors： Acey RA,Bailey S,Healy P,Jo C,Unger TF,Hudson RA

更新日期：2002-12-13 00:00:00

abstract：:The effect of opioids on NO production by LPS-stimulated murine macrophages J774 has been investigated. Morphine (mu and k opioid receptor agonist), DAGO (selective mu receptor agonist) and U50-488H (selective k receptor agonist), added (10(-10)-10(-6) M) to the cells 0.5 h before activation with LPS, significantly in...

journal_title：Biochemical and biophysical research communications

authors： Iuvone T,Capasso A,D'Acquisto F,Carnuccio R

更新日期：1995-07-26 00:00:00

abstract：:MicroRNAs (miRNAs) are non-protein-coding RNAs that function as post-transcriptional gene regulators. Recent evidence has shown that miRNA plays a pivotal role in the development of many cancers including glioma, a lethal brain cancer. We have recently compared the miRNA expression profiles between normal brain and gl...

journal_title：Biochemical and biophysical research communications

authors： Xia H,Qi Y,Ng SS,Chen X,Chen S,Fang M,Li D,Zhao Y,Ge R,Li G,Chen Y,He ML,Kung HF,Lai L,Lin MC

更新日期：2009-03-06 00:00:00