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Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.

Abstract：

:A novel human GPCR gene was cloned by PCR with degenerate primers designed from cannabinoid type 1 receptor (CB1) sequences and a full-length clone was isolated by screening of a human genomic DNA library. This gene, termed EDG-3, is highly homologous (51.9 % overall and 69.2 % in seven transmembrane regions) to human EDG-1, 47.9 % to rat AGR16 but only 28.0 % to human CB1 receptor. The Northern hybridization analysis showed that a 2.8 kb transcript of EDG-3 is abundantly expressed in the heart followed by placenta, kidney and liver. The EDG-3 gene was mapped on the human chromosome 9q22.1-q22.2 by fluorescence in situ hybridization analysis. Although the ligand and physiological role of this receptor is unknown, this gene may be a new member of the EDG family.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Yamaguchi F,Tokuda M,Hatase O,Brenner S

doi

10.1006/bbrc.1996.1553

subject

Has Abstract

pub_date

1996-10-14 00:00:00

pages

608-14

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(96)91553-3

journal_volume

227

pub_type

杂志文章

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