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MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells.

Abstract：

:MicroRNAs (miRNAs) are non-protein-coding RNAs that function as post-transcriptional gene regulators. Recent evidence has shown that miRNA plays a pivotal role in the development of many cancers including glioma, a lethal brain cancer. We have recently compared the miRNA expression profiles between normal brain and glioma tissues from Chinese patients by miRNA microarray and identified a panel of differentially expressed miRNAs. Here, we studied the function of one miRNA, miR-15b, in glioma carcinogenesis and elucidated its downstream targets. Over-expression of miR-15b resulted in cell cycle arrest at G0/G1 phase while suppression of miR-15b expression resulted in a decrease of cell populations in G0/G1 and a corresponding increase of cell populations in S phase. We further showed that CCNE1 (encoding cyclin E1) is one of the downstream targets of miR-15b. Taken together, our findings indicate that miR-15b regulates cell cycle progression in glioma cells by targeting cell cycle-related molecules.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Xia H,Qi Y,Ng SS,Chen X,Chen S,Fang M,Li D,Zhao Y,Ge R,Li G,Chen Y,He ML,Kung HF,Lai L,Lin MC

doi

10.1016/j.bbrc.2008.12.169

subject

Has Abstract

pub_date

2009-03-06 00:00:00

pages

205-10

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(08)02572-2

journal_volume

380

pub_type

杂志文章

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