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Insulin suppression of VLDL apo B secretion is not mediated by the LDL receptor.

Abstract：

:Insulin inhibits hepatic very low density lipoprotein (VLDL) apo B secretion in rats. Current studies test whether the insulin effect is LDL receptor-mediated by examining the effect of insulin on VLDL apo B secretion in hepatocytes derived from Ldlr-/- and control mice. Primary hepatocytes were incubated overnight with media containing 14C-leucine and either 0.1nM (basal) or 200nM insulin. Afterwards, secreted VLDL B100 and B48 were quantitated. Insulin reduced 14C-labeled B100 and B48 comparably in control and Ldlr-/- hepatocytes with a 62+/-12% vs. 59+/-12% decrease in B100, and a 56+/-11% vs. 61+/-9% decrease in B48. Results indicate: (1) mouse hepatocytes respond to insulin by reducing VLDL apo B output; (2) both VLDL B100 and B48 secretion are suppressed; and (3) insulin inhibition of VLDL apo B secretion is retained in Ldlr-/- hepatocytes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Chirieac DV,Cianci J,Collins HL,Sparks JD,Sparks CE

doi

10.1016/s0006-291x(02)02140-x

subject

Has Abstract

pub_date

2002-09-13 00:00:00

pages

134-7

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006291X0202140X

journal_volume

297

pub_type

杂志文章

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