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Evidence for specific binding of 15 hydroxyeicosatetraenoic acid to pituitary rat cells.

Abstract：

:Specific receptors for [3H]-15 HETE have been identified on GH3 cells, a cloned strain of rat pituitary cells. With incremental inputs of radioligand and a constant cell number, specific [3H]-15 HETE binding reached a plateau indicative of saturable binding sites. Ligand analysis of the Scatchard plot demonstrated a single class of high affinity binding sites with a dissociation constant (Kd) of 0.75 nM. 12 HETE competed with radiolabeled 15 HETE (IC50 = 1 x 10(-6) +/- 0.8 M). In contrast, arachidonic acid, leukotriene B4, prostaglandins E2 and F2 alpha did not compete with [3H]-15 HETE.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Rabier M,Crastes de Paulet A,Damon M

doi

10.1016/s0006-291x(88)80409-1

subject

Has Abstract

pub_date

1988-05-16 00:00:00

pages

1179-84

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(88)80409-1

journal_volume

152

pub_type

杂志文章

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